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Structure paper

TitleStructural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Journal, issue, pagesBiochem. J., Vol. 375, Page 255-, Year 2003
Publish dateAug 1, 2003 (structure data deposition date)
AuthorsKomander, D. / Kular, G.S. / Bain, J. / Elliot, M. / Alessi, D.R. / Van Aalten, D.M.F.
External linksBiochem. J. / PubMed:12892559
MethodsX-ray diffraction
Resolution2.3 - 2.51 Å
Structure data

PDB-1oky:
Structure of human PDK1 kinase domain in complex with staurosporine
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1okz:
Structure of human PDK1 kinase domain in complex with UCN-01
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-UCN:
7-HYDROXYSTAUROSPORINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / PKB / PDK1 / STAUROSPORINE / UCN-01 / 7-HYDROXY STAUROSPORINE / INHIBITOR / ATP-BINDING / PHOSPHORYLATION

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