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TitleFormamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism
Journal, issue, pagesJ. Biol. Chem., Vol. 278, Page 36699-36706, Year 2003
Publish dateApr 13, 2003 (structure data deposition date)
AuthorsVenkataramaiah, T.H. / Plapp, B.V.
External linksJ. Biol. Chem. / PubMed:12855684
MethodsX-ray diffraction
Resolution1.57 Å
Structure data

PDB-1p1r:
Horse liver alcohol dehydrogenase complexed with NADH and R-N-1-methylhexylformamide
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NAI:
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE

ChemComp-NMH:
(R)-N-(1-METHYL-HEXYL)-FORMAMIDE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • equus caballus (horse)
KeywordsOXIDOREDUCTASE / puckered reduced nicotinamide ring / Michaelis complex analogue / formamide

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