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Structure paper

TitleThe oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Journal, issue, pagesNat. Struct. Biol., Vol. 10, Page 527-534, Year 2003
Publish dateMar 12, 2003 (structure data deposition date)
AuthorsBell, J.K. / Goetz, D.H. / Mahrus, S. / Harris, J.L. / Fletterick, R.J. / Craik, C.S.
External linksNat. Struct. Biol. / PubMed:12819769
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1orf:
The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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