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Structure paper

TitleStructural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 100, Page 6440-, Year 2003
Publish dateMar 5, 2003 (structure data deposition date)
AuthorsPetitpas, I. / Petersen, C.E. / Ha, C.E. / Bhattacharya, A.A. / Zunszain, P.A. / Ghuman, J. / Bhagavan, N.V. / Curry, S.
External linksProc. Natl. Acad. Sci. USA / PubMed:12743361
MethodsX-ray diffraction
Resolution2.4 - 2.8 Å
Structure data

PDB-1hk1:
HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-1hk2:
HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1hk3:
Human serum albumin mutant r218p complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1hk4:
HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1hk5:
HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-T44:
3,5,3',5'-TETRAIODO-L-THYRONINE / hormone*YM

ChemComp-HOH:
WATER

ChemComp-MYR:
MYRISTIC ACID

Source
  • homo sapiens (human)
KeywordsPLASMA PROTEIN / HORMONE-BINDING / LIPID-BINDING / THYROXINE / FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA

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