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Structure paper

TitleStructure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab
Journal, issue, pagesNature, Vol. 421, Page 756-760, Year 2003
Publish dateNov 21, 2002 (structure data deposition date)
AuthorsCho, H.-S. / Mason, K. / Ramyar, K.X. / Stanley, A.M. / Gabelli, S.B. / Denney Jr., D.W. / Leahy, D.J.
External linksNature / PubMed:12610629
MethodsX-ray diffraction
Resolution2.4 - 2.52 Å
Structure data

PDB-1n8y:
Crystal structure of the extracellular region of rat HER2
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1n8z:
Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSFERASE / tyrosin kinase receptor / cell surface receptor

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