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Structure paper

TitleSubstrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation.
Journal, issue, pagesJ. Mol. Biol., Vol. 326, Page 1025-1035, Year 2003
Publish dateDec 2, 2002 (structure data deposition date)
AuthorsO'Farrell, D. / Trowbridge, R. / Rowlands, D. / Jager, J.
External linksJ. Mol. Biol. / PubMed:12589751
MethodsX-ray diffraction
Resolution2 - 2.9 Å
Structure data

PDB-1nb4:
HC-J4 RNA polymerase apo-form
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1nb6:
HC-J4 RNA polymerase complexed with UTP
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1nb7:
HC-J4 RNA polymerase complexed with short RNA template strand
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-UTP:
URIDINE 5'-TRIPHOSPHATE / UTP*YM

Source
  • hepatitis c virus
KeywordsTRANSFERASE / Hepatitis C Virus / replication / RNA polymerase / de-novo priming / function analysis / HCV / NS5B / RDRP / TRANSFERASE/RNA / TRANSFERASE-RNA COMPLEX

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