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Structure paper

TitleCrystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism
Journal, issue, pagesJ. Mol. Biol., Vol. 326, Page 517-527, Year 2003
Publish dateAug 8, 2002 (structure data deposition date)
AuthorsProsise, G.L. / Luecke, H.
External linksJ. Mol. Biol. / PubMed:12559919
MethodsX-ray diffraction
Resolution1.95 - 2.2 Å
Structure data

PDB-1me9:
Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP bound
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1meh:
Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-1mei:
Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1mew:
Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and NAD bound
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-IMP:
INOSINIC ACID

ChemComp-HOH:
WATER

ChemComp-MOA:
MYCOPHENOLIC ACID / medication, immunosuppressant*YM

ChemComp-XMP:
XANTHOSINE-5'-MONOPHOSPHATE

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

Source
  • tritrichomonas foetus (eukaryote)
KeywordsOXIDOREDUCTASE / alpha beta barrel

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