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Structure paper

TitleThe Immunosuppressive Agent Mizoribine Monophosphate Forms a Transition State Analogue Complex with Inosine Monophosphate Dehydrogenase
Journal, issue, pagesBiochemistry, Vol. 42, Page 857-863, Year 2003
Publish dateJun 27, 2003 (structure data deposition date)
AuthorsGan, L. / Seyedsayamdost, M. / Shuto, S. / Matsuda, A. / Petsko, G.A. / Hedstrom, L.
External linksBiochemistry / PubMed:12549902
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1pvn:
The crystal structure of the complex between IMP dehydrogenase catalytic domain and a transition state analogue MZP
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-MZP:
4-CARBAMOYL-1-BETA-D-RIBOFURANOSYL-IMIDAZOLIUM-5-OLATE-5'-PHOSPHATE

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • tritrichomonas foetus (eukaryote)
KeywordsOXIDOREDUCTASE / Transition state analogue / IMP dehydrogenase / Mizoribine 5'-monophosphate / distal flap / general base / drug selectivity

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