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Structure paper

TitleStructures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 112, Page 99-111, Year 2003
Publish dateAug 28, 2002 (structure data deposition date)
AuthorsShimaoka, M. / Xiao, T. / Liu, J.H. / Yang, Y.T. / Dong, Y.C. / Jun, C.D. / McCormack, A. / Zhang, R.G. / Joachimiak, A. / Takagi, J. ...Shimaoka, M. / Xiao, T. / Liu, J.H. / Yang, Y.T. / Dong, Y.C. / Jun, C.D. / McCormack, A. / Zhang, R.G. / Joachimiak, A. / Takagi, J. / Wang, J.H. / Springer, T.A.
External linksCell(Cambridge,Mass. ) / PubMed:12526797
MethodsX-ray diffraction
Resolution1.3 - 3.3 Å
Structure data

PDB-1mjn:
Crystal Structure of the intermediate affinity aL I domain mutant
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-1mq8:
Crystal structure of alphaL I domain in complex with ICAM-1
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-1mq9:
Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1mqa:
Crystal structure of high affinity alphaL I domain in the absence of ligand or metal
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Rossmann Fold / Ig superfamily / metal mediated protein interface / Designed disulfide bridge

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