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TitleStructures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 58, Page 1992-2000, Year 2002
Publish dateJul 22, 2002 (structure data deposition date)
AuthorsParthasarathy, S. / Balaram, H. / Balaram, P. / Murthy, M.R.
External linksActa Crystallogr. ,Sect. D / PubMed:12454456
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1m7o:
Plasmodium Falciparum Triosephosphate isomerase (PfTIM) compled to substrate analog 3-phosphoglycerate (3PG)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1m7p:
Plasmodium Falciparum Triosephosphate isomerase (PfTIM) compled to substrate analog glycerol-3-phosphate (G3P).
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-3PG:
3-PHOSPHOGLYCERIC ACID

ChemComp-HOH:
WATER

ChemComp-G3H:
GLYCERALDEHYDE-3-PHOSPHATE

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsISOMERASE / TIM barrels; beta-alpha barrels; enzyme-inhibitor complex / TIM barrles; beta-alpha barrels; enzyme-inhibitor complex

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