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Structure paper

TitleStructure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
Journal, issue, pagesJ. Biol. Chem., Vol. 278, Page 1802-1806, Year 2003
Publish dateAug 12, 2002 (structure data deposition date)
AuthorsElkins, J.M. / Hewitson, K.S. / McNeill, L.A. / Seibel, J.F. / Schlemminger, I. / Pugh, C. / Ratcliffe, P. / Schofield, C.J.
External linksJ. Biol. Chem. / PubMed:12446723
MethodsX-ray diffraction
Resolution2.15 - 2.84 Å
Structure data

PDB-1h2k:
Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-1h2l:
Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-1h2m:
Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1h2n:
Factor Inhibiting HIF-1 alpha
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION ACTIVATOR/INHIBITOR / TRANSCRIPTION ACTIVATOR-INHIBITOR COMPLEX / FIH / HIF / DSBH / OXYGENASE / TRANSCRIPTION / HYPOXIA / 2- OXOGLUTARATE / ASPARAGINYL HYDROXYLASE / PHOSPHORYLATION / TRANSCRIPTION ACTIVATOR INHIBITOR COMPLEX / HYDROXYLASE / OXIDOREDUCTASE / TRANSCRIPTION ACTIVATOR

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