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Structure paper

TitleThe mechanism of topoisomerase I poisoning by a camptothecin analog
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 99, Page 15387-15392, Year 2002
Publish dateOct 8, 2001 (structure data deposition date)
AuthorsStaker, B.L. / Hjerrild, K. / Feese, M.D. / Behnke, C.A. / Burgin Jr., A.B. / Stewart, L.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:12426403
MethodsX-ray diffraction
Resolution2.1 - 3.2 Å
Structure data

PDB-1k4s:
HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-1k4t:
HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-TTG:
2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID

ChemComp-TTC:
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE / medication, inhibitor*YM

ChemComp-HG:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/DNA / Complex (ISOMERASE-DNA) / DNA / Topoisomerase I / ISOMERASE-DNA complex / drug / poison

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