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TitleCrystal Structure of Uninhibited Factor VIIa Link its Cofactor and Substrate-assisted Activation to Specific Interactions
Journal, issue, pagesJ. Mol. Biol., Vol. 322, Page 591-603, Year 2002
Publish dateDec 12, 2001 (structure data deposition date)
AuthorsSichler, K. / Banner, D.W. / D'Arcy, A. / Hopfner, K.P. / Huber, R. / Bode, W. / Kresse, G.B. / Kopetzki, E. / Brandstetter, H.
External linksJ. Mol. Biol. / PubMed:12225752
MethodsX-ray diffraction
Resolution1.69 - 2.44 Å
Structure data

PDB-1kli:
Cofactor-and substrate-assisted activation of factor VIIa
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-1klj:
Crystal structure of uninhibited factor VIIa
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CA:
Unknown entry

ChemComp-BEN:
BENZAMIDINE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsHYDROLASE / extrinsic coagulation pathway / serine protease activation / rational drug design / substrate-assisted catalysis

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