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TitleZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES
Journal, issue, pagesJ. MOL. BIOL., Vol. 321, Page 591-599, Year 2002
Publish dateJun 12, 2002 (structure data deposition date)
AuthorsZhou, L. / Cheng, X. / Connolly, B.A. / Dickman, M.J. / Hurd, P.J. / Hornby, D.P.
External linksJ. MOL. BIOL. / PubMed:12206775
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1m0e:
ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

Source
  • haemophilus haemolyticus (bacteria)
KeywordsTRANSFERASE/DNA / Protein-DNA covalent complex / Mechanism based DNA methylation inhibitors / Zebularine / TRANSFERASE-DNA COMPLEX

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