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TitleAn RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Journal, issue, pagesEmbo J., Vol. 21, Page 2757-2768, Year 2002
Publish dateMar 25, 2002 (structure data deposition date)
AuthorsEgloff, M.P. / Benarroch, D. / Selisko, B. / Romette, J.L. / Canard, B.
External linksEmbo J. / PubMed:12032088
MethodsX-ray diffraction
Resolution2.4 - 2.9 Å
Structure data

PDB-1l9k:
dengue methyltransferase
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2p1d:
Crystal structure of dengue methyltransferase in complex with GTP and S-Adenosyl-L-homocysteine
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

Source
  • dengue virus
  • dengue virus 2
KeywordsTRANSFERASE / methyltransferase fold / complex with s-adenosyl-l-homocysteine / VIRAL PROTEIN / VIZIER; Viral Enzymes Involved in Replication; Dengue virus methyltransferase; Structural Genomics; Marseilles Structural Genomics Program @ AFMB; MSGP / VIZIER. Viral Enzymes Involved in Replication

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