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TitleThe Crystal Structure of the Zymogen Catalytic Domain of Complement Protease C1R Reveals that a Disruptive Mechanical Stress is Required to Trigger Activation of the C1 Complex.
Journal, issue, pagesEmbo J., Vol. 21, Page 231-, Year 2002
Publish dateNov 15, 2001 (structure data deposition date)
AuthorsBudayova-Spano, M. / Lacroix, M. / Thielens, N. / Arlaud, G. / Fontecilla-Camps, J.C. / Gaboriaud, C.
External linksEmbo J. / PubMed:11823416
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-1gpz:
THE CRYSTAL STRUCTURE OF THE ZYMOGEN CATALYTIC DOMAIN OF COMPLEMENT PROTEASE C1R
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ACTIVATION / COMPLEMENT / INNATE IMMUNITY / MODULAR STRUCTURE / SERINE PROTEASE

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