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TitleCrystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Journal, issue, pagesNat Struct Biol, Vol. 8, Issue 10, Page 838-842, Year 2001
Publish dateOct 18, 2001
AuthorsR S Williams / R Green / J N Glover /
PubMed AbstractThe C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human ...The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.
External linksNat Struct Biol / PubMed:11573086
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1jnx:
Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / BRCT / CANCER / GENE EXPRESSION

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