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TitleMechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.
Journal, issue, pagesBiochemistry, Vol. 40, Page 8227-8236, Year 2001
Publish dateMar 14, 2001 (structure data deposition date)
AuthorsKervinen, J. / Jaffe, E.K. / Stauffer, F. / Neier, R. / Wlodawer, A. / Zdanov, A.
External linksBiochemistry / PubMed:11444968
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1i8j:
CRYSTAL STRUCTURE OF PORPHOBILINOGEN SYNTHASE COMPLEXED WITH THE INHIBITOR 4,7-DIOXOSEBACIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-DSB:
4,7-DIOXOSEBACIC ACID

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsLYASE / HEME BIOSYNTHESIS / MAGNESIUM / 4 / 7-DIOXOSEBACIC ACID

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