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Structure paper

TitleInhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone.
Journal, issue, pagesBiochemistry, Vol. 40, Page 6233-6239, Year 2001
Publish dateNov 28, 2000 (structure data deposition date)
AuthorsCrichlow, G.V. / Nukaga, M. / Doppalapudi, V.R. / Buynak, J.D. / Knox, J.R.
External linksBiochemistry / PubMed:11371184
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-1ga0:
STRUCTURE OF THE E. CLOACAE GC1 BETA-LACTAMASE WITH A CEPHALOSPORIN SULFONE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-DVR:
3-(4-CARBAMOYL-1-CARBOXY-2-METHYLSULFONYL-BUTA-1,3-DIENYLAMINO)-INDOLIZINE-2-CARBOXYLIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • enterobacter cloacae (bacteria)
KeywordsHYDROLASE / mixed alpha/beta / cephalosporinase / inhibition / conformational change / class C beta-lactamase

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