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Structure paper

TitleDevelopment of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.
Journal, issue, pagesJ. Med. Chem., Vol. 43, Page 4948-4963, Year 2000
Publish dateOct 26, 2000 (structure data deposition date)
AuthorsNatchus, M.G. / Bookland, R.G. / De, B. / Almstead, N.G. / Pikul, S.
External linksJ. Med. Chem. / PubMed:11150165
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1g49:
A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-111:
(1N)-4-N-BUTOXYPHENYLSULFONYL-(2R)-N-HYDROXYCARBOXAMIDO-(4S)-METHANESULFONYLAMINO-PYRROLIDINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / mixed alpha beta structure / Zinc protease / inhibited

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