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TitleCrystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 103, Page 931-, Year 2000
Publish dateNov 20, 2000 (structure data deposition date)
AuthorsPacold, M.E. / Suire, S. / Perisic, O. / Lara-Gonzalez, S. / Davis, C.T. / Walker, E.H. / Hawkins, P.T. / Stephens, L. / Eccleston, J.F. / Williams, R.L.
External linksCell(Cambridge,Mass. ) / PubMed:11136978
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-1he8:
Ras G12V - PI 3-kinase gamma complex
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsKINASE/HYDROLASE / COMPLEX (PHOSPHOINOSITIDE KINASE-RAS) / PHOSPHOINOSITIDE 3-KINASE GAMMA - H-RAS G12V COMPLEX / PHOSPHATIDYLINOSITOL 3-KINASE / PI3K / PI 3-K / PI 3-KINASE / SECOND MESSENGER GENERATION / RAS EFFECTOR / H-RAS G12V / ONCOGENE PROTEIN / GMPPNP / GTP / RAS-BINDING DOMAIN / HEAT DOMAIN / KINASE-HYDROLASE complex

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