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Structure paper

TitleThe Crystal Structure of the Penicillin-Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance.
Journal, issue, pagesJ. Mol. Biol., Vol. 299, Page 477-, Year 2000
Publish dateSep 28, 1999 (structure data deposition date)
AuthorsGordon, E.J. / Mouz, N. / Duee, E. / Dideberg, O.
External linksJ. Mol. Biol. / PubMed:10860753
MethodsX-ray diffraction
Resolution2.4 - 2.8 Å
Structure data

PDB-1qme:
PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1qmf:
PENICILLIN-BINDING PROTEIN 2X (PBP-2X) ACYL-ENZYME COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CES:
2-[CARBOXY-(2-FURAN-2-YL-2-METHOXYIMINO-ACETYLAMINO)-METHYL]-5-METHYL-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID

ChemComp-KEF:
CEFUROXIME (OCT-3-ENE FORM)

Source
  • streptococcus pneumoniae (bacteria)
KeywordsPENICILLIN-BINDING PROTEIN / PEPTIDOGLYCAN SYNTHESIS / RESISTANCE / CELL WALL / TRANSMEMBRANE / CELL CYCLE

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