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TitleInactive Conformation of the Serpin Alpha1-Antichymotrypsin Indicates Two-Stage Insertion of the Reactive Loop: Implications for Inhibitory Function and Conformational Disease
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 97, Page 67-, Year 2000
Publish dateOct 4, 1999 (structure data deposition date)
AuthorsGooptu, B. / Hazes, B. / Chang, W.-S.W. / Dafforn, T.R. / Carrell, R.W. / Read, R.J. / Lomas, D.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:10618372
MethodsX-ray diffraction
Resolution2.27 Å
Structure data

PDB-1qmn:
Alpha1-antichymotrypsin serpin in the delta conformation (partial loop insertion)
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Source
  • homo sapiens (human)
KeywordsHYDROLASE INHIBITOR / SERPIN / SERINE PROTEINASE INHIBITOR / HYDROLASE INHIBITOR LOOP-SHEET POLYMERIZATION / EMPHYSEMA / DISEASE MUTATION / ACUTE PHASE PROTEIN / CONFORMATIONAL DISEASE

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