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Structure paper

TitleStructural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Journal, issue, pagesBiochemistry, Vol. 38, Page 12041-, Year 1999
Publish dateJun 18, 1999 (structure data deposition date)
AuthorsTang, L. / Whittingham, J.L. / Verma, C.S. / Caves, L.S.D. / Dodson, G.G.
External linksBiochemistry / PubMed:10508408
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-1qiy:
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1qiz:
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1qj0:
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-RCO:
RESORCINOL

Source
  • homo sapiens (human)
KeywordsHORMONE / GLUCOSE METABOLISM / DIABETES / INSULIN MUTANT

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