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TitleThe 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
Journal, issue, pagesBiochemistry, Vol. 38, Page 9872-9880, Year 1999
Publish dateApr 8, 1999 (structure data deposition date)
AuthorsShi, W. / Li, C.M. / Tyler, P.C. / Furneaux, R.H. / Cahill, S.M. / Girvin, M.E. / Grubmeyer, C. / Schramm, V.L. / Almo, S.C.
External linksBiochemistry / PubMed:10433693
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1cjb:
MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-IRP:
(1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE

ChemComp-POP:
PYROPHOSPHATE 2-

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsTRANSFERASE / MALARIA / PURINE SALVAGE / PHOSPHORIBOSYLTRANSFERASE / TRANSITION STATE INHIBITOR

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