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TitleStructure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Journal, issue, pagesStructure Fold. Des., Vol. 7, Page 297-307, Year 1999
Publish dateMar 4, 1998 (structure data deposition date)
AuthorsKryger, G. / Silman, I. / Sussman, J.L.
External linksStructure Fold. Des. / PubMed:10368299
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1eve:
THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-E20:
1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE

ChemComp-HOH:
WATER

Source
  • torpedo californica (Pacific electric ray)
KeywordsSERINE HYDROLASE / ALZHEIMER'S DISEASE / DRUG / ALPHA/BETA HYDROLASE / NEUROTRANSMITTER CLEAVAGE / CATALYTIC TRIAD / GLYCOSYLATED PROTEIN

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