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TitleStructural basis of BAX pore formation.
Journal, issue, pagesScience, Vol. 388, Issue 6754, Page eadv4314, Year 2025
Publish dateJun 26, 2025
AuthorsYing Zhang / Lu Tian / Gaoxingyu Huang / Xiaofei Ge / Fang Kong / Pengqi Wang / Yige Xu / Yigong Shi /
PubMed AbstractDuring apoptosis, cytosolic BAX monomers are translocated to the mitochondria to permeabilize the outer membrane. Here, we identified a dimer of BAX dimers as the basic repeating unit of its various ...During apoptosis, cytosolic BAX monomers are translocated to the mitochondria to permeabilize the outer membrane. Here, we identified a dimer of BAX dimers as the basic repeating unit of its various oligomeric forms: arcs, lines, and rings. Cryo-electron microscopy structure of the BAX repeating unit at 3.2-angstrom resolution revealed the interactions within and between dimers. End-to-end stacking of the repeating units through the protruding α9 pairs yielded lines, arcs, polygons, and rings. We structurally characterized the tetragon, pentagon, hexagon, and heptagon, which comprise 16, 20, 24, and 28 BAX protomers, respectively. Missense mutations at the BAX inter-protomer interface damage pore formation and cripple its proapoptotic function. The assembly principle of the various BAX oligomers reported here provides the structural basis of membrane permeabilization by BAX.
External linksScience / PubMed:40570108
MethodsEM (single particle)
Resolution3.19 - 18.1 Å
Structure data

60977

9ixu

EMDB-60977, PDB-9ixu:
Overall reconstruction of the Bax line
Method: EM (single particle) / Resolution: 3.19 Å

EMDB-61005: Tetragon ring reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 8.8 Å

EMDB-61007: Pentagon reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 9.6 Å

EMDB-61010: Hexagon reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 9.6 Å

EMDB-61017: Heptagonal reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 18.1 Å

EMDB-61020: tetragon vertex reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 5.12 Å

EMDB-61021: Pentagon vertex reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 5.02 Å

EMDB-61022: Hexagon vertex reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 5.27 Å

EMDB-61023: Heptagon vertex reconstruction of the BAX ring
Method: EM (single particle) / Resolution: 5.53 Å

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / Pore forming Bax proteins

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