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| Title | Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. |
|---|---|
| Journal, issue, pages | Cell, Vol. 184, Issue 19, Page 4969-4980.e15, Year 2021 |
| Publish date | Sep 16, 2021 |
 Authors | Pei Tong / Avneesh Gautam / Ian W Windsor / Meghan Travers / Yuezhou Chen / Nicholas Garcia / Noah B Whiteman / Lindsay G A McKay / Nadia Storm / Lauren E Malsick / Anna N Honko / Felipe J N Lelis / Shaghayegh Habibi / Simon Jenni / Yongfei Cai / Linda J Rennick / W Paul Duprex / Kevin R McCarthy / Christy L Lavine / Teng Zuo / Junrui Lin / Adam Zuiani / Jared Feldman / Elizabeth A MacDonald / Blake M Hauser / Anthony Griffths / Michael S Seaman / Aaron G Schmidt / Bing Chen / Donna Neuberg / Goran Bajic / Stephen C Harrison / Duane R Wesemann /  |
| PubMed Abstract | Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to antigenically drifted variants. We charted memory B ...Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found seven major antibody competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of antibody-S complexes identified corresponding epitopic regions. Group assignment correlated with cross-CoV-reactivity breadth, neutralization potency, and convergent antibody signatures. Although emerging SARS-CoV-2 variants of concern escaped binding by many members of the groups associated with the most potent neutralizing activity, some antibodies in each of those groups retained affinity-suggesting that otherwise redundant components of a primary immune response are important for durable protection from evolving pathogens. Our results furnish a global atlas of S-specific memory B cell repertoires and illustrate properties driving viral escape and conferring robustness against emerging variants. |
 External links | Cell / PubMed:34332650 / PubMed Central |
| Methods | EM (single particle) |
| Resolution | 11.7 Å |
| Structure data |  EMDB-24194: |
| Source |
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Severe acute respiratory syndrome coronavirus 2
