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TitleRemdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
Journal, issue, pagesMol Cell, Vol. 81, Issue 7, Page 1548-11552.e4, Year 2021
Publish dateApr 1, 2021
AuthorsJack P K Bravo / Tyler L Dangerfield / David W Taylor / Kenneth A Johnson /
PubMed AbstractRemdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase ...Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of 3 copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporation of 3 bases following RMP, resulting in delayed chain termination, which can guide the rational design of improved antiviral drugs.
External linksMol Cell / PubMed:33631104 / PubMed Central
MethodsEM (single particle)
Resolution3.89 Å
Structure data

23109

7l1f

EMDB-23109, PDB-7l1f:
SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate
Method: EM (single particle) / Resolution: 3.89 Å

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/RNA / VIRAL PROTEIN / VIRAL PROTEIN-RNA complex

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