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TitleDeciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methods
Journal, issue, pagesTo Be Published
Publish dateOct 2, 2024 (structure data deposition date)
AuthorsCastel J / Botzanowski T / Brooks I / Frechard A / Bey G / Schroeter M / Del nero E / Debaene F / Ciesielski F / Zeyer D ...Castel J / Botzanowski T / Brooks I / Frechard A / Bey G / Schroeter M / Del nero E / Debaene F / Ciesielski F / Zeyer D / Cianferani S / Morales R
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.5 Å
Structure data

51700

9gyo

EMDB-51700, PDB-9gyo:
CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395
Method: EM (single particle) / Resolution: 2.5 Å

Chemicals

ChemComp-FWX:
2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide

ChemComp-CLR:
CHOLESTEROL

Source
  • homo sapiens (human)
  • lama glama (llama)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / G-protein coupled receptor / transmembrane protein / G protein signaling / bile acid-binding.

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