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TitleSynthetic alpha-synuclein fibrils replicate in mice causing MSA neuropathology
Journal, issue, pagesTo Be Published, Year 2024
Publish dateJul 15, 2025 (structure data deposition date)
AuthorsBurger D / Kashyrina M / van den Heuvel L / de La Seigliere H / Lewis AJ / De Nuccio F / Mohammed I / Verchere J / Feuillie C / Berbon M ...Burger D / Kashyrina M / van den Heuvel L / de La Seigliere H / Lewis AJ / De Nuccio F / Mohammed I / Verchere J / Feuillie C / Berbon M / Arotcarena M / Retailleau A / Bezard E / Canron M / Meissner WG / Loquet A / Bousset L / Poujol C / Nilsson KPR / Laferriere F / Baron T / Lofrumento DD / De Giorgi F / Stahlberg H / Ichas F
External linksTo Be Published / Search PubMed
MethodsEM (helical sym.)
Resolution3.8 Å
Structure data

54402

9rzf

EMDB-54402, PDB-9rzf:
Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils
Method: EM (helical sym.) / Resolution: 3.8 Å

Source
  • mus musculus (house mouse)
KeywordsPROTEIN FIBRIL / Alpha-synuclein / Prion-like / Fibril / Paired helical filament

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