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-Structure paper
Title | Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. |
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Journal, issue, pages | Chemmedchem, Page e202400273-e202400273, Year 2024 |
Publish date | Jul 21, 2024 (structure data deposition date) |
Authors | You, W. / Montoya, A.L. / Dana, S. / Franzini, R.M. / Steegborn, C. |
External links | Chemmedchem / PubMed:38940296 |
Methods | X-ray diffraction |
Resolution | 1.75 Å |
Structure data | PDB-9g7h: |
Chemicals | ChemComp-AR6: ChemComp-ZN: PDB-1iiz: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | GENE REGULATION / Deacylase / inhibitor / DNA-Encoded Chemical Libraries / Acyl binding pocket / Aging |