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- EMDB-14321: Human nuclear pore complex (dilated) -

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基本情報

登録情報
データベース: EMDB / ID: EMD-14321
タイトルHuman nuclear pore complex (dilated)
マップデータStructure of the human nuclear pore complex from HEK cells
試料
  • 細胞器官・細胞要素: Human nuclear pore complex from HEK cells
    • タンパク質・ペプチド: x 25種
キーワードnucleocytoplasmic transport / multiprotein complex / TRANSPORT PROTEIN
機能・相同性
機能・相同性情報


cytoplasmic side of nuclear pore / nuclear pore transmembrane ring / GATOR2 complex / nephron development / centriole assembly / positive regulation of centriole replication / cytoplasmic periphery of the nuclear pore complex / regulation of protein import into nucleus / Seh1-associated complex / regulation of Ras protein signal transduction ...cytoplasmic side of nuclear pore / nuclear pore transmembrane ring / GATOR2 complex / nephron development / centriole assembly / positive regulation of centriole replication / cytoplasmic periphery of the nuclear pore complex / regulation of protein import into nucleus / Seh1-associated complex / regulation of Ras protein signal transduction / HuR (ELAVL1) binds and stabilizes mRNA / positive regulation of mitotic cytokinetic process / SUMO ligase complex / SUMO ligase activity / protein exit from endoplasmic reticulum / COPII-coated vesicle budding / protein localization to nuclear inner membrane / nuclear pore inner ring / annulate lamellae / nuclear envelope organization / nuclear pore localization / regulation of nucleocytoplasmic transport / nuclear pore central transport channel / transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery / COPII-coated vesicle cargo loading / nuclear pore outer ring / nuclear pore complex assembly / telomere tethering at nuclear periphery / atrial cardiac muscle cell action potential / nuclear pore organization / homologous chromosome pairing at meiosis / somite development / COPII vesicle coat / positive regulation of protein localization to centrosome / nuclear pore cytoplasmic filaments / post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery / nuclear export signal receptor activity / paraxial mesoderm development / Nuclear Pore Complex (NPC) Disassembly / nuclear inclusion body / nuclear pore nuclear basket / Amino acids regulate mTORC1 / Transport of Ribonucleoproteins into the Host Nucleus / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / miRNA processing / attachment of mitotic spindle microtubules to kinetochore / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / NS1 Mediated Effects on Host Pathways / SUMOylation of SUMOylation proteins / negative regulation of Ras protein signal transduction / protein-containing complex localization / microtubule bundle formation / Transport of Mature mRNA Derived from an Intronless Transcript / structural constituent of nuclear pore / nuclear localization sequence binding / positive regulation of mRNA splicing, via spliceosome / Rev-mediated nuclear export of HIV RNA / 転移酵素; アシル基を移すもの; アミノアシル基を移すもの / Nuclear import of Rev protein / Flemming body / SUMOylation of RNA binding proteins / nuclear export / fertilization / NLS-bearing protein import into nucleus / mitotic centrosome separation / NEP/NS2 Interacts with the Cellular Export Machinery / Transport of Mature mRNA derived from an Intron-Containing Transcript / RNA export from nucleus / centrosome cycle / tRNA processing in the nucleus / Postmitotic nuclear pore complex (NPC) reformation / SUMO transferase activity / negative regulation of programmed cell death / COPII-mediated vesicle transport / nucleocytoplasmic transport / neural tube development / lamellipodium assembly / centrosome localization / positive regulation of epidermal growth factor receptor signaling pathway / Viral Messenger RNA Synthesis / poly(A)+ mRNA export from nucleus / PTB domain binding / regulation of gluconeogenesis / mitotic metaphase chromosome alignment / SUMOylation of ubiquitinylation proteins / female gonad development / Vpr-mediated nuclear import of PICs / negative regulation of epidermal growth factor receptor signaling pathway / macrophage chemotaxis / SUMOylation of DNA replication proteins / protein sumoylation / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; セリンエンドペプチターゼ / positive regulation of SMAD protein signal transduction / ribosomal large subunit export from nucleus / RHOA GTPase cycle / positive regulation of TOR signaling / mitotic spindle assembly / mRNA transport
類似検索 - 分子機能
: / NUP210 Ig-like domain / Nucleoporin protein Ndc1-Nup / Nuclear pore membrane glycoprotein 210-like / : / : / : / : / : / Nucleoporin protein Ndc1-Nup ...: / NUP210 Ig-like domain / Nucleoporin protein Ndc1-Nup / Nuclear pore membrane glycoprotein 210-like / : / : / : / : / : / Nucleoporin protein Ndc1-Nup / NUP210 Ig-like domain 15 / NUP210 Ig-like domain 7 / NUP210 Ig-like domain 3 / NUP210 Ig-like domain 1 / NUP210 Ig-like domain 2 / Nucleoporin, NUP53 / Aladin / Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain / Nucleoporin Nup214 phenylalanine-glycine (FG) domain / ELYS-like domain / ELYS, beta-propeller domain / : / Nuclear pore complex assembly / beta-propeller of ELYS nucleoporin / Nucleoporin Nup88 / Nuclear pore component / Nup188 SH3-like domain / RNA-recognition motif (RRM) Nup35-type domain / Nup53/35/40-type RNA recognition motif / Nucleoporin FG repeated region / RNA-recognition motif (RRM) Nup35-type domain profile. / Nucleoporin NUP88/NUP82 / Nup54, C-terminal interacting domain / Nup54 C-terminal interacting domain / Nucleoporin Nup120/160, beta-propeller domain / Nucleoporin Nup188, N-terminal / Nucleoporin Nup188, N-terminal / Nucleoporin p58/p45 / Nucleoporin Nup37 / Nucleoporin Nup188 / : / Nucleoporin Nup188, N-terminal subdomain III / Nucleoporin, Nup155-like, C-terminal, subdomain 3 / Nucleoporin Nup54/Nup57/Nup44 / Nucleoporin Nup54, alpha-helical domain / Nucleoporin complex subunit 54 / Nucleoporin, NSP1-like, C-terminal / Nucleoporin NSP1/NUP62 / Nsp1-like C-terminal region / Nucleoporin Nup85-like / Nucleoporin Nup120/160 / Nup85 Nucleoporin / Nup98, Gle2-binding sequence / Nuclear pore protein 84/107 / Nuclear pore protein 84 / 107 / Nuclear pore complex protein Nup133-like / Nucleoporin, Nup155-like, C-terminal, subdomain 1 / Nucleoporin, Nup155-like, C-terminal, subdomain 2 / Nucleoporin, Nup155-like / Nuclear pore complex protein / Nucleoporin Nup186/Nup192/Nup205 / Nuclear pore complex scaffold, nucleoporins 186/192/205 / Nucleoporin, Nup133/Nup155-like, C-terminal / Nup358/RanBP2 E3 ligase domain / Non-repetitive/WGA-negative nucleoporin C-terminal / Nup358/RanBP2 E3 ligase domain / Nucleoporin interacting component Nup93/Nic96 / Nup93/Nic96 / Nucleoporin, Nup133/Nup155-like, N-terminal / Nup133 N terminal like / Sec13/Seh1 family / Nuclear pore complex protein NUP96, C-terminal domain / Nuclear protein 96 / Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain / Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily / Nucleoporin peptidase S59-like / Nup98-96 autopeptidase S59 / NUP C-terminal domain profile. / Bacterial Ig-like domain (group 2) / Ran binding protein RanBP1-like / Bacterial Ig-like domain 2 / Invasin/intimin cell-adhesion fragments / Ran binding domain / RanBP1 domain / Ran binding domain type 1 profile. / Ran-binding domain / Bacterial Ig-like domain, group 2 / Zinc finger domain / Zn-finger in Ran binding protein and others / Zinc finger RanBP2 type profile. / Zinc finger, RanBP2-type superfamily / Zinc finger RanBP2-type signature. / Zinc finger, RanBP2-type / Quinoprotein alcohol dehydrogenase-like superfamily / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily
類似検索 - ドメイン・相同性
Nuclear pore complex protein Nup155 / Nuclear pore complex protein Nup214 / Nuclear pore glycoprotein p62 / E3 SUMO-protein ligase RanBP2 / Nuclear pore complex protein Nup98-Nup96 / Protein SEC13 homolog / Nuclear pore complex protein Nup107 / Nuclear pore complex protein Nup160 / Nucleoporin NUP188 / Nucleoporin p54 ...Nuclear pore complex protein Nup155 / Nuclear pore complex protein Nup214 / Nuclear pore glycoprotein p62 / E3 SUMO-protein ligase RanBP2 / Nuclear pore complex protein Nup98-Nup96 / Protein SEC13 homolog / Nuclear pore complex protein Nup107 / Nuclear pore complex protein Nup160 / Nucleoporin NUP188 / Nucleoporin p54 / Nuclear pore complex protein Nup93 / Nucleoporin Nup43 / Nucleoporin Nup37 / Nucleoporin NUP35 / Nuclear pore membrane glycoprotein 210 / Nuclear pore complex protein Nup133 / Protein ELYS / Nuclear pore complex protein Nup205 / Nucleoporin SEH1 / Nuclear pore complex protein Nup88 / Nucleoporin NDC1 / Nucleoporin p58/p45 / Nuclear pore complex protein Nup85 / Aladin
類似検索 - 構成要素
生物種Homo sapiens (ヒト)
手法サブトモグラム平均法 / クライオ電子顕微鏡法 / 解像度: 50.0 Å
データ登録者Mosalaganti S / Obarska-Kosinska A
資金援助European Union, ドイツ, 2件
OrganizationGrant number国
European Research Council (ERC)724349European Union
German Federal Ministry for Education and Research031L0100 ドイツ
引用ジャーナル: Science / 年: 2022
タイトル: AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
著者: Shyamal Mosalaganti / Agnieszka Obarska-Kosinska / Marc Siggel / Reiya Taniguchi / Beata Turoňová / Christian E Zimmerli / Katarzyna Buczak / Florian H Schmidt / Erica Margiotta / Marie- ...著者: Shyamal Mosalaganti / Agnieszka Obarska-Kosinska / Marc Siggel / Reiya Taniguchi / Beata Turoňová / Christian E Zimmerli / Katarzyna Buczak / Florian H Schmidt / Erica Margiotta / Marie-Therese Mackmull / Wim J H Hagen / Gerhard Hummer / Jan Kosinski / Martin Beck /
要旨: INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate ...INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ∼120 MDa, the human NPC is one of the larg-est protein complexes. Its ~1000 proteins are taken in multiple copies from a set of about 30 distinct nucleoporins (NUPs). They can be roughly categorized into two classes. Scaf-fold NUPs contain folded domains and form a cylindrical scaffold architecture around a central channel. Intrinsically disordered NUPs line the scaffold and extend into the central channel, where they interact with cargo complexes. The NPC architecture is highly dynamic. It responds to changes in nuclear envelope tension with conforma-tional breathing that manifests in dilation and constriction movements. Elucidating the scaffold architecture, ultimately at atomic resolution, will be important for gaining a more precise understanding of NPC function and dynamics but imposes a substantial chal-lenge for structural biologists. RATIONALE Considerable progress has been made toward this goal by a joint effort in the field. A synergistic combination of complementary approaches has turned out to be critical. In situ structural biology techniques were used to reveal the overall layout of the NPC scaffold that defines the spatial reference for molecular modeling. High-resolution structures of many NUPs were determined in vitro. Proteomic analysis and extensive biochemical work unraveled the interaction network of NUPs. Integra-tive modeling has been used to combine the different types of data, resulting in a rough outline of the NPC scaffold. Previous struc-tural models of the human NPC, however, were patchy and limited in accuracy owing to several challenges: (i) Many of the high-resolution structures of individual NUPs have been solved from distantly related species and, consequently, do not comprehensively cover their human counterparts. (ii) The scaf-fold is interconnected by a set of intrinsically disordered linker NUPs that are not straight-forwardly accessible to common structural biology techniques. (iii) The NPC scaffold intimately embraces the fused inner and outer nuclear membranes in a distinctive topol-ogy and cannot be studied in isolation. (iv) The conformational dynamics of scaffold NUPs limits the resolution achievable in structure determination. RESULTS In this study, we used artificial intelligence (AI)-based prediction to generate an exten-sive repertoire of structural models of human NUPs and their subcomplexes. The resulting models cover various domains and interfaces that so far remained structurally uncharac-terized. Benchmarking against previous and unpublished x-ray and cryo-electron micros-copy structures revealed unprecedented accu-racy. We obtained well-resolved cryo-electron tomographic maps of both the constricted and dilated conformational states of the hu-man NPC. Using integrative modeling, we fit-ted the structural models of individual NUPs into the cryo-electron microscopy maps. We explicitly included several linker NUPs and traced their trajectory through the NPC scaf-fold. We elucidated in great detail how mem-brane-associated and transmembrane NUPs are distributed across the fusion topology of both nuclear membranes. The resulting architectural model increases the structural coverage of the human NPC scaffold by about twofold. We extensively validated our model against both earlier and new experimental data. The completeness of our model has enabled microsecond-long coarse-grained molecular dynamics simulations of the NPC scaffold within an explicit membrane en-vironment and solvent. These simulations reveal that the NPC scaffold prevents the constriction of the otherwise stable double-membrane fusion pore to small diameters in the absence of membrane tension. CONCLUSION Our 70-MDa atomically re-solved model covers >90% of the human NPC scaffold. It captures conforma-tional changes that occur during dilation and constriction. It also reveals the precise anchoring sites for intrinsically disordered NUPs, the identification of which is a prerequisite for a complete and dy-namic model of the NPC. Our study exempli-fies how AI-based structure prediction may accelerate the elucidation of subcellular ar-chitecture at atomic resolution. [Figure: see text].
履歴
登録2022年2月10日-
ヘッダ(付随情報) 公開2022年9月21日-
マップ公開2022年9月21日-
更新2024年7月17日-
現状2024年7月17日処理サイト: PDBe / 状態: 公開

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構造の表示

添付画像

emd_14321.png

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マップ

ファイルダウンロード / ファイル: emd_14321.map.gz / 形式: CCP4 / 大きさ: 11.4 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈Structure of the human nuclear pore complex from HEK cells
投影像・断面図

画像のコントロール

大きさ
明度
コントラスト
その他
軸Z (Sec.)Y (Row.)X (Col.)
13.8 Å/pix.
x 144 pix.
= 1987.2 Å		13.8 Å/pix.
x 144 pix.
= 1987.2 Å		13.8 Å/pix.
x 144 pix.
= 1987.2 Å

表面

投影像

断面 (1/3)

断面 (1/2)

断面 (2/3)

画像は Spider により作成

ボクセルのサイズX=Y=Z: 13.8 Å
密度

ヒストグラム

ヒストグラム (対数)
表面レベル登録者による: 0.0891
最小 - 最大-0.76800793 - 0.87791944
平均 (標準偏差)0.003724998 (±0.06342158)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ144144144
Spacing144144144
セルA=B=C: 1987.2001 Å
α=β=γ: 90.0 °

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添付データ

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試料の構成要素

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全体 : Human nuclear pore complex from HEK cells

全体名称: Human nuclear pore complex from HEK cells
要素
  • 細胞器官・細胞要素: Human nuclear pore complex from HEK cells
    • タンパク質・ペプチド: E3 SUMO-protein ligase RanBP2
    • タンパク質・ペプチド: Nuclear pore membrane glycoprotein 210
    • タンパク質・ペプチド: Aladin
    • タンパク質・ペプチド: Nuclear pore complex protein Nup93
    • タンパク質・ペプチド: Nucleoporin NUP188 homolog
    • タンパク質・ペプチド: Nuclear pore complex protein Nup205
    • タンパク質・ペプチド: Nuclear pore complex protein Nup155
    • タンパク質・ペプチド: Nucleoporin NDC1
    • タンパク質・ペプチド: Nucleoporin NUP35
    • タンパク質・ペプチド: Nucleoporin p54
    • タンパク質・ペプチド: Nucleoporin p58/p45
    • タンパク質・ペプチド: Nuclear pore glycoprotein p62
    • タンパク質・ペプチド: Nuclear pore complex protein Nup133
    • タンパク質・ペプチド: Nuclear pore complex protein Nup107
    • タンパク質・ペプチド: Nuclear pore complex protein Nup96
    • タンパク質・ペプチド: Protein SEC13 homolog
    • タンパク質・ペプチド: Nucleoporin SEH1
    • タンパク質・ペプチド: Nuclear pore complex protein Nup85
    • タンパク質・ペプチド: Nucleoporin Nup43
    • タンパク質・ペプチド: Nuclear pore complex protein Nup160
    • タンパク質・ペプチド: Nucleoporin Nup37
    • タンパク質・ペプチド: Protein ELYS
    • タンパク質・ペプチド: Nuclear pore complex protein Nup98
    • タンパク質・ペプチド: Nuclear pore complex protein Nup214
    • タンパク質・ペプチド: Nuclear pore complex protein Nup88

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超分子 #1: Human nuclear pore complex from HEK cells

超分子名称: Human nuclear pore complex from HEK cells / タイプ: organelle_or_cellular_component / ID: 1 / 親要素: 0 / 含まれる分子: all
由来(天然)生物種: Homo sapiens (ヒト)

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分子 #1: E3 SUMO-protein ligase RanBP2

分子名称: E3 SUMO-protein ligase RanBP2 / タイプ: protein_or_peptide / ID: 1 / コピー数: 5 / 光学異性体: LEVO
EC番号: 転移酵素; アシル基を移すもの; アミノアシル基を移すもの
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 358.654375 KDa
配列文字列: MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP KAHRFLGLLY ELEENTDKAV ECYRRSVEL NPTQKDLVLK IAELLCKNDV TDGRAKYWLE RAAKLFPGSP AIYKLKEQLL DCEGEDGWNK LFDLIQSELY V RPDDVHVN ...文字列:
MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP KAHRFLGLLY ELEENTDKAV ECYRRSVEL NPTQKDLVLK IAELLCKNDV TDGRAKYWLE RAAKLFPGSP AIYKLKEQLL DCEGEDGWNK LFDLIQSELY V RPDDVHVN IRLVEVYRST KRLKDAVAHC HEAERNIALR SSLEWNSCVV QTLKEYLESL QCLESDKSDW RATNTDLLLA YA NLMLLTL STRDVQESRE LLQSFDSALQ SVKSLGGNDE LSATFLEMKG HFYMHAGSLL LKMGQHSSNV QWRALSELAA LCY LIAFQV PRPKIKLIKG EAGQNLLEMM ACDRLSQSGH MLLNLSRGKQ DFLKEIVETF ANKSGQSALY DALFSSQSPK DTSF LGSDD IGNIDVREPE LEDLTRYDVG AIRAHNGSLQ HLTWLGLQWN SLPALPGIRK WLKQLFHHLP HETSRLETNA PESIC ILDL EVFLLGVVYT SHLQLKEKCN SHHSSYQPLC LPLPVCKQLC TERQKSWWDA VCTLIHRKAV PGNVAKLRLL VQHEIN TLR AQEKHGLQPA LLVHWAECLQ KTGSGLNSFY DQREYIGRSV HYWKKVLPLL KIIKKKNSIP EPIDPLFKHF HSVDIQA SE IVEYEEDAHI TFAILDAVNG NIEDAVTAFE SIKSVVSYWN LALIFHRKAE DIENDALSPE EQEECKNYLR KTRDYLIK I IDDSDSNLSV VKKLPVPLES VKEMLNSVMQ ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS PTRYSLSPSK SYKYSPKTP PRWAEDQNSL LKMICQQVEA IKKEMQELKL NSSNSASPHR WPTENYGPDS VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLL RPAANVTPTK GPVYGMNRLP PQQHIYAYPQ QMHTPPVQSS SACMFSQEMY GPPALRFESP ATGILSPRGD D YFNYNVQQ TSTNPPLPEP GYFTKPPIAA HASRSAESKT IEFGKTNFVQ PMPGEGLRPS LPTQAHTTQP TPFKFNSNFK SN DGDFTFS SPQVVTQPPP AAYSNSESLL GLLTSDKPLQ GDGYSGAKPI PGGQTIGPRN TFNFGSKNVS GISFTENMGS SQQ KNSGFR RSDDMFTFHG PGKSVFGTPT LETANKNHET DGGSAHGDDD DDGPHFEPVV PLPDKIEVKT GEEDEEEFFC NRAK LFRFD VESKEWKERG IGNVKILRHK TSGKIRLLMR REQVLKICAN HYISPDMKLT PNAGSDRSFV WHALDYADEL PKPEQ LAIR FKTPEEAALF KCKFEEAQSI LKAPGTNVAM ASNQAVRIVK EPTSHDNKDI CKSDAGNLNF EFQVAKKEGS WWHCNS CSL KNASTAKKCV SCQNLNPSNK ELVGPPLAET VFTPKTSPEN VQDRFALVTP KKEGHWDCSI CLVRNEPTVS RCIACQN TK SANKSGSSFV HQASFKFGQG DLPKPINSDF RSVFSTKEGQ WDCSACLVQN EGSSTKCAAC QNPRKQSLPA TSIPTPAS F KFGTSETSKT LKSGFEDMFA KKEGQWDCSS CLVRNEANAT RCVACQNPDK PSPSTSVPAP ASFKFGTSET SKAPKSGFE GMFTKKEGQW DCSVCLVRNE ASATKCIACQ NPGKQNQTTS AVSTPASSET SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATKCIACQ NPGKQNQTTS AVSTPASSET SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATKCIACQC PSKQNQTTAI S TPASSEIS KAPKSGFEGM FIRKGQWDCS VCCVQNESSS LKCVACDASK PTHKPIAEAP SAFTLGSEMK LHDSSGSQVG TG FKSNFSE KASKFGNTEQ GFKFGHVDQE NSPSFMFQGS SNTEFKSTKE GFSIPVSADG FKFGISEPGN QEKKSEKPLE NGT GFQAQD ISGQKNGRGV IFGQTSSTFT FADLAKSTSG EGFQFGKKDP NFKGFSGAGE KLFSSQYGKM ANKANTSGDF EKDD DAYKT EDSDDIHFEP VVQMPEKVEL VTGEEDEKVL YSQRVKLFRF DAEVSQWKER GLGNLKILKN EVNGKLRMLM RREQV LKVC ANHWITTTMN LKPLSGSDRA WMWLASDFSD GDAKLEQLAA KFKTPELAEE FKQKFEECQR LLLDIPLQTP HKLVDT GRA AKLIQRAEEM KSGLKDFKTF LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA LDDSVSS SS VHASPLASSP VRKNLFRFGE STTGFNFSFK SALSPSKSPA KLNQSGTSVG TDEESDVTQE EERDGQYFEP VVPLPDLV E VSSGEENEQV VFSHRAKLYR YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV MRRDQVLKLC ANHRITPDMT LQNMKGTER VWLWTACDFA DGERKVEHLA VRFKLQDVAD SFKKIFDEAK TAQEKDSLIT PHVSRSSTPR ESPCGKIAVA VLEETTRERT DVIQGDDVA DATSEVEVSS TSETTPKAVV SPPKFVFGSE SVKSIFSSEK SKPFAFGNSS ATGSLFGFSF NAPLKSNNSE T SSVAQSGS ESKVEPKKCE LSKNSDIEQS SDSKVKNLFA SFPTEESSIN YTFKTPEKAK EKKKPEDSPS DDDVLIVYEL TP TAEQKAL ATKLKLPPTF FCYKNRPDYV SEEEEDDEDF ETAVKKLNGK LYLDGSEKCR PLEENTADNE KECIIVWEKK PTV EEKAKA DTLKLPPTFF CGVCSDTDED NGNGEDFQSE LQKVQEAQKS QTEEITSTTD SVYTGGTEVM VPSFCKSEEP DSIT KSISS PSVSSETMDK PVDLSTRKEI DTDSTSQGES KIVSFGFGSS TGLSFADLAS SNSGDFAFGS KDKNFQWANT GAAVF GTQS VGTQSAGKVG EDEDGSDEEV VHNEDIHFEP IVSLPEVEVK SGEEDEEILF KERAKLYRWD RDVSQWKERG VGDIKI LWH TMKNYYRILM RRDQVFKVCA NHVITKTMEL KPLNVSNNAL VWTASDYADG EAKVEQLAVR FKTKEVADCF KKTFEEC QQ NLMKLQKGHV SLAAELSKET NPVVFFDVCA DGEPLGRITM ELFSNIVPRT AENFRALCTG EKGFGFKNSI FHRVIPDF V CQGGDITKHD GTGGQSIYGD KFEDENFDVK HTGPGLLSMA NQGQNTNNSQ FVITLKKAEH LDFKHVVFGF VKDGMDTVK KIESFGSPKG SVCRRITITE CGQI

UniProtKB: E3 SUMO-protein ligase RanBP2

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分子 #2: Nuclear pore membrane glycoprotein 210

分子名称: Nuclear pore membrane glycoprotein 210 / タイプ: protein_or_peptide / ID: 2 / コピー数: 8 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 205.314406 KDa
配列文字列: MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQP ARLTSIIFAE DITTGQVLRC DAIVDLIHDI QIVSTTRELY LEDSPLELKI QALDSEGNTF STLAGLVFEW T IVKDSEAD ...文字列:
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQP ARLTSIIFAE DITTGQVLRC DAIVDLIHDI QIVSTTRELY LEDSPLELKI QALDSEGNTF STLAGLVFEW T IVKDSEAD RFSDSHNALR ILTFLESTYI PPSYISEMEK AAKQGDTILV SGMKTGSSKL KARIQEAVYK NVRPAEVRLL IL ENILLNP AYDVYLMVGT SIHYKVQKIR QGKITELSMP SDQYELQLQN SIPGPEGDPA RPVAVLAQDT SMVTALQLGQ SSL VLGHRS IRMQGASRLP NSTIYVVEPG YLGFTVHPGD RWVLETGRLY EITIEVFDKF SNKVYVSDNI RIETVLPAEF FEVL SSSQN GSYHRIRALK RGQTAIDAAL TSVVDQDGGV HILQVPVWNQ QEVEIHIPIT LYPSILTFPW QPKTGAYQYT IRAHG GSGN FSWSSSSHLV ATVTVKGVMT TGSDIGFSVI QAHDVQNPLH FGEMKVYVIE PHSMEFAPCQ VEARVGQALE LPLRIS GLM PGGASEVVTL SDCSHFDLAV EVENQGVFQP LPGRLPPGSE HCSGIRVKAE AQGSTTLLVS YRHGHVHLSA KITIAAY LP LKAVDPSSVA LVTLGSSKEM LFEGGPRPWI LEPSKFFQNV TAEDTDSIGL ALFAPHSSRN YQQHWILVTC QALGEQVI A LSVGNKPSLT NPFPAVEPAV VKFVCAPPSR LTLAPVYTSP QLDMSCPLLQ QNKQVVPVSS HRNPRLDLAA YDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIEL ILVEDVRVSP EEVTIYNHPG IQAELRIREG SGYFFLNTST ADVVKVAYQE ARGVAMVHPL LPGSSTIMIH D LCLVFPAP AKAVVYVSDI QELYIRVVDK VEIGKTVKAY VRVLDLHKKP FLAKYFPFMD LKLRAASPII TLVALDEALD NY TITFLIR GVAIGQTSLT ASVTNKAGQR INSAPQQIEV FPPFRLMPRK VTLLIGATMQ VTSEGGPQPQ SNILFSISNE SVA LVSAAG LVQGLAIGNG TVSGLVQAVD AETGKVVIIS QDLVQVEVLL LRAVRIRAPI MRMRTGTQMP IYVTGITNHQ NPFS FGNAV PGLTFHWSVT KRDVLDLRGR HHEASIRLPS QYNFAMNVLG RVKGRTGLRV VVKAVDPTSG QLYGLARELS DEIQV QVFE KLQLLNPEIE AEQILMSPNS YIKLQTNRDG AASLSYRVLD GPEKVPVVHV DEKGFLASGS MIGTSTIEVI AQEPFG ANQ TIIVAVKVSP VSYLRVSMSP VLHTQNKEAL VAVPLGMTVT FTVHFHDNSG DVFHAHSSVL NFATNRDDFV QIGKGPT NN TCVVRTVSVG LTLLRVWDAE HPGLSDFMPL PVLQAISPEL SGAMVVGDVL CLATVLTSLE GLSGTWSSSA NSILHIDP K TGVAVARAVG SVTVYYEVAG HLRTYKEVVV SVPQRIMARH LHPIQTSFQE ATASKVIVAV GDRSSNLRGE CTPTQREVI QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSP GLFADQAEIL LSNHYTSSEI RVFGAPEVLE NLEVKSGSPA VLAFAKEKSF GWPSFITYTV GVLDPAAGSQ G PLSTTLTF SSPVTNQAIA IPVTVAFVVD RRGPGPYGAS LFQHFLDSYQ VMFFTLFALL AGTAVMIIAY HTVCTPRDLA VP AALTPRA SPGHSPHYFA ASSPTSPNAL PPARKASPPS GLWSPAYASH

UniProtKB: Nuclear pore membrane glycoprotein 210

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分子 #3: Aladin

分子名称: Aladin / タイプ: protein_or_peptide / ID: 3 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 59.635918 KDa
配列文字列: MCSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR LDHGTRTAFI HHREQVWKRC INIWRDVGL FGVLNEIANS EEEVFEWVKT ASGWALALCR WASSLHGSLF PHLSLRSEDL IAEFAQVTNW SSCCLRVFAW H PHTNKFAV ...文字列:
MCSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR LDHGTRTAFI HHREQVWKRC INIWRDVGL FGVLNEIANS EEEVFEWVKT ASGWALALCR WASSLHGSLF PHLSLRSEDL IAEFAQVTNW SSCCLRVFAW H PHTNKFAV ALLDDSVRVY NASSTIVPSL KHRLQRNVAS LAWKPLSASV LAVACQSCIL IWTLDPTSLS TRPSSGCAQV LS HPGHTPV TSLAWAPSGG RLLSASPVDA AIRVWDVSTE TCVPLPWFRG GGVTNLLWSP DGSKILATTP SAVFRVWEAQ MWT CERWPT LSGRCQTGCW SPDGSRLLFT VLGEPLIYSL SFPERCGEGK GCVGGAKSAT IVADLSETTI QTPDGEERLG GEAH SMVWD PSGERLAVLM KGKPRVQDGK PVILLFRTRN SPVFELLPCG IIQGEPGAQP QLITFHPSFN KGALLSVGWS TGRIA HIPL YFVNAQFPRF SPVLGRAQEP PAGGGGSIHD LPLFTETSPT SAPWDPLPGP PPVLPHSPHS HL

UniProtKB: Aladin

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分子 #4: Nuclear pore complex protein Nup93

分子名称: Nuclear pore complex protein Nup93 / タイプ: protein_or_peptide / ID: 4 / コピー数: 7 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 93.599102 KDa
配列文字列: MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEP LEPVKDTDIQ GFLKNEKDNA LLSAIEESRK RTFGMAEEYH RESMLVEWEQ VKQRILHTLL ASGEDALDFT Q ESEPSYIS ...文字列:
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEP LEPVKDTDIQ GFLKNEKDNA LLSAIEESRK RTFGMAEEYH RESMLVEWEQ VKQRILHTLL ASGEDALDFT Q ESEPSYIS DVGPPGRSSL DNIEMAYARQ IYIYNEKIVN GHLQPNLVDL CASVAELDDK SISDMWTMVK QMTDVLLTPA TD ALKNRSS VEVRMEFVRQ ALAYLEQSYK NYTLVTVFGN LHQAQLGGVP GTYQLVRSFL NIKLPAPLPG LQDGEVEGHP VWA LIYYCM RCGDLLAASQ VVNRAQHQLG EFKTWFQEYM NSKDRRLSPA TENKLRLHYR RALRNNTDPY KRAVYCIIGR CDVT DNQSE VADKTEDYLW LKLNQVCFDD DGTSSPQDRL TLSQFQKQLL EDYGESHFTV NQQPFLYFQV LFLTAQFEAA VAFLF RMER LRCHAVHVAL VLFELKLLLK SSGQSAQLLS HEPGDPPCLR RLNFVRLLML YTRKFESTDP REALQYFYFL RDEKDS QGE NMFLRCVSEL VIESREFDMI LGKLENDGSR KPGVIDKFTS DTKPIINKVA SVAENKGLFE EAAKLYDLAK NADKVLE LM NKLLSPVVPQ ISAPQSNKER LKNMALSIAE RYRAQGISAN KFVDSTFYLL LDLITFFDEY HSGHIDRAFD IIERLKLV P LNQESVEERV AAFRNFSDEI RHNLSEVLLA TMNILFTQFK RLKGTSPSSS SRPQRVIEDR DSQLRSQART LITFAGMIP YRTSGDTNAR LVQMEVLMN

UniProtKB: Nuclear pore complex protein Nup93

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分子 #5: Nucleoporin NUP188 homolog

分子名称: Nucleoporin NUP188 homolog / タイプ: protein_or_peptide / ID: 5 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 196.256688 KDa
配列文字列: MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQS VQLLQCYLQE DYRGTRDSVK TVLQDERQSQ ALILKIADYY YEERTCILRC VLHLLTYFQD ERHPYRVEYA D CVDKLEKE ...文字列:
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQS VQLLQCYLQE DYRGTRDSVK TVLQDERQSQ ALILKIADYY YEERTCILRC VLHLLTYFQD ERHPYRVEYA D CVDKLEKE LVSKYRQQFE ELYKTEAPTW ETHGNLMTER QVSRWFVQCL REQSMLLEII FLYYAYFEMA PSDLLVLTKM FK EQGFGSR QTNRHLVDET MDPFVDRIGY FSALILVEGM DIESLHKCAL DDRRELHQFA QDGLICQDMD CLMLTFGDIP HHA PVLLAW ALLRHTLNPE ETSSVVRKIG GTAIQLNVFQ YLTRLLQSLA SGGNDCTTST ACMCVYGLLS FVLTSLELHT LGNQ QDIID TACEVLADPS LPELFWGTEP TSGLGIILDS VCGMFPHLLS PLLQLLRALV SGKSTAKKVY SFLDKMSFYN ELYKH KPHD VISHEDGTLW RRQTPKLLYP LGGQTNLRIP QGTVGQVMLD DRAYLVRWEY SYSSWTLFTC EIEMLLHVVS TADVIQ HCQ RVKPIIDLVH KVISTDLSIA DCLLPITSRI YMLLQRLTTV ISPPVDVIAS CVNCLTVLAA RNPAKVWTDL RHTGFLP FV AHPVSSLSQM ISAEGMNAGG YGNLLMNSEQ PQGEYGVTIA FLRLITTLVK GQLGSTQSQG LVPCVMFVLK EMLPSYHK W RYNSHGVREQ IGCLILELIH AILNLCHETD LHSSHTPSLQ FLCICSLAYT EAGQTVINIM GIGVDTIDMV MAAQPRSDG AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LSQHGAHGNN LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYAC LGNDAAAIRD AFLTRLQSKI EDMRIKVMIL EFLTVAVETQ PGLIELFLNL EVKDGSDGSK EFSLGMWSCL H AVLELIDS QQQDRYWCPP LLHRAAIAFL HALWQDRRDS AMLVLRTKPK FWENLTSPLF GTLSPPSETS EPSILETCAL IM KIICLEI YYVVKGSLDQ SLKDTLKKFS IEKRFAYWSG YVKSLAVHVA ETEGSSCTSL LEYQMLVSAW RMLLIIATTH ADI MHLTDS VVRRQLFLDV LDGTKALLLV PASVNCLRLG SMKCTLLLIL LRQWKRELGS VDEILGPLTE ILEGVLQADQ QLME KTKAK VFSAFITVLQ MKEMKVSDIP QYSQLVLNVC ETLQEEVIAL FDQTRHSLAL GSATEDKDSM ETDDCSRSRH RDQRD GVCV LGLHLAKELC EVDEDGDSWL QVTRRLPILP TLLTTLEVSL RMKQNLHFTE ATLHLLLTLA RTQQGATAVA GAGITQ SIC LPLLSVYQLS TNGTAQTPSA SRKSLDAPSW PGVYRLSMSL MEQLLKTLRY NFLPEALDFV GVHQERTLQC LNAVRTV QS LACLEEADHT VGFILQLSNF MKEWHFHLPQ LMRDIQVNLG YLCQACTSLL HSRKMLQHYL QNKNGDGLPS AVAQRVQR P PSAASAAPSS SKQPAADTEA SEQQALHTVQ YGLLKILSKT LAALRHFTPD VCQILLDQSL DLAEYNFLFA LSFTTPTFD SEVAPSFGTL LATVNVALNM LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL LMFTMENCFY LLISQAMRYL RDPAVHPRDK QRMKQELSS ELSTLLSSLS RYFRRGAPSS PATGVLPSPQ GKSTSLSKAS PESQEPLIQL VQAFVRHMQR

UniProtKB: Nucleoporin NUP188

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分子 #6: Nuclear pore complex protein Nup205

分子名称: Nuclear pore complex protein Nup205 / タイプ: protein_or_peptide / ID: 6 / コピー数: 5 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 228.172875 KDa
配列文字列: MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQ LIKEAFILSD LFDIGELAAV ELLLAGEHQQ PHFPGLTRGL VAVLLYWDGK RCIANSLKAL IQSRRGKTWT L ELSPELAS ...文字列:
MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQ LIKEAFILSD LFDIGELAAV ELLLAGEHQQ PHFPGLTRGL VAVLLYWDGK RCIANSLKAL IQSRRGKTWT L ELSPELAS MTTRFTDELM EQGLTYKVLT LVSQIDVNNE FEKLQRERGL GSEKHRKEVS DLIKECRQSL AESLFAWACQ SP LGKEDTL LLIGHLERVT VEANGSLDAV NLALLMALLY CFDISFIEQS TEERDDMIHQ LPLLTEKQYI ATIHSRLQDS QLW KLPGLQ ATVRLAWALA LRGISQLPDV TALAEFTEAD EAMAELAIAD NVFLFLMESV VVSEYFYQEE FYIRRVHNLI TDFL ALMPM KVKQLRNRAD EDARMIHMSM QMGNEPPISL RRDLEHLMLL IGELYKKNPF HLELALEYWC PTEPLQTPTI MGSYL GVAH QRPPQRQVVL SKFVRQMGDL LPPTIYIPYL KMLQGLANGP QCAHYCFSLL KVNGSSHVEN IQGAGGSPVS WEHFFH SLM LYHEHLRKDL PSADSVQYRH LPSRGITQKE QDGLIAFLQL TSTIITWSEN ARLALCEHPQ WTPVVVILGL LQCSIPP VL KAELLKTLAA FGKSPEIAAS LWQSLEYTQI LQTVRIPSQR QAIGIEVELN EIESRCEEYP LTRAFCQLIS TLVESSFP S NLGAGLRPPG FDPYLQFLRD SVFLRFRTRA YRRAAEKWEV AEVVLEVFYK LLRDYEPQLE DFVDQFVELQ GEEIIAYKP PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK HLEKAVQHCL ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPR TKKADNVVNI ARYLYHGNTN PELAFESAKI LCCISCNSNI QIKLVGDFTH DQSISQKLMA GFVECLDCED A EEFVRLEE GSELEKKLVA IRHETRIHIL NLLITSLECN PPNLALYLLG FELKKPVSTT NLQDPGVLGC PRTCLHAILN IL EKGTEGR TGPVAVRESP QLAELCYQVI YQLCACSDTS GPTMRYLRTS QDFLFSQLQY LPFSNKEYEI SMLNQMSWLM KTA SIELRV TSLNRQRSHT QRLLHLLLDD MPVKPYSDGE GGIEDENRSV SGFLHFDTAT KVRRKILNIL DSIDFSQEIP EPLQ LDFFD RAQIEQVIAN CEHKNLRGQT VCNVKLLHRV LVAEVNALQG MAAIGQRPLL MEEISTVLQY VVGRNKLLQC LHAKR HALE SWRQLVEIIL TACPQDLIQA EDRQLIIRDI LQDVHDKILD DEAAQELMPV VAGAVFTLTA HLSQAVLTEQ KETSVL GPA EAHYAFMLDS CFTSPPPEEN PLVGFASIGD SSLYIILKKL LDFILKTGGG FQRVRTHLYG SLLYYLQIAQ RPDEPDT LE AAKKTMWERL TAPEDVFSKL QRENIAIIES YGAALMEVVC RDACDGHEIG RMLALALLDR IVSVDKQQQW LLYLSNSG Y LKVLVDSLVE DDRTLQSLLT PQPPLLKALY TYESKMAFLT RVAKIQQGAL ELLRSGVIVR LAQCQVYDMR PETDPQSMF GMRDPPMFIP TPVDRYRQIL LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI SHSDTIQAIL RCQDVSAGSL QELALLTGII SKAALPGIL SELDVDVNEG SLMELQGHIG RFQRQCLGLL SRFGGSDRLR QFKFQDDNVE GDKVSKKDEI ELAMQQICAN V MEYCQSLM LQSSPTFQHA VCLFTPSLSE TVNRDGPRQD TQAPVVPYWR LPGLGIIIYL LKQSANDFFS YYDSHRQSVS KL QNVEQLP PDEIKELCQS VMPAGVDKIS TAQKYVLARR RLVKVINNRA KLLSLCSFII ETCLFILWRH LEYYLLHCMP TDS QDSLFA SRTLFKSRRL QDSFASETNL DFRSGLAIVS QHDLDQLQAD AINAFGESLQ KKLLDIEGLY SKVRSRYSFI QALV RRIRG LLRISRN

UniProtKB: Nuclear pore complex protein Nup205

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分子 #7: Nuclear pore complex protein Nup155

分子名称: Nuclear pore complex protein Nup155 / タイプ: protein_or_peptide / ID: 7 / コピー数: 6 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 155.357281 KDa
配列文字列: MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPL PPELVEQFGH MQCNCMMGVF PPISRAWLTI DSDIFMWNYE DGGDLAYFDG LSETILAVGL VKPKAGIFQP H VRHLLVLA ...文字列:
MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPL PPELVEQFGH MQCNCMMGVF PPISRAWLTI DSDIFMWNYE DGGDLAYFDG LSETILAVGL VKPKAGIFQP H VRHLLVLA TPVDIVILGL SYANLQTGSG VLNDSLSGGM QLLPDPLYSL PTDNTYLLTI TSTDNGRIFL AGKDGCLYEV AY QAEAGWF SQRCRKINHS KSSLSFLVPS LLQFTFSEDD PILQIAIDNS RNILYTRSEK GVIQVYDLGQ DGQGMSRVAS VSQ NAIVSA AGNIARTIDR SVFKPIVQIA VIENSESLDC QLLAVTHAGV RLYFSTCPFR QPLARPNTLT LVHVRLPPGF SASS TVEKP SKVHRALYSK GILLMAASEN EDNDILWCVN HDTFPFQKPM METQMTAGVD GHSWALSAID ELKVDKIITP LNKDH IPIT DSPVVVQQHM LPPKKFVLLS AQGSLMFHKL RPVDQLRHLL VSNVGGDGEE IERFFKLHQE DQACATCLIL ACSTAA CDR EVSAWATRAF FRYGGEAQMR FPTTLPPPSN VGPILGSPVY SSSPVPSGSP YPNPSFLGTP SHGIQPPAMS TPVCALG NP ATQATNMSCV TGPEIVYSGK HNGICIYFSR IMGNIWDASL VVERIFKSGN REITAIESSV PCQLLESVLQ ELKGLQEF L DRNSQFAGGP LGNPNTTAKV QQRLIGFMRP ENGNPQQMQQ ELQRKFHEAQ LSEKISLQAI QQLVRKSYQA LALWKLLCE HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS LINCYIRDNA AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQN KTEKERMLRE SLKEYQKISN QVDLSNVCAQ YRQVRFYEGV VELSLTAAEK KDPQGLGLHF YKHGEPEEDI V GLQAFQER LNSYKCITDT LQELVNQSKA APQSPSVPKK PGPPVLSSDP NMLSNEEAGH HFEQMLKLSQ RSKDELFSIA LY NWLIQVD LADKLLQVAS PFLEPHLVRM AKVDQNRVRY MDLLWRYYEK NRSFSNAARV LSRLADMHST EISLQQRLEY IAR AILSAK SSTAISSIAA DGEFLHELEE KMEVARIQLQ IQETLQRQYS HHSSVQDAVS QLDSELMDIT KLYGEFADPF KLAE CKLAI IHCAGYSDPI LVQTLWQDII EKELSDSVTL SSSDRMHALS LKIVLLGKIY AGTPRFFPLD FIVQFLEQQV CTLNW DVGF VIQTMNEIGV PLPRLLEVYD QLFKSRDPFW NRMKKPLHLL DCIHVLLIRY VENPSQVLNC ERRRFTNLCL DAVCGY LVE LQSMSSSVAV QAITGNFKSL QAKLERLH

UniProtKB: Nuclear pore complex protein Nup155

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分子 #8: Nucleoporin NDC1

分子名称: Nucleoporin NDC1 / タイプ: protein_or_peptide / ID: 8 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 76.377445 KDa
配列文字列: MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD SFSDLYSSYV IFYFLLLSVV IIIISIFNV EFYAVVPSIP CSRLALIGKI IHPQQLMHSF IHAAMGMVMA WCAAVITQGQ YSFLVVPCTG TNSFGSPAAQ T CLNEYHLF ...文字列:
MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD SFSDLYSSYV IFYFLLLSVV IIIISIFNV EFYAVVPSIP CSRLALIGKI IHPQQLMHSF IHAAMGMVMA WCAAVITQGQ YSFLVVPCTG TNSFGSPAAQ T CLNEYHLF FLLTGAFMGY SYSLLYFVNN MNYLPFPIIQ QYKFLRFRRS LLLLVKHSCV ESLFLVRNFC ILYYFLGYIP KA WISTAMN LHIDEQVHRP LDTVSGLLNL SLLYHVWLCG VFLLTTWYVS WILFKIYATE AHVFPVQPPF AEGSDECLPK VLN SNPPPI IKYLALQDLM LLSQYSPSRR QEVFSLSQPG GHPHNWTAIS RECLNLLNGM TQKLILYQEA AATNGRVSSS YPVE PKKLN SPEETAFQTP KSSQMPRPSV PPLVKTSLFS SKLSTPDVVS PFGTPFGSSV MNRMAGIFDV NTCYGSPQSP QLIRR GPRL WTSASDQQMT EFSNPSPSTS ISAEGKTMRQ PSVIYSWIQN KREQIKNFLS KRVLIMYFFS KHPEASIQAV FSDAQM HIW ALEGLSHLVA ASFTEDRFGV VQTTLPAILN TLLTLQEAVD KYFKLPHASS KPPRISGSLV DTSYKTLRFA FRASLKT AI YRITTTFGEH LNAVQASAEH QKRLQQFLEF KE

UniProtKB: Nucleoporin NDC1

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分子 #9: Nucleoporin NUP35

分子名称: Nucleoporin NUP35 / タイプ: protein_or_peptide / ID: 9 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 34.805664 KDa
配列文字列: MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAP PVRSIYDDIS SPGLGSTPLT SRRQPNISVM QSPLVGVTST PGTGQSMFSP ASIGQPRKTT LSPAQLDPFY T QGDSLTSE ...文字列:
MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAP PVRSIYDDIS SPGLGSTPLT SRRQPNISVM QSPLVGVTST PGTGQSMFSP ASIGQPRKTT LSPAQLDPFY T QGDSLTSE DHLDDSWVTV FGFPQASASY ILLQFAQYGN ILKHVMSNTG NWMHIRYQSK LQARKALSKD GRIFGESIMI GV KPCIDKS VMESSDRCAL SSPSLAFTPP IKTLGTPTQP GSTPRISTMR PLATAYKAST SDYQVISDRQ TPKKDESLVS KAM EYMFGW

UniProtKB: Nucleoporin NUP35

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分子 #10: Nucleoporin p54

分子名称: Nucleoporin p54 / タイプ: protein_or_peptide / ID: 10 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 55.491156 KDa
配列文字列: MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGG FNTQQQQQTT LGGLFSQPTQ APTQSNQLIN TASALSAPTL LGDERDAILA KWNQLQAFWG TGKGYFNNNI P PVEFTQEN ...文字列:
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGG FNTQQQQQTT LGGLFSQPTQ APTQSNQLIN TASALSAPTL LGDERDAILA KWNQLQAFWG TGKGYFNNNI P PVEFTQEN PFCRFKAVGY SCMPSNKDED GLVVLVFNKK ETEIRSQQQQ LVESLHKVLG GNQTLTVNVE GTKTLPDDQT EV VIYVVER SPNGTSRRVP ATTLYAHFEQ ANIKTQLQQL GVTLSMTRTE LSPAQIKQLL QNPPAGVDPI IWEQAKVDNP DSE KLIPVP MVGFKELLRR LKVQDQMTKQ HQTRLDIISE DISELQKNQT TSVAKIAQYK RKLMDLSHRT LQVLIKQEIQ RKSG YAIQA DEEQLRVQLD TIQGELNAPT QFKGRLNELM SQIRMQNHFG AVRSEERYYI DADLLREIKQ HLKQQQEGLS HLISI IKDD LEDIKLVEHG LNETIHIRGG VFS

UniProtKB: Nucleoporin p54

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分子 #11: Nucleoporin p58/p45

分子名称: Nucleoporin p58/p45 / タイプ: protein_or_peptide / ID: 11 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 60.94148 KDa
配列文字列: MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTI TTGLTLGTPA TTSAATTGFS LGFNKPAASA TPFALPITST SASGLTLSSA LTSTPAASTG FTLNNLGGTT A TTTTASTG ...文字列:
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTI TTGLTLGTPA TTSAATTGFS LGFNKPAASA TPFALPITST SASGLTLSSA LTSTPAASTG FTLNNLGGTT A TTTTASTG LSLGGALAGL GGSLFQSTNT GTSGLGQNAL GLTLGTTAAT STAGNEGLGG IDFSSSSDKK SDKTGTRPED SK ALKDENL PPVICQDVEN LQKFVKEQKQ VQEEISRMSS KAMLKVQEDI KALKQLLSLA ANGIQRNTLN IDKLKIETAQ ELK NAEIAL RTQKTPPGLQ HEYAAPADYF RILVQQFEVQ LQQYRQQIEE LENHLATQAN NSHITPQDLS MAMQKIYQTF VALA AQLQS IHENVKVLKE QYLGYRKMFL GDAVDVFETR RAEAKKWQNT PRVTTGPTPF STMPNAAAVA MAATLTQQQQ PATGP QPSL GVSFGTPFGS GIGTGLQSSG LGSSNLGGFG TSSGFGCSTT GASTFGFGTT NKPSGSLSAG FGSSSTSGFN FSNPGI TAS AGLTFGVSNP ASAGFGTGGQ LLQLKKPPAG NKRGKR

UniProtKB: Nucleoporin p58/p45

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分子 #12: Nuclear pore glycoprotein p62

分子名称: Nuclear pore glycoprotein p62 / タイプ: protein_or_peptide / ID: 12 / コピー数: 5 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 53.289574 KDa
配列文字列: MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFS LGIGASKLNL SNTAATPAMA NPSGFGLGSS NLTNAISSTV TSSQGTAPTG FVFGPSTTSV APATTSGGFS F TGGSTAQP ...文字列:
MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFS LGIGASKLNL SNTAATPAMA NPSGFGLGSS NLTNAISSTV TSSQGTAPTG FVFGPSTTSV APATTSGGFS F TGGSTAQP SGFNIGSAGN SAQPTAPATL PFTPATPAAT TAGATQPAAP TPTATITSTG PSLFASIATA PTSSATTGLS LC TPVTTAG APTAGTQGFS LKAPGAASGT STTTSTAATA TATTTSSSST TGFALNLKPL APAGIPSNTA AAVTAPPGPG AAA GAAASS AMTYAQLESL INKWSLELED QERHFLQQAT QVNAWDRTLI ENGEKITSLH REVEKVKLDQ KRLDQELDFI LSQQ KELED LLSPLEELVK EQSGTIYLQH ADEEREKTYK LAENIDAQLK RMAQDLKDII EHLNTSGAPA DTSDPLQQIC KILNA HMDS LQWIDQNSAL LQRKVEEVTK VCEGRRKEQE RSFRITFD

UniProtKB: Nuclear pore glycoprotein p62

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分子 #13: Nuclear pore complex protein Nup133

分子名称: Nuclear pore complex protein Nup133 / タイプ: protein_or_peptide / ID: 13 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 129.108461 KDa
配列文字列: MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLP VKVMEALTLA EVDDQLTINI DEGGWACLVC KEKLIIWKIA LSPITKLSVC KELQLPPSDF HWSADLVALS Y SSPSGEAH ...文字列:
MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLP VKVMEALTLA EVDDQLTINI DEGGWACLVC KEKLIIWKIA LSPITKLSVC KELQLPPSDF HWSADLVALS Y SSPSGEAH STQAVAVMVA TREGSIRYWP SLAGEDTYTE AFVDSGGDKT YSFLTAVQGG SFILSSSGSQ LIRLIPESSG KI HQHILPQ GQGMLSGIGR KVSSLFGILS PSSDLTLSSV LWDRERSSFY SLTSSNISKW ELDDSSEKHA YSWDINRALK ENI TDAIWG SESNYEAIKE GVNIRYLDLK QNCDGLVILA AAWHSADNPC LIYYSLITIE DNGCQMSDAV TVEVTQYNPP FQSE DLILC QLTVPNFSNQ TAYLYNESAV YVCSTGTGKF SLPQEKIVFN AQGDSVLGAG ACGGVPIIFS RNSGLVSITS RENVS ILAE DLEGSLASSV AGPNSESMIF ETTTKNETIA QEDKIKLLKA AFLQYCRKDL GHAQMVVDEL FSSHSDLDSD SELDRA VTQ ISVDLMDDYP ASDPRWAESV PEEAPGFSNT SLIILHQLED KMKAHSFLMD FIHQVGLFGR LGSFPVRGTP MATRLLL CE HAEKLSAAIV LKNHHSRLSD LVNTAILIAL NKREYEIPSN LTPADVFFRE VSQVDTICEC LLEHEEQVLR DAPMDSIE W AEVVINVNNI LKDMLQAASH YRQNRNSLYR REESLEKEPE YVPWTATSGP GGIRTVIIRQ HEIVLKVAYP QADSNLRNI VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL QKRSDLLSPL LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYM TQFADQNFSD FLFRWYLEKG KRGKLLSQPI SQHGQLANFL QAHEHLSWLH EINSQELEKA HATLLGLANM E TRYFAKKK TLLGLSKLAA LASDFSEDML QEKIEEMAEQ ERFLLHQETL PEQLLAEKQL NLSAMPVLTA PQLIGLYICE EN RRANEYD FKKALDLLEY IDEEEDININ DLKLEILCKA LQRDNWSSSD GKDDPIEVSK DSIFVKILQK LLKDGIQLSE YLP EVKDLL QADQLGSLKS NPYFEFVLKA NYEYYVQGQI

UniProtKB: Nuclear pore complex protein Nup133

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分子 #14: Nuclear pore complex protein Nup107

分子名称: Nuclear pore complex protein Nup107 / タイプ: protein_or_peptide / ID: 14 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 106.504969 KDa
配列文字列: MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR QPFTPTSRSL LRQPDISCIL GTGGKSPRL TQSSGFFGNL SMVTNLDDSN WAAAFSSQRS GLFTNTEPHS ITEDVTISAV MLREDDPGEA ASMSMFSDFL Q SFLKHSSS ...文字列:
MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR QPFTPTSRSL LRQPDISCIL GTGGKSPRL TQSSGFFGNL SMVTNLDDSN WAAAFSSQRS GLFTNTEPHS ITEDVTISAV MLREDDPGEA ASMSMFSDFL Q SFLKHSSS TVFDLVEEYE NICGSQVNIL SKIVSRATPG LQKFSKTASM LWLLQQEMVT WRLLASLYRD RIQSALEEES VF AVTAVNA SEKTVVEALF QRDSLVRQSQ LVVDWLESIA KDEIGEFSDN IEFYAKSVYW ENTLHTLKQR QLTSYVGSVR PLV TELDPD APIRQKMPLD DLDREDEVRL LKYLFTLIRA GMTEEAQRLC KRCGQAWRAA TLEGWKLYHD PNVNGGTELE PVEG NPYRR IWKISCWRMA EDELFNRYER AIYAALSGNL KQLLPVCDTW EDTVWAYFRV MVDSLVEQEI QTSVATLDET EELPR EYLG ANWTLEKVFE ELQATDKKRV LEENQEHYHI VQKFLILGDI DGLMDEFSKW LSKSRNNLPG HLLRFMTHLI LFFRTL GLQ TKEEVSIEVL KTYIQLLIRE KHTNLIAFYT CHLPQDLAVA QYALFLESVT EFEQRHHCLE LAKEADLDVA TITKTVV EN IRKKDNGEFS HHDLAPALDT GTTEEDRLKI DVIDWLVFDP AQRAEALKQG NAIMRKFLAS KKHEAAKEVF VKIPQDSI A EIYNQCEEQG MESPLPAEDD NAIREHLCIR AYLEAHETFN EWFKHMNSVP QKPALIPQPT FTEKVAHEHK EKKYEMDFG IWKGHLDALT ADVKEKMYNV LLFVDGGWMV DVREDAKEDH ERTHQMVLLR KLCLPMLCFL LHTILHSTGQ YQECLQLADM VSSERHKLY LVFSKEELRK LLQKLRESSL MLLDQGLDPL GYEIQL

UniProtKB: Nuclear pore complex protein Nup107

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分子 #15: Nuclear pore complex protein Nup96

分子名称: Nuclear pore complex protein Nup96 / タイプ: protein_or_peptide / ID: 15 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 106.039656 KDa
配列文字列: SKYGLQDSDE EEEEHPSKTS TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD TMLEESMPE DQEPVSASTH IASSLGINPH VLQIMKASLL TDEEDVDMAL DQRFSRLPSK ADTSQEICSP RLPISASHSS K TRSLVGGL ...文字列:
SKYGLQDSDE EEEEHPSKTS TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD TMLEESMPE DQEPVSASTH IASSLGINPH VLQIMKASLL TDEEDVDMAL DQRFSRLPSK ADTSQEICSP RLPISASHSS K TRSLVGGL LQSKFTSGAF LSPSVSVQEC RTPRAASLMN IPSTSSWSVP PPLTSVFTMP SPAPEVPLKT VGTRRQLGLV PR EKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEK LSLRQR KPDEDMKLYQ TPLELKLKHS TVHVDELCPL IVPNLGVAVI HDYADWVKEA SGDLPEAQIV KHWSLTWTLC EALW GHLKE LDSQLNEPRE YIQILERRRA FSRWLSCTAT PQIEEEVSLT QKNSPVEAVF SYLTGKRISE ACSLAQQSGD HRLAL LLSQ FVGSQSVREL LTMQLVDWHQ LQADSFIQDE RLRIFALLAG KPVWQLSEKK QINVCSQLDW KRSLAIHLWY LLPPTA SIS RALSMYEEAF QNTSDSDRYA CSPLPSYLEG SGCVIAEEQN SQTPLRDVCF HLLKLYSDRH YDLNQLLEPR SITADPL DY RLSWHLWEVL RALNYTHLSA QCEGVLQASY AGQLESEGLW EWAIFVLLHI DNSGIREKAV RELLTRHCQL LETPESWA K ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII RHLASDAIIN ENYDYLKGFL EDLAPPERS SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD RLAQSDMAKR VANLLRVVLS LHHPPDRTS DSTPDPQRVP LRLLAPHIGR LPMPEDYAMD ELRSLTQSYL RELAVGSL

UniProtKB: Nuclear pore complex protein Nup98-Nup96

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分子 #16: Protein SEC13 homolog

分子名称: Protein SEC13 homolog / タイプ: protein_or_peptide / ID: 16 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 35.578438 KDa
配列文字列: MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREE NGTWEKSHEH AGHDSSVNSV CWAPHDYGLI LACGSSDGAI SLLTYTGEGQ WEVKKINNAH TIGCNAVSWA P AVVPGSLI ...文字列:
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREE NGTWEKSHEH AGHDSSVNSV CWAPHDYGLI LACGSSDGAI SLLTYTGEGQ WEVKKINNAH TIGCNAVSWA P AVVPGSLI DHPSGQKPNY IKRFASGGCD NLIKLWKEEE DGQWKEEQKL EAHSDWVRDV AWAPSIGLPT STIASCSQDG RV FIWTCDD ASSNTWSPKL LHKFNDVVWH VSWSITANIL AVSGGDNKVT LWKESVDGQW VCISDVNKGQ GSVSASVTEG QQN EQ

UniProtKB: Protein SEC13 homolog

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分子 #17: Nucleoporin SEH1

分子名称: Nucleoporin SEH1 / タイプ: protein_or_peptide / ID: 17 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 39.700566 KDa
配列文字列: MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV WRVTWAHPEF GQVLASCSFD RTAAVWEEI VGESNDKLRG QSHWVKRTTL VDSRTSVTDV KFAPKHMGLM LATCSADGIV RIYEAPDVMN LSQWSLQHEI S CKLSCSCI ...文字列:
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV WRVTWAHPEF GQVLASCSFD RTAAVWEEI VGESNDKLRG QSHWVKRTTL VDSRTSVTDV KFAPKHMGLM LATCSADGIV RIYEAPDVMN LSQWSLQHEI S CKLSCSCI SWNPSSSRAH SPMIAVGSDD SSPNAMAKVQ IFEYNENTRK YAKAETLMTV TDPVHDIAFA PNLGRSFHIL AI ATKDVRI FTLKPVRKEL TSSGGPTKFE IHIVAQFDNH NSQVWRVSWN ITGTVLASSG DDGCVRLWKA NYMDNWKCTG ILK GNGSPV NGSSQQGTSN PSLGSTIPSL QNSLNGSSAG RKHS

UniProtKB: Nucleoporin SEH1

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分子 #18: Nuclear pore complex protein Nup85

分子名称: Nuclear pore complex protein Nup85 / タイプ: protein_or_peptide / ID: 18 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 75.105266 KDa
配列文字列: MEELDGEPTV TLIPGVNSKK NQMYFDWGPG EMLVCETSFN KKEKSEMVPS CPFIYIIRKD VDVYSQILRK LFNESHGIFL GLQRIDEEL TGKSRKSQLV RVSKNYRSVI RACMEEMHQV AIAAKDPANG RQFSSQVSIL SAMELIWNLC EILFIEVAPA G PLLLHLLD ...文字列:
MEELDGEPTV TLIPGVNSKK NQMYFDWGPG EMLVCETSFN KKEKSEMVPS CPFIYIIRKD VDVYSQILRK LFNESHGIFL GLQRIDEEL TGKSRKSQLV RVSKNYRSVI RACMEEMHQV AIAAKDPANG RQFSSQVSIL SAMELIWNLC EILFIEVAPA G PLLLHLLD WVRLHVCEVD SLSADVLGSE NPSKHDSFWN LVTILVLQGR LDEARQMLSK EADASPASAG ICRIMGDLMR TM PILSPGN TQTLTELELK WQHWHEECER YLQDSTFATS PHLESLLKIM LGDEAALLEQ KELLSNWYHF LVTRLLYSNP TVK PIDLHY YAQSSLDLFL GGESSPEPLD NILLAAFEFD IHQVIKECSI ALSNWWFVAH LTDLLDHCKL LQSHNLYFGS NMRE FLLLE YASGLFAHPS LWQLGVDYFD YCPELGRVSL ELHIERIPLN TEQKALKVLR ICEQRQMTEQ VRSICKILAM KAVRN NRLG SALSWSIRAK DAAFATLVSD RFLRDYCERG CFSDLDLIDN LGPAMMLSDR LTFLGKYREF HRMYGEKRFA DAASLL LSL MTSRIAPRSF WMTLLTDALP LLEQKQVIFS AEQTYELMRC LEDLTSRRPV HGESDTEQLQ DDDIETTKVE MLRLSLA RN LARAIIREGS LEGS

UniProtKB: Nuclear pore complex protein Nup85

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分子 #19: Nucleoporin Nup43

分子名称: Nucleoporin Nup43 / タイプ: protein_or_peptide / ID: 19 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 42.195652 KDa
配列文字列: MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIV AASSTGCVTV FLHHPNNQTL SVNQQWTTAH YHTGPGSPSY SSAPCTGVVC NNPEIVTVGE DGRINLFRAD H KEAVRTID ...文字列:
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIV AASSTGCVTV FLHHPNNQTL SVNQQWTTAH YHTGPGSPSY SSAPCTGVVC NNPEIVTVGE DGRINLFRAD H KEAVRTID NADSSTLHAV TFLRTPEILT VNSIGQLKIW DFRQQGNEPS QILSLTGDRV PLHCVDRHPN QQHVVATGGQ DG MLSIWDV RQGTMPVSLL KAHEAEMWEV HFHPSNPEHL FTCSEDGSLW HWDASTDVPE KSSLFHQGGR SSTFLSHSIS NQA NVHQSV ISSWLSTDPA KDRIEITSLL PSRSLSVNTL DVLGPCLVCG TDAEAIYVTR HLFS

UniProtKB: Nucleoporin Nup43

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分子 #20: Nuclear pore complex protein Nup160

分子名称: Nuclear pore complex protein Nup160 / タイプ: protein_or_peptide / ID: 20 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 162.280203 KDa
配列文字列: MLHLSAAPPA PPPEVTATAR PCLCSVGRRG DGGKMAAAGA LERSFVELSG AERERPRHFR EFTVCSIGTA NAVAGAVKYS ESAGGFYYV ESGKLFSVTR NRFIHWKTSG DTLELMEESL DINLLNNAIR LKFQNCSVLP GGVYVSETQN RVIILMLTNQ T VHRLLLPH ...文字列:
MLHLSAAPPA PPPEVTATAR PCLCSVGRRG DGGKMAAAGA LERSFVELSG AERERPRHFR EFTVCSIGTA NAVAGAVKYS ESAGGFYYV ESGKLFSVTR NRFIHWKTSG DTLELMEESL DINLLNNAIR LKFQNCSVLP GGVYVSETQN RVIILMLTNQ T VHRLLLPH PSRMYRSELV VDSQMQSIFT DIGKVDFTDP CNYQLIPAVP GISPNSTAST AWLSSDGEAL FALPCASGGI FV LKLPPYD IPGMVSVVEL KQSSVMQRLL TGWMPTAIRG DQSPSDRPLS LAVHCVEHDA FIFALCQDHK LRMWSYKEQM CLM VADMLE YVPVKKDLRL TAGTGHKLRL AYSPTMGLYL GIYMHAPKRG QFCIFQLVST ESNRYSLDHI SSLFTSQETL IDFA LTSTD IWALWHDAEN QTVVKYINFE HNVAGQWNPV FMQPLPEEEI VIRDDQDPRE MYLQSLFTPG QFTNEALCKA LQIFC RGTE RNLDLSWSEL KKEVTLAVEN ELQGSVTEYE FSQEEFRNLQ QEFWCKFYAC CLQYQEALSH PLALHLNPHT NMVCLL KKG YLSFLIPSSL VDHLYLLPYE NLLTEDETTI SDDVDIARDV ICLIKCLRLI EESVTVDMSV IMEMSCYNLQ SPEKAAE QI LEDMITIDVE NVMEDICSKL QEIRNPIHAI GLLIREMDYE TEVEMEKGFN PAQPLNIRMN LTQLYGSNTA GYIVCRGV H KIASTRFLIC RDLLILQQLL MRLGDAVIWG TGQLFQAQQD LLHRTAPLLL SYYLIKWGSE CLATDVPLDT LESNLQHLS VLELTDSGAL MANRFVSSPQ TIVELFFQEV ARKHIISHLF SQPKAPLSQT GLNWPEMITA ITSYLLQLLW PSNPGCLFLE CLMGNCQYV QLQDYIQLLH PWCQVNVGSC RFMLGRCYLV TGEGQKALEC FCQAASEVGK EEFLDRLIRS EDGEIVSTPR L QYYDKVLR LLDVIGLPEL VIQLATSAIT EAGDDWKSQA TLRTCIFKHH LDLGHNSQAY EALTQIPDSS RQLDCLRQLV VV LCERSQL QDLVEFPYVN LHNEVVGIIE SRARAVDLMT HNYYELLYAF HIYRHNYRKA GTVMFEYGMR LGREVRTLRG LEK QGNCYL AALNCLRLIR PEYAWIVQPV SGAVYDRPGA SPKRNHDGEC TAAPTNRQIE ILELEDLEKE CSLARIRLTL AQHD PSAVA VAGSSSAEEM VTLLVQAGLF DTAISLCQTF KLPLTPVFEG LAFKCIKLQF GGEAAQAEAW AWLAANQLSS VITTK ESSA TDEAWRLLST YLERYKVQNN LYHHCVINKL LSHGVPLPNW LINSYKKVDA AELLRLYLNY DLLEEAVDLV SEYVDA VLG KGHQYFGIEF PLSATAPMVW LPYSSIDQLL QALGENSANS HNIALSQKIL DKLEDYQQKV DKATRDLLYR RTL

UniProtKB: Nuclear pore complex protein Nup160

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分子 #21: Nucleoporin Nup37

分子名称: Nucleoporin Nup37 / タイプ: protein_or_peptide / ID: 21 / コピー数: 4 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 36.748512 KDa
配列文字列: MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSL PPVIKFCTSA ADMKIRLFTS DLQDKNEYKV LEGHTDFING LVFDPKEGQE IASVSDDHTC RIWNLEGVQT A HFVLHSPG ...文字列:
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSL PPVIKFCTSA ADMKIRLFTS DLQDKNEYKV LEGHTDFING LVFDPKEGQE IASVSDDHTC RIWNLEGVQT A HFVLHSPG MSVCWHPEET FKLMVAEKNG TIRFYDLLAQ QAILSLESEQ VPLMSAHWCL KNTFKVGAVA GNDWLIWDIT RS SYPQNKR PVHMDRACLF RWSTISENLF ATTGYPGKMA SQFQIHHLGH PQPILMGSVA VGSGLSWHRT LPLCVIGGDH KLL FWVTEV

UniProtKB: Nucleoporin Nup37

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分子 #22: Protein ELYS

分子名称: Protein ELYS / タイプ: protein_or_peptide / ID: 22 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 252.807984 KDa
配列文字列: MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSI TGERLSAYRF SGVNEQPPVV LAVKEFSWQ KRTGLLIGLE ETEGSVLCLY DLGISKVVKA VVLPGRVTAI EPIINHGGAS ASTQHLHPSL RWLFGVAAVV T DVGQILLV ...文字列:
MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSI TGERLSAYRF SGVNEQPPVV LAVKEFSWQ KRTGLLIGLE ETEGSVLCLY DLGISKVVKA VVLPGRVTAI EPIINHGGAS ASTQHLHPSL RWLFGVAAVV T DVGQILLV DLCLDDLSCN QNEVEASDLE VLTGIPAEVP HIRESVMRQG RHLCFQLVSP TGTAVSTLSY ISRTNQLAVG FS DGYLALW NMKSMKREYY IQLESGQVPV YAVTFQEPEN DPRNCCYLWA VQSTQDSEGD VLSLHLLQLA FGNRKCLASG QIL YEGLEY CEERYTLDLT GGMFPLRGQT SNTKLLGCQS IEKFRSHGDR EEGVNEALSP DTSVSVFTWQ VNIYGQGKPS VYLG LFDIN RWYHAQMPDS LRSGEYLHNC SYFALWSLES VVSRTSPHGI LDILVHERSL NRGVPPSYPP PEQFFNPSTY NFDAT CLLN SGVVHLTCTG FQKETLTFLK KSGPSLNELI PDGYNRCLVA GLLSPRFVDV QPSSLSQEEQ LEAILSAAIQ TSSLGL LTG YIRRWITEEQ PNSATNLRFV LEWTWNKVVL TKEEFDRLCV PLFDGSCHFM DPQTIQSIQQ CYLLLSNLNI VLSCFAS EA REITERGLID LSNKFVVSHL ICQYAQVVLW FSHSGLLPEG IDDSVQLSRL CYNYPVIQNY YTSRRQKFER LSRGKWNP D CLMIDGLVSQ LGERIEKLWK RDEGGTGKYP PASLHAVLDM YLLDGVTEAA KHSITIYLLL DIMYSFPNKT DTPIESFPT VFAISWGQVK LIQGFWLIDH NDYESGLDLL FHPATAKPLS WQHSKIIQAF MSQGEHRQAL RYIQTMKPTV SSGNDVILHL TVLLFNRCM VEAWNFLRQH CNRLNIEELL KHMYEVCQEM GLMEDLLKLP FTDTEQECLV KFLQSSASVQ NHEFLLVHHL Q RANYVPAL KLNQTLKINV MNDRDPRLRE RSLARNSILD QYGKILPRVH RKLAIERAKP YHLSTSSVFR LVSRPKPLSA VP KQVVTGT VLTRSVFINN VLSKIGEVWA SKEPINSTTP FNSSKIEEPS PIVYSLPAPE LPEAFFGTPI SKASQKISRL LDL VVQPVP RPSQCSEFIQ QSSMKSPLYL VSRSLPSSSQ LKGSPQAISR ASELHLLETP LVVKKAKSLA MSVTTSGFSE FTPQ SILRS TLRSTPLASP SPSPGRSPQR LKETRISFVE EDVHPKWIPG AADDSKLEVF TTPKKCAVPV ETEWLKSKDR TTSFF LNSP EKEHQEMDEG SQSLEKLDVS KGNSSVSITS DETTLEYQDA PSPEDLEETV FTASKPKSSS TALTTNVTEQ TEKDGD KDV FASEVTPSDL QKQMGNLEDA ETKDLLVAAE AFSELNHLSP VQGTEASLCA PSVYEGKIFT QKSKVPVLDE GLTSVET YT PAIRANDNKS MADVLGDGGN SSLTISEGPI VSERRLNQEV ALNLKEDHEV EVGVLKESVD LPEEKLPISD SPPDTQEI H VIEQEKLEAQ DSGEEARNLS FNELYPSGTL KLQYNFDTID QQFCDLADNK DTAECDIAEV DGELFVAQSN FTLILEGEE GEVEPGDFAS SDVLPKAANT ATEEKLVCSG ENDNHGQIAN LPSAVTSDQK SQKVDTLPYV PEPIKVAIAE NLLDVIKDTR SKEITSDTM EQSIHETIPL VSQNIMCPTK LVKSAFKTAQ ETSTMTMNVS QVDDVVSSKT RTRGQRIQNV NVKSAQQEAS A DVATPKMP GQSVRKKTRK AKEISEASEN IYSDVRGLSQ NQQIPQNSVT PRRGRRKKEV NQDILENTSS VEQELQITTG RE SKRLKSS QLLEPAVEET TKKEVKVSSV TKRTPRRIKR SVENQESVEI INDLKVSTVT SPSRMIRKLR STNLDASENT GNK QDDKSS DKQLRIKHVR RVRGREVSPS DVREDSNLES SQLTVQAEFD MSAIPRKRGR PRKINPSEDV GSKAVKEERS PKKK EAPSI RRRSTRNTPA KSENVDVGKP ALGKSILVPN EELSMVMSSK KKLTKKTESQ SQKRSLHSVS EERTDEMTHK ETNEQ EERL LATASFTKSS RSSRTRSSKA ILLPDLSEPN NEPLFSPASE VPRKAKAKKI EVPAQLKELV SDLSSQFVIS PPALRS RQK NTSNKNKLED ELKDDAQSVE TLGKPKAKRI RTSKTKQASK NTEKESAWSP PPIEIRLISP LASPADGVKS KPRKTTE VT GTGLGRNRKK LSSYPKQILR RKML

UniProtKB: Protein ELYS

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分子 #23: Nuclear pore complex protein Nup98

分子名称: Nuclear pore complex protein Nup98 / タイプ: protein_or_peptide / ID: 23 / コピー数: 7 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 91.760117 KDa
配列文字列: MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG FGTSTGTAN TLFGTASTGT SLFSSQNNAF AQNKPTGFGN FGTSTSSGGL FGTTNTTSNP FGSTSGSLFG PSSFTAAPTG T TIKFNPPT ...文字列:
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG FGTSTGTAN TLFGTASTGT SLFSSQNNAF AQNKPTGFGN FGTSTSSGGL FGTTNTTSNP FGSTSGSLFG PSSFTAAPTG T TIKFNPPT GTDTMVKAGV STNISTKHQC ITAMKEYESK SLEELRLEDY QANRKGPQNQ VGAGTTTGLF GSSPATSSAT GL FSSSTTN SGFAYGQNKT AFGTSTTGFG TNPGGLFGQQ NQQTTSLFSK PFGQATTTQN TGFSFGNTST IGQPSTNTMG LFG VTQASQ PGGLFGTATN TSTGTAFGTG TGLFGQTNTG FGAVGSTLFG NNKLTTFGSS TTSAPSFGTT SGGLFGNKPT LTLG TNTNT SNFGFGTNTS GNSIFGSKPA PGTLGTGLGA GFGTALGAGQ ASLFGNNQPK IGGPLGTGAF GAPGFNTTTA TLGFG APQA PVALTDPNAS AAQQAVLQQH INSLTYSPFG DSPLFRNPMS DPKKKEERLK PTNPAAQKAL TTPTHYKLTP RPATRV RPK ALQTTGTAKS HLFDGLDDDE PSLANGAFMP KKSIKKLVLK NLNNSNLFSP VNRDSENLAS PSEYPENGER FSFLSKP VD ENHQQDGDED SLVSHFYTNP IAKPIPQTPE SAGNKHSNSN SVDDTIVALN MRAALRNGLE GSSEETSFHD ESLQDDRE E IENNSYHMHP AGIILTKVGY YTIPSMDDLA KITNEKGECI VSDFTIGRKG YGSIYFEGDV NLTNLNLDDI VHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF

UniProtKB: Nuclear pore complex protein Nup98-Nup96

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分子 #24: Nuclear pore complex protein Nup214

分子名称: Nuclear pore complex protein Nup214 / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 213.784828 KDa
配列文字列: MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLV PMKFPIHHLA LSCDNLTLSA CMMSSEYGSI IAFFDVRTFS NEAKQQKRPF AYHKLLKDAG GMVIDMKWNP T VPSMVAVC ...文字列:
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLV PMKFPIHHLA LSCDNLTLSA CMMSSEYGSI IAFFDVRTFS NEAKQQKRPF AYHKLLKDAG GMVIDMKWNP T VPSMVAVC LADGSIAVLQ VTETVKVCAT LPSTVAVTSV CWSPKGKQLA VGKQNGTVVQ YLPTLQEKKV IPCPPFYESD HP VRVLDVL WIGTYVFAIV YAAADGTLET SPDVVMALLP KKEEKHPEIF VNFMEPCYGS CTERQHHYYL SYIEEWDLVL AAS AASTEV SILARQSDQI NWESWLLEDS SRAELPVTDK SDDSLPMGVV VDYTNQVEIT ISDEKTLPPA PVLMLLSTDG VLCP FYMIN QNPGVKSLIK TPERLSLEGE RQPKSPGSTP TTPTSSQAPQ KLDASAAAAP ASLPPSSPAA PIATFSLLPA GGAPT VFSF GSSSLKSSAT VTGEPPSYSS GSDSSKAAPG PGPSTFSFVP PSKASLAPTP AASPVAPSAA SFSFGSSGFK PTLEST PVP SVSAPNIAMK PSFPPSTSAV KVNLSEKFTA AATSTPVSSS QSAPPMSPFS SASKPAASGP LSHPTPLSAP PSSVPLK SS VLPSPSGRSA QGSSSPVPSM VQKSPRITPP AAKPGSPQAK SLQPAVAEKQ GHQWKDSDPV MAGIGEEIAH FQKELEEL K ARTSKACFQV GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD SGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYK QTSLWSLSSA VPSQSSIHSF DSDLESLCNA LLKTTIESHT KSLPKVPAKL SPMKQAQLRN FLAKRKTPPV R STAPASLS RSAFLSQRYY EDLDEVSSTS SVSQSLESED ARTSCKDDEA VVQAPRHAPV VRTPSIQPSL LPHAAPFAKS HL VHGSSPG VMGTSVATSA SKIIPQGADS TMLATKTVKH GAPSPSHPIS APQAAAAAAL RRQMASQAPA VNTLTESTLK NVP QVVNVQ ELKNNPATPS TAMGSSVPYS TAKTPHPVLT PVAANQAKQG SLINSLKPSG PTPASGQLSS GDKASGTAKI ETAV TSTPS ASGQFSKPFS FSPSGTGFNF GIITPTPSSN FTAAQGATPS TKESSQPDAF SSGGGSKPSY EAIPESSPPS GITSA SNTT PGEPAASSSR PVAPSGTALS TTSSKLETPP SKLGELLFPS SLAGETLGSF SGLRVGQADD STKPTNKASS TSLTST QPT KTSGVPSGFN FTAPPVLGKH TEPPVTSSAT TTSVAPPAAT STSSTAVFGS LPVTSAGSSG VISFGGTSLS AGKTSFS FG SQQTNSTVPP SAPPPTTAAT PLPTSFPTLS FGSLLSSATT PSLPMSAGRS TEEATSSALP EKPGDSEVSA SAASLLEE Q QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT TGVPDARTEA VPPASSFSVP GQTAVTAAA ISSAGPVAVE TSSTPIASST TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQ TGSTASTAAA TPQVSSSGFS SPAFGTTAPG VFGQTTFGQA SVFGQSASSA ASVFSFSQPG FSSVPAFGQP A SSTPTSTS GSVFGAASST SSSSSFSFGQ SSPNTGGGLF GQSNAPAFGQ SPGFGQGGSV FGGTSAATTT AATSGFSFCQ AS GFGSSNT GSVFGQAAST GGIVFGQQSS SSSGSVFGSG NTGRGGGFFS GLGGKPSQDA ANKNPFSSAS GGFGSTATSN TSN LFGNSG AKTFGGFASS SFGEQKPTGT FSSGGGSVAS QGFGFSSPNK TGGFGAAPVF GSPPTFGGSP GFGGVPAFGS APAF TSPLG STGGKVFGEG TAAASAGGFG FGSSSNTTSF GTLASQNAPT FGSLSQQTSG FGTQSSGFSG FGSGTGGFSF GSNNS SVQG FGGWRS

UniProtKB: Nuclear pore complex protein Nup214

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分子 #25: Nuclear pore complex protein Nup88

分子名称: Nuclear pore complex protein Nup88 / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 83.644711 KDa
配列文字列: MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGG GEEPALSQYQ RLLCINPPLF EIYQVLLSPT QHHVALIGIK GLMVLELPKR WGKNSEFEGG KSTVNCSTTP V AERFFTSS ...文字列:
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGG GEEPALSQYQ RLLCINPPLF EIYQVLLSPT QHHVALIGIK GLMVLELPKR WGKNSEFEGG KSTVNCSTTP V AERFFTSS TSLTLKHAAW YPSEILDPHV VLLTSDNVIR IYSLREPQTP TNVIILSEAE EESLVLNKGR AYTASLGETA VA FDFGPLA AVPKTLFGQN GKDEVVAYPL YILYENGETF LTYISLLHSP GNIGKLLGPL PMHPAAEDNY GYDACAVLCL PCV PNILVI ATESGMLYHC VVLEGEEEDD HTSEKSWDSR IDLIPSLYVF ECVELELALK LASGEDDPFD SDFSCPVKLH RDPK CPSRY HCTHEAGVHS VGLTWIHKLH KFLGSDEEDK DSLQELSTEQ KCFVEHILCT KPLPCRQPAP IRGFWIVPDI LGPTM ICIT STYECLIWPL LSTVHPASPP LLCTREDVEV AESPLRVLAE TPDSFEKHIR SILQRSVANP AFLKASEKDI APPPEE CLQ LLSRATQVFR EQYILKQDLA KEEIQRRVKL LCDQKKKQLE DLSYCREERK SLREMAERLA DKYEEAKEKQ EDIMNRM KK LLHSFHSELP VLSDSERDMK KELQLIPDQL RHLGNAIKQV TMKKDYQQQK MEKVLSLPKP TIILSAYQRK CIQSILKE E GEHIREMVKQ INDIRNHVNF

UniProtKB: Nuclear pore complex protein Nup88

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析サブトモグラム平均法
試料の集合状態cell

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試料調製

緩衝液pH: 7.5
グリッドモデル: Quantifoil R2/1 / 材質: GOLD / メッシュ: 200 / 支持フィルム - 材質: GOLD / 支持フィルム - トポロジー: HOLEY
凍結凍結剤: ETHANE-PROPANE / チャンバー内湿度: 99 % / チャンバー内温度: 300 K / 装置: LEICA EM GP

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電子顕微鏡法

顕微鏡TFS KRIOS
撮影フィルム・検出器のモデル: GATAN K2 QUANTUM (4k x 4k)
平均電子線量: 3.15 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / 最大 デフォーカス（公称値）: 3.0 µm / 最小 デフォーカス（公称値）: 2.0 µm
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 50.0 Å / 解像度の算出法: FSC 0.5 CUT-OFF / 使用したサブトモグラム数: 150
抽出トモグラム数: 8 / 使用した粒子像数: 30
最終 角度割当タイプ: OTHER

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る