+Open data
-Basic information
Entry | Database: PDB / ID: 7luo | ||||||
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Title | N-terminus of Skp2 bound to Cyclin A | ||||||
Components |
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Keywords | CELL CYCLE / Complex / Cyclin / Ligase / Fusion | ||||||
Function / homology | Function and homology information positive regulation of protein polyubiquitination / Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes / cyclin A2-CDK1 complex / Aberrant regulation of mitotic exit in cancer due to RB1 defects / cell cycle G1/S phase transition / cellular response to luteinizing hormone stimulus / mitotic cell cycle phase transition / Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 / cellular response to leptin stimulus / male pronucleus ...positive regulation of protein polyubiquitination / Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes / cyclin A2-CDK1 complex / Aberrant regulation of mitotic exit in cancer due to RB1 defects / cell cycle G1/S phase transition / cellular response to luteinizing hormone stimulus / mitotic cell cycle phase transition / Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 / cellular response to leptin stimulus / male pronucleus / female pronucleus / cellular response to cocaine / response to glucagon / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / cyclin-dependent protein serine/threonine kinase regulator activity / cellular response to insulin-like growth factor stimulus / SCF ubiquitin ligase complex / positive regulation of intracellular estrogen receptor signaling pathway / positive regulation of DNA biosynthetic process / cochlea development / cellular response to platelet-derived growth factor stimulus / cyclin A2-CDK2 complex / G2 Phase / p53-Dependent G1 DNA Damage Response / regulation of DNA replication / Regulation of APC/C activators between G1/S and early anaphase / Telomere Extension By Telomerase / G0 and Early G1 / cyclin-dependent protein kinase holoenzyme complex / protein K48-linked ubiquitination / cellular response to nitric oxide / animal organ regeneration / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / Regulation of BACH1 activity / post-translational protein modification / cellular response to estradiol stimulus / Cdc20:Phospho-APC/C mediated degradation of Cyclin A / G1/S transition of mitotic cell cycle / APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 / DNA Damage/Telomere Stress Induced Senescence / CDK-mediated phosphorylation and removal of Cdc6 / SCF(Skp2)-mediated degradation of p27/p21 / Orc1 removal from chromatin / Regulation of RUNX2 expression and activity / Cyclin D associated events in G1 / G2/M transition of mitotic cell cycle / positive regulation of fibroblast proliferation / Antigen processing: Ubiquitination & Proteasome degradation / Regulation of TP53 Degradation / Neddylation / Processing of DNA double-strand break ends / cellular response to hypoxia / Senescence-Associated Secretory Phenotype (SASP) / proteasome-mediated ubiquitin-dependent protein catabolic process / regulation of apoptotic process / defense response to virus / Ras protein signal transduction / Regulation of TP53 Activity through Phosphorylation / regulation of cell cycle / Ub-specific processing proteases / cell division / protein domain specific binding / innate immune response / DNA-templated transcription / nucleolus / protein kinase binding / positive regulation of DNA-templated transcription / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.17 Å | ||||||
Authors | Kelso, S. / Ceccarelli, D.F. / Sicheri, F. | ||||||
Funding support | Canada, 1items
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Citation | Journal: Structure / Year: 2021 Title: Bipartite binding of the N terminus of Skp2 to cyclin A. Authors: Kelso, S. / Orlicky, S. / Beenstock, J. / Ceccarelli, D.F. / Kurinov, I. / Gish, G. / Sicheri, F. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7luo.cif.gz | 218.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7luo.ent.gz | 173.6 KB | Display | PDB format |
PDBx/mmJSON format | 7luo.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lu/7luo ftp://data.pdbj.org/pub/pdb/validation_reports/lu/7luo | HTTPS FTP |
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-Related structure data
Related structure data | 1finS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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