- PDB-7l9x: Structure of VPS4B in complex with an allele-specific covalent in... -
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Basic information
Entry
Database: PDB / ID: 7l9x
Title
Structure of VPS4B in complex with an allele-specific covalent inhibitor
Components
Vacuolar protein sorting-associated protein 4BVacuole
Keywords
PROTEIN TRANSPORT / chemical Inhibitor / hydrolase / ATPase / AAA superfamily
Function / homology
Function and homology information
protein depolymerization / positive regulation of centriole elongation / ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway / negative regulation of exosomal secretion / late endosome to lysosome transport via multivesicular body sorting pathway / ESCRT III complex disassembly / late endosomal microautophagy / regulation of centrosome duplication / nuclear membrane reassembly / midbody abscission ...protein depolymerization / positive regulation of centriole elongation / ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway / negative regulation of exosomal secretion / late endosome to lysosome transport via multivesicular body sorting pathway / ESCRT III complex disassembly / late endosomal microautophagy / regulation of centrosome duplication / nuclear membrane reassembly / midbody abscission / establishment of blood-brain barrier / multivesicular body sorting pathway / vacuole organization / membrane fission / plasma membrane repair / positive regulation of exosomal secretion / ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / multivesicular body assembly / endosome to lysosome transport via multivesicular body sorting pathway / cholesterol transport / regulation of mitotic spindle assembly / vesicle-fusing ATPase / Flemming body / endosomal transport / mitotic metaphase chromosome alignment / response to lipid / ATPase complex / nucleus organization / viral budding via host ESCRT complex / autophagosome maturation / canonical Wnt signaling pathway / nuclear pore / Endosomal Sorting Complex Required For Transport (ESCRT) / positive regulation of G2/M transition of mitotic cell cycle / viral budding from plasma membrane / macroautophagy / Budding and maturation of HIV virion / potassium ion transport / autophagy / spindle pole / protein transport / late endosome membrane / midbody / angiogenesis / endosome membrane / endosome / centrosome / protein-containing complex binding / protein homodimerization activity / ATP hydrolysis activity / extracellular exosome / ATP binding / identical protein binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function
Vacuolar protein sorting-associated protein 4, MIT domain / MIT (microtubule interacting and transport) domain / MIT domain superfamily / Vps4 oligomerisation, C-terminal / MIT domain / Microtubule Interacting and Trafficking molecule domain / Vps4 C terminal oligomerisation domain / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site ...Vacuolar protein sorting-associated protein 4, MIT domain / MIT (microtubule interacting and transport) domain / MIT domain superfamily / Vps4 oligomerisation, C-terminal / MIT domain / Microtubule Interacting and Trafficking molecule domain / Vps4 C terminal oligomerisation domain / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology
Vacuolarproteinsorting-associatedprotein4B / Vacuole / Cell migration-inducing gene 1 protein / Suppressor of K(+) transport growth defect 1 / Protein SKD1
Mass: 49586.258 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: VPS4B, SKD1, VPS42, MIG1 / Production host: Escherichia coli (E. coli) / References: UniProt: O75351, vesicle-fusing ATPase
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