+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 6wc2 | ||||||
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タイトル | Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex | ||||||
要素 |
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キーワード | TRANSCRIPTION (転写 (生物学)) / Transcription Factor (転写因子) / DNA binding Protein (DNA結合タンパク質) / Cardiogenesis / Carcinogenesis | ||||||
機能・相同性 | 機能・相同性情報 Nkx-2.5 complex / Purkinje myocyte differentiation / right ventricular cardiac muscle tissue morphogenesis / septum secundum development / proepicardium development / pulmonary myocardium development / cardiac ventricle formation / apoptotic process involved in heart morphogenesis / atrioventricular node cell fate commitment / bundle of His development ...Nkx-2.5 complex / Purkinje myocyte differentiation / right ventricular cardiac muscle tissue morphogenesis / septum secundum development / proepicardium development / pulmonary myocardium development / cardiac ventricle formation / apoptotic process involved in heart morphogenesis / atrioventricular node cell fate commitment / bundle of His development / atrial cardiac muscle cell development / ERK5 cascade / ventricular cardiac myofibril assembly / mitochondrion distribution / atrioventricular node cell development / embryonic heart tube left/right pattern formation / positive regulation of cardioblast differentiation / atrial cardiac muscle tissue development / atrioventricular node development / ventricular cardiac muscle cell development / regulation of cardiac muscle cell proliferation / atrial septum morphogenesis / positive regulation of heart contraction / Physiological factors / negative regulation of myotube differentiation / cardiac conduction system development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / cardiac conduction / mitochondrial genome maintenance / pharyngeal system development / positive regulation of sodium ion transport / negative regulation of epithelial cell apoptotic process / outflow tract septum morphogenesis / ventricular trabecula myocardium morphogenesis / cardiac muscle tissue morphogenesis / heart trabecula formation / adult heart development / embryonic heart tube development / aortic valve morphogenesis / cardiac muscle cell development / dendrite morphogenesis / Cardiogenesis / negative regulation of cardiac muscle cell apoptotic process / muscle organ development / cardiac muscle cell proliferation / epithelial cell apoptotic process / histone acetyltransferase binding / DNA-binding transcription activator activity / ventricular septum morphogenesis / positive regulation of cardiac muscle hypertrophy / Myogenesis / heart looping / cardiac septum morphogenesis / ERK/MAPK targets / SMAD binding / thyroid gland development / 造血 / regulation of cardiac conduction / positive regulation of transcription initiation by RNA polymerase II / regulation of cardiac muscle contraction / 脈管形成 / heart morphogenesis / cardiac muscle contraction / spleen development / epithelial cell differentiation / cellular response to calcium ion / positive regulation of neuron differentiation / epithelial cell proliferation / positive regulation of epithelial cell proliferation / デオキシリボ核酸 / positive regulation of glucose import / RNA polymerase II transcription regulatory region sequence-specific DNA binding / negative regulation of canonical Wnt signaling pathway / histone deacetylase binding / RNA polymerase II transcription regulator complex / 分裂促進因子活性化タンパク質キナーゼ / sequence-specific double-stranded DNA binding / 細胞結合 / heart development / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / transcription regulator complex / RNA polymerase II-specific DNA-binding transcription factor binding / sequence-specific DNA binding / transcription by RNA polymerase II / 細胞分化 / transcription cis-regulatory region binding / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein heterodimerization activity / negative regulation of DNA-templated transcription / DNA-templated transcription / apoptotic process / chromatin binding / positive regulation of cell population proliferation / クロマチン / positive regulation of gene expression / regulation of DNA-templated transcription 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) synthetic construct (人工物) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å | ||||||
データ登録者 | Lei, X. / Chen, L. | ||||||
資金援助 | 米国, 1件
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引用 | ジャーナル: J.Mol.Biol. / 年: 2020 タイトル: Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. 著者: Lei, X. / Zhao, J. / Sagendorf, J.M. / Rajashekar, N. / Xu, J. / Dantas Machado, A.C. / Sen, C. / Rohs, R. / Feng, P. / Chen, L. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6wc2.cif.gz | 454.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6wc2.ent.gz | 367.3 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 6wc2.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/wc/6wc2 ftp://data.pdbj.org/pub/pdb/validation_reports/wc/6wc2 | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域: Component-ID: 0 / Refine code: 0
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