+Open data
-Basic information
Entry | Database: PDB / ID: 6v0z | ||||||
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Title | Structure of ALDH7A1 mutant R441C complexed with NAD | ||||||
Components | Alpha-aminoadipic semialdehyde dehydrogenase | ||||||
Keywords | OXIDOREDUCTASE / ALDEHYDE DEHYDROGENASE / NAD / LYSINE CATABOLISM | ||||||
Function / homology | Function and homology information L-aminoadipate-semialdehyde dehydrogenase / L-aminoadipate-semialdehyde dehydrogenase activity / Choline catabolism / choline catabolic process / betaine-aldehyde dehydrogenase / betaine-aldehyde dehydrogenase activity / Lysine catabolism / glycine betaine biosynthetic process from choline / cellular aldehyde metabolic process / glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity ...L-aminoadipate-semialdehyde dehydrogenase / L-aminoadipate-semialdehyde dehydrogenase activity / Choline catabolism / choline catabolic process / betaine-aldehyde dehydrogenase / betaine-aldehyde dehydrogenase activity / Lysine catabolism / glycine betaine biosynthetic process from choline / cellular aldehyde metabolic process / glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity / aldehyde dehydrogenase (NAD+) / aldehyde dehydrogenase (NAD+) activity / sensory perception of sound / mitochondrial matrix / mitochondrion / extracellular exosome / identical protein binding / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.02 Å | ||||||
Authors | Korasick, D.A. / Tanner, J.J. | ||||||
Funding support | United States, 1items
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Citation | Journal: Chem.Biol.Interact. / Year: 2024 Title: Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1. Authors: Korasick, D.A. / Buckley, D.P. / Palpacelli, A. / Cursio, I. / Cesaroni, E. / Cheng, J. / Tanner, J.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6v0z.cif.gz | 1.5 MB | Display | PDBx/mmCIF format |
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PDB format | pdb6v0z.ent.gz | 1.2 MB | Display | PDB format |
PDBx/mmJSON format | 6v0z.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/v0/6v0z ftp://data.pdbj.org/pub/pdb/validation_reports/v0/6v0z | HTTPS FTP |
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-Related structure data
Related structure data | 4zukS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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