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- PDB-6ptw: NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6ptw | ||||||
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Title | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B) | ||||||
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Function / homology | ![]() Defective ABCA1 causes TGD / Scavenging by Class B Receptors / HDL clearance / high-density lipoprotein particle receptor binding / spherical high-density lipoprotein particle / positive regulation of hydrolase activity / negative regulation of response to cytokine stimulus / regulation of intestinal cholesterol absorption / protein oxidation / vitamin transport ...Defective ABCA1 causes TGD / Scavenging by Class B Receptors / HDL clearance / high-density lipoprotein particle receptor binding / spherical high-density lipoprotein particle / positive regulation of hydrolase activity / negative regulation of response to cytokine stimulus / regulation of intestinal cholesterol absorption / protein oxidation / vitamin transport / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Fang, Z. / Lee, K. / Gasmi-Seabrook, G. / Ikura, M. / Marshall, C.B. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. Authors: Fang, Z. / Lee, K.Y. / Huo, K.G. / Gasmi-Seabrook, G. / Zheng, L. / Moghal, N. / Tsao, M.S. / Ikura, M. / Marshall, C.B. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 2.2 MB | Display | ![]() |
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PDB format | ![]() | 1.9 MB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 6ptsC C: citing same article ( |
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Similar structure data | |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
-Protein , 3 types, 4 molecules ACBD
#1: Protein | ![]() Mass: 23080.129 Da / Num. of mol.: 2 / Fragment: UNP residues 68-265 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #2: Protein | | Mass: 21116.119 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #3: Protein | | Mass: 15266.923 Da / Num. of mol.: 1 / Fragment: RBD-CRD (UNP residues 56-187) Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() |
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-Non-polymers , 5 types, 84 molecules ![](data/chem/img/PCW.gif)
![](data/chem/img/17F.gif)
![](data/chem/img/GNP.gif)
![](data/chem/img/MG.gif)
![](data/chem/img/ZN.gif)
![](data/chem/img/17F.gif)
![](data/chem/img/GNP.gif)
![](data/chem/img/MG.gif)
![](data/chem/img/ZN.gif)
#4: Chemical | ChemComp-PCW / #5: Chemical | ChemComp-17F / #6: Chemical | ChemComp-GNP / | ![]() #7: Chemical | ChemComp-MG / | #8: Chemical | |
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-Experimental details
-Experiment
Experiment | Method: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details |
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Sample |
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Sample conditions |
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-NMR measurement
NMR spectrometer | Type: Bruker AVANCE III / Manufacturer: Bruker / Model![]() |
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Processing
NMR software |
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Refinement | Method: ![]() | |||||||||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | |||||||||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 3000 / Conformers submitted total number: 10 |