登録情報 | データベース: PDB / ID: 6p8g |
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タイトル | Crystal structure of CDK4 in complex with CyclinD1 and P27 |
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要素 | - Cyclin-dependent kinase 4サイクリン依存性キナーゼ4
- Cyclin-dependent kinase inhibitor 1B
- G1/S-specific cyclin-D1
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キーワード | cell cycle (細胞周期) / transferase (転移酵素) / Cyclin-dependent kinase (サイクリン依存性キナーゼ) / kinase inhibitor |
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機能・相同性 | 機能・相同性情報
re-entry into mitotic cell cycle / cyclin-dependent protein kinase activating kinase regulator activity / regulation of lens fiber cell differentiation / cyclin D3-CDK4 complex / cyclin D1-CDK4 complex / cyclin D2-CDK4 complex / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / negative regulation of cardiac muscle tissue regeneration / negative regulation of cyclin-dependent protein kinase activity ...re-entry into mitotic cell cycle / cyclin-dependent protein kinase activating kinase regulator activity / regulation of lens fiber cell differentiation / cyclin D3-CDK4 complex / cyclin D1-CDK4 complex / cyclin D2-CDK4 complex / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / negative regulation of cardiac muscle tissue regeneration / negative regulation of cyclin-dependent protein kinase activity / cellular response to ionomycin / regulation of transcription initiation by RNA polymerase II / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / regulation of type B pancreatic cell proliferation / autophagic cell death / RUNX3 regulates WNT signaling / response to leptin / negative regulation of epithelial cell proliferation involved in prostate gland development / FOXO-mediated transcription of cell cycle genes / positive regulation of mammary gland epithelial cell proliferation / regulation of cell cycle G1/S phase transition / regulation of exit from mitosis / cellular response to phorbol 13-acetate 12-myristate / Transcriptional regulation by RUNX2 / epithelial cell proliferation involved in prostate gland development / mitotic cell cycle phase transition / negative regulation of epithelial cell apoptotic process / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of phosphorylation / ubiquitin ligase activator activity / cyclin-dependent protein serine/threonine kinase inhibitor activity / RHO GTPases activate CIT / cyclin-dependent protein serine/threonine kinase activator activity / 核外搬出シグナル / proline-rich region binding / Regulation of RUNX1 Expression and Activity / AKT phosphorylates targets in the cytosol / cyclin-dependent protein serine/threonine kinase regulator activity / mammary gland epithelial cell proliferation / Cul4A-RING E3 ubiquitin ligase complex / response to UV-A / epithelial cell apoptotic process / cellular response to antibiotic / negative regulation of epithelial cell differentiation / negative regulation of kinase activity / cellular response to lithium ion / molecular function inhibitor activity / protein kinase inhibitor activity / fat cell differentiation / p53-Dependent G1 DNA Damage Response / PTK6 Regulates Cell Cycle / regulation of cyclin-dependent protein serine/threonine kinase activity / Constitutive Signaling by AKT1 E17K in Cancer / regulation of G1/S transition of mitotic cell cycle / negative regulation of vascular associated smooth muscle cell proliferation / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / inner ear development / RUNX3 regulates p14-ARF / cellular response to organic cyclic compound / positive regulation of cyclin-dependent protein serine/threonine kinase activity / Transcriptional Regulation by VENTX / negative regulation of mitotic cell cycle / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / cyclin-dependent protein kinase holoenzyme complex / bicellular tight junction / mammary gland alveolus development / cellular response to interleukin-4 / response to amino acid / localization / サイクリン依存性キナーゼ / cyclin-dependent protein serine/threonine kinase activity / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / response to glucose / response to cadmium ion / Cyclin E associated events during G1/S transition / Cyclin A:Cdk2-associated events at S phase entry / endoplasmic reticulum unfolded protein response / positive regulation of microtubule polymerization / regulation of cell migration / Notchシグナリング / mitotic G1 DNA damage checkpoint signaling / Hsp70 protein binding / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / regulation of G2/M transition of mitotic cell cycle / positive regulation of G2/M transition of mitotic cell cycle / 授乳 / transcription repressor complex / FLT3 Signaling / cyclin binding / : / positive regulation of DNA replication / Ubiquitin-dependent degradation of Cyclin D / liver regeneration / placenta development / sensory perception of sound / neuron differentiation / potassium ion transport / Oncogene Induced Senescence類似検索 - 分子機能 Cyclin-dependent kinase inhibitor domain / Cyclin-dependent kinase inhibitor domain superfamily / サイクリン依存性キナーゼ阻害因子 / Cyclin, C-terminal domain / : / Cyclins signature. / サイクリン / Cyclin, C-terminal domain / Cyclin_C / Cyclin-like ...Cyclin-dependent kinase inhibitor domain / Cyclin-dependent kinase inhibitor domain superfamily / サイクリン依存性キナーゼ阻害因子 / Cyclin, C-terminal domain / : / Cyclins signature. / サイクリン / Cyclin, C-terminal domain / Cyclin_C / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 サイクリン依存性キナーゼ4 / G1/S-specific cyclin-D1 / Cyclin-dependent kinase inhibitor 1B類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Guiley, K.Z. / Stevenson, J.W. / Lou, K. / Barkovich, K.J. / Bunch, K. / Tripathi, S.M. / Shokat, K.M. / Rubin, S.M. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | GM124148 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA206244 | 米国 |
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引用 | ジャーナル: Science / 年: 2019 タイトル: p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. 著者: Guiley, K.Z. / Stevenson, J.W. / Lou, K. / Barkovich, K.J. / Kumarasamy, V. / Wijeratne, T.U. / Bunch, K.L. / Tripathi, S. / Knudsen, E.S. / Witkiewicz, A.K. / Shokat, K.M. / Rubin, S.M. |
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履歴 | 登録 | 2019年6月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年12月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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