Entry Database : PDB / ID : 1s70 Structure visualization Downloads & linksTitle Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1) Components130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130) Serine/threonine protein phosphatase PP1-beta (or delta) catalytic subunit Serine/threonine-specific protein kinase DetailsKeywords HYDROLASE / myosin phosphatase / MYPT1 / PP1 / myosin regulation / deposphorylationFunction / homology Function and homology informationFunction Domain/homology Component
[myosin-light-chain] phosphatase / myosin-light-chain-phosphatase activity / Signaling by MRAS-complex mutants / regulation of myosin-light-chain-phosphatase activity / positive regulation of myosin-light-chain-phosphatase activity / phosphatase regulator activity / chromosome, telomeric region => GO:0000781 / protein serine/threonine phosphatase activity => GO:0004722 / protein serine/threonine phosphatase activity => GO:0004722 / protein phosphatase type 1 complex ... [myosin-light-chain] phosphatase / myosin-light-chain-phosphatase activity / Signaling by MRAS-complex mutants / regulation of myosin-light-chain-phosphatase activity / positive regulation of myosin-light-chain-phosphatase activity / phosphatase regulator activity / chromosome, telomeric region => GO:0000781 / protein serine/threonine phosphatase activity => GO:0004722 / protein serine/threonine phosphatase activity => GO:0004722 / protein phosphatase type 1 complex / regulation of glycogen catabolic process / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / RHO GTPases Activate ROCKs / RHO GTPases activate CIT / enzyme inhibitor activity / A band / myosin phosphatase activity / protein serine/threonine phosphatase activity / glycogen metabolic process / protein-serine/threonine phosphatase / Triglyceride catabolism / entrainment of circadian clock by photoperiod / phosphatase activity / RHO GTPases activate PAKs / regulation of cell adhesion / RHO GTPases activate PKNs / 14-3-3 protein binding / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / RAF activation / circadian regulation of gene expression / regulation of circadian rhythm / Z disc / G2/M transition of mitotic cell cycle / Regulation of PLK1 Activity at G2/M Transition / Circadian Clock / cytoskeleton / cell cycle / cell division / focal adhesion / nucleolus / protein kinase binding / signal transduction / extracellular exosome / nucleoplasm / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Protein phosphatase 1 regulatory subunit 12A/B/C / cGMP-dependent protein kinase, interacting domain / cGMP-dependent protein kinase interacting domain / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / Domain of unknown function DUF3447 / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases ... Protein phosphatase 1 regulatory subunit 12A/B/C / cGMP-dependent protein kinase, interacting domain / cGMP-dependent protein kinase interacting domain / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / Domain of unknown function DUF3447 / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Ankyrin repeat-containing domain / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / 4-Layer Sandwich / Alpha Horseshoe / Mainly Alpha / Alpha Beta Similarity search - Domain/homology : / TRIETHYLENE GLYCOL / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / Protein phosphatase 1 regulatory subunit 12A / Protein phosphatase 1 regulatory subunit 12A Similarity search - ComponentBiological species Homo sapiens (human)Gallus gallus (chicken)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Kerff, F. / Terrak, M. / Dominguez, R. CitationJournal : Nature / Year : 2004Title : Structural basis of protein phosphatase 1 regulationAuthors : Terrak, M. / Kerff, F. / Langsetmo, K. / Tao, T. / Dominguez, R. History Deposition Jan 28, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 22, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Oct 27, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Aug 23, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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