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- PDB-6lw5: Crystal structure of the human formyl peptide receptor 2 in compl... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6lw5 | |||||||||||||||
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Title | Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm | |||||||||||||||
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Function / homology | ![]() N-formyl peptide receptor activity / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | |||||||||||||||
Biological species | ![]() ![]() ![]() ![]() ![]() synthetic construct (others) | |||||||||||||||
Method | ![]() ![]() ![]() | |||||||||||||||
![]() | Chen, T. / Zong, X. / Zhang, H. / Wang, M. / Zhao, Q. / Wu, B. | |||||||||||||||
Funding support | ![]()
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![]() | ![]() Title: Structural basis of ligand binding modes at the human formyl peptide receptor 2. Authors: Chen, T. / Xiong, M. / Zong, X. / Ge, Y. / Zhang, H. / Wang, M. / Won Han, G. / Yi, C. / Ma, L. / Ye, R.D. / Xu, Y. / Zhao, Q. / Wu, B. | |||||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 100.1 KB | Display | ![]() |
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PDB format | ![]() | 74.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Components
#1: Protein | Mass: 47694.016 Da / Num. of mol.: 1 / Mutation: M1007W, H1102I, R1106L, S211L Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() Gene: cybC, FPR2, FPRH1, FPRL1, LXA4R Production host: Mammalian expression vector Flag-MCS-pcDNA3.1 (others) References: UniProt: P0ABE7, UniProt: P25090 | ||||
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#2: Protein/peptide | Mass: 857.117 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others) | ||||
#3: Chemical | ![]() #4: Water | ChemComp-HOH / | ![]() Has ligand of interest | Y | |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.26 Å3/Da / Density % sol: 62.22 % |
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Crystal grow![]() | Temperature: 293 K / Method: lipidic cubic phase Details: 0.1 M Tris, pH 7.5, 35% PEG500 DME, 3% PPG400, 100 mM CH3COOLi |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Feb 14, 2018 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.8→30 Å / Num. obs: 15644 / % possible obs: 96.5 % / Redundancy: 7.9 % / CC1/2: 0.99 / Net I/σ(I): 6.8 |
Reflection shell | Resolution: 2.8→2.85 Å / Num. unique obs: 767 / CC1/2: 0.82 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 5C1M, 1M6T Resolution: 2.8→30 Å / Cross valid method: FREE R-VALUE
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Refinement step | Cycle: LAST / Resolution: 2.8→30 Å
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LS refinement shell | Resolution: 2.8→2.97 Å
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