登録情報 | データベース: PDB / ID: 6hyt |
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タイトル | Crystal structure of DHX8 helicase domain bound to ADP at 2.3 Angstrom |
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要素 | ATP-dependent RNA helicase DHX8 |
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キーワード | RNA BINDING PROTEIN (RNA結合タンパク質) / helicase (ヘリカーゼ) / splicing / RNA (リボ核酸) |
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機能・相同性 | 機能・相同性情報
spliceosomal complex disassembly / ATP-dependent activity, acting on RNA / U2-type catalytic step 2 spliceosome / 転写後修飾 / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / RNA splicing / spliceosomal complex / mRNA splicing, via spliceosome / RNA helicase activity ...spliceosomal complex disassembly / ATP-dependent activity, acting on RNA / U2-type catalytic step 2 spliceosome / 転写後修飾 / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / RNA splicing / spliceosomal complex / mRNA splicing, via spliceosome / RNA helicase activity / nuclear body / ヘリカーゼ / ATP hydrolysis activity / RNA binding / 核質 / ATP binding / identical protein binding / 細胞核 / 細胞質基質類似検索 - 分子機能 DHX8/ Prp22, DEXH-box helicase domain / : / : / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation ...DHX8/ Prp22, DEXH-box helicase domain / : / : / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / S1 domain profile. / Ribosomal protein S1-like RNA-binding domain / S1 RNA binding domain / S1 domain / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Nucleic acid-binding, OB-fold / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 酢酸塩 / ADENOSINE-5'-DIPHOSPHATE / ATP-dependent RNA helicase DHX8類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.33 Å |
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データ登録者 | Felisberto-Rodrigues, C. / Thomas, J.C. / McAndrew, P.C. / Le Bihan, Y.V. / Burke, R. / Workman, P. / van Montfort, R.L.M. |
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資金援助 | 英国, 2件 組織 | 認可番号 | 国 |
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Cancer Research UK | C309/A11566 | 英国 | Cancer Research UK | C2739/A22897 | 英国 |
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引用 | ジャーナル: Biochem.J. / 年: 2019 タイトル: Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. 著者: Felisberto-Rodrigues, C. / Thomas, J.C. / McAndrew, C. / Le Bihan, Y.V. / Burke, R. / Workman, P. / van Montfort, R.L.M. |
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履歴 | 登録 | 2018年10月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年8月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年9月25日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2024年5月15日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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