- PDB-6gkf: Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 bindin... -
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基本情報
登録情報
データベース: PDB / ID: 6gkf
タイトル
Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139
要素
14-3-3 protein gamma
Caspase-2カスパーゼ-2
キーワード
SIGNALING PROTEIN / complex / phosphorylation (リン酸化) / 14-3-3 protein (14-3-3タンパク質) / caspase-2 (カスパーゼ-2)
機能・相同性
機能・相同性情報
カスパーゼ-2 / endopeptidase complex / neural retina development / NADE modulates death signalling / luteolysis / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cysteine-type endopeptidase activity involved in execution phase of apoptosis / execution phase of apoptosis / regulation of neuron differentiation / protein kinase C inhibitor activity ...カスパーゼ-2 / endopeptidase complex / neural retina development / NADE modulates death signalling / luteolysis / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cysteine-type endopeptidase activity involved in execution phase of apoptosis / execution phase of apoptosis / regulation of neuron differentiation / protein kinase C inhibitor activity / TP53 Regulates Transcription of Caspase Activators and Caspases / Regulation of localization of FOXO transcription factors / phosphoserine residue binding / protein targeting / Activation of BAD and translocation to mitochondria / regulation of signal transduction / ectopic germ cell programmed cell death / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / positive regulation of apoptotic signaling pathway / RHO GTPases activate PKNs / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / negative regulation of TORC1 signaling / extrinsic apoptotic signaling pathway in absence of ligand / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / insulin-like growth factor receptor binding / Anchoring of the basal body to the plasma membrane / AURKA Activation by TPX2 / protein sequestering activity / protein kinase C binding / Translocation of SLC2A4 (GLUT4) to the plasma membrane / apoptotic signaling pathway / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / regulation of synaptic plasticity / NOD1/2 Signaling Pathway / protein processing / receptor tyrosine kinase binding / cellular response to mechanical stimulus / cellular response to insulin stimulus / positive regulation of neuron apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / Regulation of PLK1 Activity at G2/M Transition / presynapse / positive regulation of apoptotic process / protein domain specific binding / cysteine-type endopeptidase activity / focal adhesion / apoptotic process / DNA damage response / 核小体 / negative regulation of apoptotic process / enzyme binding / シグナル伝達 / RNA binding / extracellular exosome / 生体膜 / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能
カスパーゼ-2 / Caspase recruitment domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 ...カスパーゼ-2 / Caspase recruitment domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3タンパク質 / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3タンパク質 / Death-like domain superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性