登録情報 データベース : PDB / ID : 6but 構造の表示 ダウンロードとリンクタイトル Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2 要素Calmodulin-1 カルモジュリン Sodium channel protein type 2 subunit alpha ナトリウムチャネル 詳細キーワード MEMBRANE PROTEIN (膜タンパク質) / Calcium-Binding Protein (カルシウム結合タンパク質) / METAL TRANSPORT Ion channel Neuronal Molecular recognition機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
intrinsic apoptotic signaling pathway in response to osmotic stress / nerve development / high voltage-gated calcium channel activity / paranode region of axon / dentate gyrus development / ランヴィエの絞輪 / voltage-gated sodium channel complex / Interaction between L1 and Ankyrins / CAM型光合成 / Cam-PDE 1 activation ... intrinsic apoptotic signaling pathway in response to osmotic stress / nerve development / high voltage-gated calcium channel activity / paranode region of axon / dentate gyrus development / ランヴィエの絞輪 / voltage-gated sodium channel complex / Interaction between L1 and Ankyrins / CAM型光合成 / Cam-PDE 1 activation / Sodium/Calcium exchangers / voltage-gated sodium channel activity / Calmodulin induced events / Reduction of cytosolic Ca++ levels / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Activation of Ca-permeable Kainate Receptor / Loss of phosphorylation of MECP2 at T308 / voltage-gated calcium channel complex / CREB1 phosphorylation through the activation of Adenylate Cyclase / PKA activation / negative regulation of high voltage-gated calcium channel activity / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / Activation of RAC1 downstream of NMDARs / mitochondrion-endoplasmic reticulum membrane tethering / CLEC7A (Dectin-1) induces NFAT activation / regulation of cardiac muscle cell action potential / autophagosome membrane docking / sodium ion transport / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / Negative regulation of NMDA receptor-mediated neuronal transmission / negative regulation of peptidyl-threonine phosphorylation / Synthesis of IP3 and IP4 in the cytosol / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / protein phosphatase activator activity / RHO GTPases activate PAKs / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of phosphoprotein phosphatase activity / Ion transport by P-type ATPases / 長期増強 / calcium ion import across plasma membrane / Uptake and function of anthrax toxins / Regulation of MECP2 expression and activity / Calcineurin activates NFAT / catalytic complex / 介在板 / DARPP-32 events / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity / neuronal action potential / Smooth Muscle Contraction / RHO GTPases activate IQGAPs / regulation of cardiac muscle contraction / calcium channel inhibitor activity / cellular response to interferon-beta / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / Protein methylation / eNOS activation / Activation of AMPK downstream of NMDARs / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of calcium-mediated signaling / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / positive regulation of protein dephosphorylation / voltage-gated potassium channel complex / Ion homeostasis / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / positive regulation of protein autophosphorylation / sperm midpiece / 横行小管 / calcium channel complex / substantia nigra development / adenylate cyclase activator activity / 髄鞘 / Ras activation upon Ca2+ influx through NMDA receptor / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / VEGFR2 mediated vascular permeability / positive regulation of peptidyl-threonine phosphorylation / regulation of cytokinesis / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / VEGFR2 mediated cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / determination of adult lifespan / RAF activation / positive regulation of receptor signaling pathway via JAK-STAT / Transcriptional activation of mitochondrial biogenesis / positive regulation of protein serine/threonine kinase activity / spindle microtubule / Stimuli-sensing channels / 記憶 / Sensory perception of sweet, bitter, and umami (glutamate) taste / cellular response to type II interferon 類似検索 - 分子機能 Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif profile. / IQ motif, EF-hand binding site ... Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif profile. / IQ motif, EF-hand binding site / Voltage-dependent channel domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Ion transport domain / Ion transport protein / EF-hand domain pair 類似検索 - ドメイン・相同性 Calmodulin-1 / Sodium channel protein type 2 subunit alpha 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / molecular dynamics 詳細データ登録者 Mahling, R. / Kilpatrick, A.M. / Shea, M.A. 資金援助 米国, 2件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01 GM57001 米国 National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) T32 NS045549 米国
引用ジャーナル : Structure / 年 : 2021タイトル : Na V 1.2 EFL domain allosterically enhances Ca 2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.
著者 :
Mahling, R. / Hovey, L. / Isbell, H.M. / Marx, D.C. / Miller, M.S. / Kilpatrick, A.M. / Weaver, L.D. / Yoder, J.B. / Kim, E.H. / Andresen, C.N.J. / Li, S. / Shea, M.A. 残り1件を表示 表示を減らす#1: ジャーナル : Biomol NMR Assign / 年 : 2017タイトル : Backbone resonance assignments of complexes of human voltage-dependent sodium channel NaV1.2 IQ motif peptide bound to apo calmodulin and to the C-domain fragment of apo calmodulin.
著者 :
Mahling, R. / Kilpatrick, A.M. / Shea, M.A. 履歴 登録 2017年12月11日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年6月19日 Provider : repository / タイプ : Initial release改定 1.1 2019年12月18日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.2 2021年4月21日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.3 2024年5月1日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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