登録情報 | データベース: PDB / ID: 6alz |
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タイトル | Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin |
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要素 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Inhibitor / complex / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
regulation of glycogen catabolic process / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / telomere maintenance in response to DNA damage / protein phosphatase 1 binding / cadherin binding involved in cell-cell adhesion / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / regulation of canonical Wnt signaling pathway / regulation of translational initiation ...regulation of glycogen catabolic process / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / telomere maintenance in response to DNA damage / protein phosphatase 1 binding / cadherin binding involved in cell-cell adhesion / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / regulation of canonical Wnt signaling pathway / regulation of translational initiation / myosin phosphatase activity / branching morphogenesis of an epithelial tube / protein serine/threonine phosphatase activity / glycogen metabolic process / protein-serine/threonine phosphatase / dephosphorylation / Triglyceride catabolism / Maturation of hRSV A proteins / entrainment of circadian clock by photoperiod / phosphatase activity / phosphoprotein phosphatase activity / DARPP-32 events / ribonucleoprotein complex binding / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / lung development / regulation of circadian rhythm / adherens junction / response to lead ion / circadian regulation of gene expression / Circadian Clock / presynapse / perikaryon / dendritic spine / cell division / glutamatergic synapse / nucleolus / extracellular exosome / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 : / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase ...: / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / 4-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-BKM / : / Serine/threonine-protein phosphatase PP1-alpha catalytic subunit類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.208 Å |
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データ登録者 | Choy, M.S. / Peti, W. / Page, R. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) | GM098482 | 米国 | National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) | NS091336 | 米国 | American Diabetes Association | 1-14-A-CN-31 | 米国 |
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引用 | ジャーナル: J. Am. Chem. Soc. / 年: 2017 タイトル: PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. 著者: Choy, M.S. / Swingle, M. / D'Arcy, B. / Abney, K. / Rusin, S.F. / Kettenbach, A.N. / Page, R. / Honkanen, R.E. / Peti, W. |
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履歴 | 登録 | 2017年8月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年11月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年12月13日 | Group: Database references / カテゴリ: citation / Item: _citation.title |
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改定 1.2 | 2017年12月27日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id |
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