登録情報 | データベース: PDB / ID: 5vic |
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タイトル | Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII |
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要素 | - Dengue 1 Envelope DIII domain
- Fab heavy chainFragment antigen-binding
- Fab light chainFragment antigen-binding
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キーワード | IMMUNE SYSTEM (免疫系) / antibody (抗体) / Fab / Zika (ジカ熱) / Dengue (デング熱) / recurrent / neutralizing (中和抗体) |
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機能・相同性 | 機能・相同性情報
immunoglobulin complex / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / フラビビリン / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / double-stranded RNA binding / カプシド / nucleoside-triphosphate phosphatase / protein complex oligomerization ...immunoglobulin complex / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / フラビビリン / host cell mitochondrion / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / double-stranded RNA binding / カプシド / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / 獲得免疫系 / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / protein dimerization activity / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / ヘリカーゼ / symbiont entry into host cell / induction by virus of host autophagy / RNA依存性RNAポリメラーゼ / viral RNA genome replication / virus-mediated perturbation of host defense response / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / host cell nucleus / virion attachment to host cell / virion membrane / structural molecule activity / ATP hydrolysis activity / タンパク質分解 / extracellular space / extracellular region / ATP binding / 生体膜 / metal ion binding / 細胞膜類似検索 - 分子機能 Immunoglobulin-like - #350 / : / Flavivirus capsid protein C superfamily / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus envelope glycoprotein E, stem/anchor domain / Flavivirus non-structural protein NS2B / : / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus ...Immunoglobulin-like - #350 / : / Flavivirus capsid protein C superfamily / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus envelope glycoprotein E, stem/anchor domain / Flavivirus non-structural protein NS2B / : / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M, flavivirus / Flavivirus envelope glycoprotein M / Envelope glycoprotein M superfamily, flavivirus / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / DEAD box, Flavivirus / Flavivirus DEAD domain / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Immunoglobulin subtype / 抗体 / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Helicase superfamily 1/2, ATP-binding domain / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / 抗体 / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Immunoglobulin-like fold / DNA/RNA polymerase superfamily / Immunoglobulin-like / サンドイッチ / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 Immunoglobulin kappa light chain / Genome polyprotein / エンベロープ (ウイルス) / IgG H chain類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Dengue virus type 1 (デング熱ウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3 Å |
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データ登録者 | Keeffe, J.R. / West Jr., A.P. / Gristick, H.B. / Bjorkman, P.J. |
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引用 | ジャーナル: Cell / 年: 2017 タイトル: Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. 著者: Robbiani, D.F. / Bozzacco, L. / Keeffe, J.R. / Khouri, R. / Olsen, P.C. / Gazumyan, A. / Schaefer-Babajew, D. / Avila-Rios, S. / Nogueira, L. / Patel, R. / Azzopardi, S.A. / Uhl, L.F.K. / ...著者: Robbiani, D.F. / Bozzacco, L. / Keeffe, J.R. / Khouri, R. / Olsen, P.C. / Gazumyan, A. / Schaefer-Babajew, D. / Avila-Rios, S. / Nogueira, L. / Patel, R. / Azzopardi, S.A. / Uhl, L.F.K. / Saeed, M. / Sevilla-Reyes, E.E. / Agudelo, M. / Yao, K.H. / Golijanin, J. / Gristick, H.B. / Lee, Y.E. / Hurley, A. / Caskey, M. / Pai, J. / Oliveira, T. / Wunder, E.A. / Sacramento, G. / Nery, N. / Orge, C. / Costa, F. / Reis, M.G. / Thomas, N.M. / Eisenreich, T. / Weinberger, D.M. / de Almeida, A.R.P. / West, A.P. / Rice, C.M. / Bjorkman, P.J. / Reyes-Teran, G. / Ko, A.I. / MacDonald, M.R. / Nussenzweig, M.C. |
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履歴 | 登録 | 2017年4月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年5月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年5月17日 | Group: Database references |
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