登録情報 データベース : PDB / ID : 5qu4 構造の表示 ダウンロードとリンクタイトル Crystal Structure of swapped human Nck SH3.1 domain, 1.05A, orthorhombic form I 要素Cytoplasmic protein NCK1 細胞質 詳細 キーワード SIGNALING PROTEIN / SH3 DOMAIN (SH3ドメイン) / ADAPTOR / PEPTIDE BINDING (ペプチド) / DOMAIN SWAP機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cap-dependent translational initiation / negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation / eukaryotic initiation factor eIF2 binding / positive regulation of peptidyl-serine dephosphorylation / protein phosphatase type 1 complex / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of cap-independent translational initiation / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / cytoskeletal anchor activity / substrate-dependent cell migration, cell extension ... positive regulation of cap-dependent translational initiation / negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation / eukaryotic initiation factor eIF2 binding / positive regulation of peptidyl-serine dephosphorylation / protein phosphatase type 1 complex / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of cap-independent translational initiation / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / cytoskeletal anchor activity / substrate-dependent cell migration, cell extension / vesicle membrane / signal complex assembly / Activation of RAC1 / Nephrin family interactions / DCC mediated attractive signaling / lamellipodium assembly / RHOV GTPase cycle / positive regulation of actin filament polymerization / negative regulation of PERK-mediated unfolded protein response / protein kinase inhibitor activity / antiviral innate immune response / RHOU GTPase cycle / Generation of second messenger molecules / RHO GTPases Activate WASPs and WAVEs / ephrin receptor signaling pathway / signaling adaptor activity / negative regulation of peptidyl-serine phosphorylation / positive regulation of T cell proliferation / regulation of cell migration / T細胞 / negative regulation of insulin receptor signaling pathway / response to endoplasmic reticulum stress / ephrin receptor binding / Downstream signal transduction / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / molecular condensate scaffold activity / actin filament organization / FCGR3A-mediated phagocytosis / PKR-mediated signaling / receptor tyrosine kinase binding / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / positive regulation of neuron projection development / cell-cell junction / signaling receptor complex adaptor activity / 遊走 / protein-macromolecule adaptor activity / Potential therapeutics for SARS / リボソーム / cadherin binding / protein domain specific binding / signaling receptor binding / negative regulation of transcription by RNA polymerase II / 小胞体 / シグナル伝達 / positive regulation of transcription by RNA polymerase II / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Nck1, SH3 domain 1 / Nck1, SH3 domain 2 / Nck1, SH3 domain 3 / Nck1, SH2 domain / Cytoplasmic protein NCK / SH3ドメイン / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン ... Nck1, SH3 domain 1 / Nck1, SH3 domain 2 / Nck1, SH3 domain 3 / Nck1, SH2 domain / Cytoplasmic protein NCK / SH3ドメイン / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3ドメイン 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.05 Å 詳細データ登録者 Rudolph, M.G. 引用ジャーナル : J.Biol.Chem. / 年 : 2020タイトル : Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.著者 : Richter, K. / Rufer, A.C. / Muller, M. / Burger, D. / Casagrande, F. / Grossenbacher, T. / Huber, S. / Hug, M.N. / Koldewey, P. / D'Osualdo, A. / Schlatter, D. / Stoll, T. / Rudolph, M.G. 履歴 登録 2019年12月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年2月12日 Provider : repository / タイプ : Initial release改定 1.1 2021年5月12日 Group : Structure summary / カテゴリ : pdbx_deposit_groupItem : _pdbx_deposit_group.group_description / _pdbx_deposit_group.group_type改定 1.2 2021年6月30日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.3 2024年3月6日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.4 2024年4月3日 Group : Database references / Refinement description / カテゴリ : citation / pdbx_initial_refinement_model / Item : _citation.title
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