登録情報 | データベース: PDB / ID: 5mza |
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タイトル | The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1 |
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要素 | - Erythrocyte membrane protein 1 (PfEMP1)赤血球
- Intercellular adhesion molecule 1
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キーワード | CELL ADHESION (細胞接着) / PfEMP1 ICAM-1 Cerebral malaria |
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機能・相同性 | 機能・相同性情報
modulation by symbiont of host erythrocyte aggregation / infected host cell surface knob / antigenic variation / regulation of leukocyte mediated cytotoxicity / T cell extravasation / positive regulation of cellular extravasation / adhesion of symbiont to microvasculature / regulation of ruffle assembly / T cell antigen processing and presentation / T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ...modulation by symbiont of host erythrocyte aggregation / infected host cell surface knob / antigenic variation / regulation of leukocyte mediated cytotoxicity / T cell extravasation / positive regulation of cellular extravasation / adhesion of symbiont to microvasculature / regulation of ruffle assembly / T cell antigen processing and presentation / T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / membrane to membrane docking / adhesion of symbiont to host / establishment of endothelial barrier / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / cell adhesion mediated by integrin / leukocyte cell-cell adhesion / leukocyte migration / Interleukin-10 signaling / 免疫シナプス / : / Integrin cell surface interactions / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / cell adhesion molecule binding / cellular response to leukemia inhibitory factor / cellular response to glucose stimulus / 細胞接着 / cellular response to amyloid-beta / transmembrane signaling receptor activity / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / integrin binding / virus receptor activity / signaling receptor activity / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / membrane => GO:0016020 / receptor-mediated virion attachment to host cell / positive regulation of ERK1 and ERK2 cascade / DNA-binding transcription factor activity, RNA polymerase II-specific / 細胞接着 / host cell surface receptor binding / 脂質ラフト / external side of plasma membrane / focal adhesion / host cell plasma membrane / 細胞膜 / extracellular space / extracellular exosome / zinc ion binding / 生体膜 / 細胞膜類似検索 - 分子機能 Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment / N-terminal segments of PfEMP1 / Cysteine-rich interdomain region 1 gamma / Cysteine-Rich Interdomain Region 1 gamma / : / ICAM-1/3/5, D2 domain / Intercellular adhesion molecule / Intercellular adhesion molecule, N-terminal / : / Intercellular adhesion molecule (ICAM), N-terminal domain ...Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment / N-terminal segments of PfEMP1 / Cysteine-rich interdomain region 1 gamma / Cysteine-Rich Interdomain Region 1 gamma / : / ICAM-1/3/5, D2 domain / Intercellular adhesion molecule / Intercellular adhesion molecule, N-terminal / : / Intercellular adhesion molecule (ICAM), N-terminal domain / Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal / Duffy-binding-like domain / PFEMP1 DBL domain / Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment / acidic terminal segments, variant surface antigen of PfEMP1 / Zn(2)-C6 fungal-type DNA-binding domain / Duffy-antigen binding / Duffy-antigen binding superfamily / Duffy binding domain / 免疫グロブリンフォールド / Immunoglobulin subtype / 抗体 / Immunoglobulin-like domain superfamily / 抗体 / Immunoglobulin-like fold / Immunoglobulin-like / サンドイッチ / Mainly Beta類似検索 - ドメイン・相同性 TRIPHOSPHATE / フィチン酸 / Intercellular adhesion molecule 1 / Erythrocyte membrane protein 1, PfEMP1類似検索 - 構成要素 |
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生物種 | Plasmodium falciparum 3D7 (マラリア病原虫) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.78 Å |
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データ登録者 | Lennartz, F. / Higgins, M.K. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Wellcome Trust | 101020/Z/13/Z | 英国 |
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引用 | ジャーナル: Cell Host Microbe / 年: 2017 タイトル: Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. 著者: Lennartz, F. / Adams, Y. / Bengtsson, A. / Olsen, R.W. / Turner, L. / Ndam, N.T. / Ecklu-Mensah, G. / Moussiliou, A. / Ofori, M.F. / Gamain, B. / Lusingu, J.P. / Petersen, J.E. / Wang, C.W. / ...著者: Lennartz, F. / Adams, Y. / Bengtsson, A. / Olsen, R.W. / Turner, L. / Ndam, N.T. / Ecklu-Mensah, G. / Moussiliou, A. / Ofori, M.F. / Gamain, B. / Lusingu, J.P. / Petersen, J.E. / Wang, C.W. / Nunes-Silva, S. / Jespersen, J.S. / Lau, C.K. / Theander, T.G. / Lavstsen, T. / Hviid, L. / Higgins, M.K. / Jensen, A.T. |
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履歴 | 登録 | 2017年1月31日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年3月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年10月16日 | Group: Data collection / カテゴリ: reflns_shell |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[1][2] / _atom_site_anisotrop.U[1][3] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[2][3] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_auth_comp_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _atom_site_anisotrop.pdbx_label_atom_id / _atom_site_anisotrop.pdbx_label_comp_id / _atom_site_anisotrop.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2020年10月7日 | Group: Structure summary / カテゴリ: chem_comp / Item: _chem_comp.pdbx_synonyms |
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