登録情報 データベース : PDB / ID : 5axi 構造の表示 ダウンロードとリンクタイトル Crystal structure of Cbl-b TKB domain in complex with Cblin 要素Cblin E3 ubiquitin-protein ligase CBL-B 詳細キーワード LIGASE/LIGASE inhibitor / Ubquitin ligase / phosphopeptide / cblin / LIGASE-LIGASE inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
peptidyl-amino acid modification / IRS-mediated signalling / Signaling by ALK / IRS-related events triggered by IGF1R / SOS-mediated signalling / negative regulation of alpha-beta T cell proliferation / PI3K/AKT activation / PI3K Cascade / negative regulation of somatostatin secretion / positive regulation of glucagon secretion ... peptidyl-amino acid modification / IRS-mediated signalling / Signaling by ALK / IRS-related events triggered by IGF1R / SOS-mediated signalling / negative regulation of alpha-beta T cell proliferation / PI3K/AKT activation / PI3K Cascade / negative regulation of somatostatin secretion / positive regulation of glucagon secretion / IRS activation / Interleukin-7 signaling / regulation of T cell receptor signaling pathway / negative regulation of epidermal growth factor-activated receptor activity / Signal attenuation / epithelial cell migration / regulation of platelet-derived growth factor receptor-alpha signaling pathway / RAF/MAP kinase cascade / positive regulation of T cell anergy / PIP3 activates AKT signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / phosphatidylinositol 3-kinase activator activity / regulation of protein binding / Antigen processing: Ubiquitination & Proteasome degradation / mammary gland development / insulin receptor complex / transmembrane receptor protein tyrosine kinase adaptor activity / response to caffeine / positive regulation of mesenchymal cell proliferation / cellular response to fatty acid / negative regulation of T cell receptor signaling pathway / regulation of GTPase activity / positive regulation of epithelial cell migration / protein localization to nucleus / negative regulation of insulin secretion / regulation of cell adhesion / phosphatidylinositol 3-kinase binding / lipid catabolic process / positive regulation of insulin receptor signaling pathway / positive regulation of phosphorylation / insulin-like growth factor receptor binding / T細胞 / negative regulation of insulin receptor signaling pathway / phosphotyrosine residue binding / SH2 domain binding / insulin-like growth factor receptor signaling pathway / ciliary basal body / positive regulation of protein ubiquitination / protein kinase C binding / RING-type E3 ubiquitin transferase / insulin receptor binding / receptor tyrosine kinase binding / SH3 domain binding / cellular response to insulin stimulus / positive regulation of protein catabolic process / ubiquitin protein ligase activity / 遊走 / insulin receptor signaling pathway / protein-macromolecule adaptor activity / T cell receptor signaling pathway / 遺伝子発現の調節 / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / intracellular signal transduction / 免疫応答 / 脂質ラフト / protein domain specific binding / calcium ion binding / protein-containing complex binding / protein kinase binding / シグナル伝達 / 核質 / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 インスリン受容体基質 / E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass / Phosphotyrosine-binding domain (IRS1-like) / IRS-type PTB domain profile. / IRS-type PTB domain / PTB domain (IRS-1 type) / Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain ... インスリン受容体基質 / E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass / Phosphotyrosine-binding domain (IRS1-like) / IRS-type PTB domain profile. / IRS-type PTB domain / PTB domain (IRS-1 type) / Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl / CBL proto-oncogene N-terminal domain 1 / CBL proto-oncogene N-terminus, EF hand-like domain / CBL proto-oncogene N-terminus, SH2-like domain / Cbl-type phosphotyrosine-binding (Cbl-PTB) domain profile. / Phosphotyrosine-binding domain / Adaptor protein Cbl, N-terminal domain superfamily / Transcription Elongation Factor S-II; Chain A / Ubiquitin associated domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / SH2ドメイン / SHC Adaptor Protein / EFハンド / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Recoverin; domain 1 / PH domain / 薬指 / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Zinc finger RING-type profile. / Zinc finger, RING-type / SH2 domain superfamily / EF-hand domain pair / PH-like domain superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Insulin receptor substrate 1 / E3 ubiquitin-protein ligase CBL-B 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Ohno, A. / Maita, N. / Ochi, A. / Nakao, R. / Nikawa, T. 引用ジャーナル : Arch.Biochem.Biophys. / 年 : 2016タイトル : Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin著者 : Ohno, A. / Ochi, A. / Maita, N. / Ueji, T. / Bando, A. / Nakao, R. / Hirasaka, K. / Abe, T. / Teshima-Kondo, S. / Nemoto, H. / Okumura, Y. / Higashibata, A. / Yano, S. / Tochio, H. / Nikawa, T. 履歴 登録 2015年7月29日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2016年3月2日 Provider : repository / タイプ : Initial release改定 1.1 2016年3月9日 Group : Database references改定 1.2 2020年2月26日 Group : Data collection / Database references / Derived calculationsカテゴリ : citation / diffrn_source / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation改定 1.3 2023年11月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id 改定 1.4 2023年11月15日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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