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- PDB-4u2x: Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus -

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Open data

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Basic information

Entry

Database: PDB / ID: 4u2x

Title

Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus

Components

Importin subunit alpha-6
Membrane-associated protein VP24

Keywords

VIRAL PROTEIN / eVP24 / importin alpha6 / immune antagonist

Function / homology

Function and homology information

suppression by virus of host intracellular interferon activity / host cell endomembrane system / modulation by virus of host cellular process / NS1 Mediated Effects on Host Pathways / nuclear import signal receptor activity /

nuclear localization sequence binding / NLS-bearing protein import into nucleus / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity /

viral budding from plasma membrane / ISG15 antiviral mechanism ...
Similarity search - Function

Biological species

Zaire ebolavirus

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON / Resolution: 3.153 Å

Authors

Xu, W. / Leung, D. / Borek, D. / Amarasinghe, G.

Funding support

United States, 2items

Organization	Grant number	Country
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	R01AI107056	United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	R01AI081914	United States

Citation

Journal: Cell Host Microbe / Year: 2014
Title: Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Authors: Xu, W. / Edwards, M.R. / Borek, D.M. / Feagins, A.R. / Mittal, A. / Alinger, J.B. / Berry, K.N. / Yen, B. / Hamilton, J. / Brett, T.J. / Pappu, R.V. / Leung, D.W. / Basler, C.F. / Amarasinghe, G.K.

History

Deposition	Jul 18, 2014	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Aug 13, 2014	Provider: repository / Type: Initial release
Revision 1.1	Aug 27, 2014	Group: Database references
Revision 1.2	Sep 6, 2017	Group: Author supporting evidence / Derived calculations ...Author supporting evidence / Derived calculations / Other / Source and taxonomy / Structure summary Category: entity_src_gen / pdbx_audit_support ...entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list / struct_keywords Item: _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization ..._entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.type / _pdbx_struct_assembly_prop.value / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text
Revision 1.3	Nov 1, 2017	Group: Author supporting evidence / Category: pdbx_struct_assembly_auth_evidence
Revision 1.4	Dec 11, 2019	Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.5	Dec 27, 2023	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine_hist / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.d_res_high / _refine_hist.number_atoms_total / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewer	Molecule: MolmilJmol/JSmol

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Downloads & links

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Download

PDBx/mmCIF format	4u2x.cif.gz	483.2 KB	Display	PDBx/mmCIF format
PDB format	pdb4u2x.ent.gz	405.6 KB	Display	PDB format
PDBx/mmJSON format	4u2x.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/u2/4u2x ftp://data.pdbj.org/pub/pdb/validation_reports/u2/4u2x	HTTPS FTP

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Related structure data

Similar structure data	3m6w-d 5rya-d 3m6u-1 3u07-1 5rxp-d 5rw9-d 4tl3-d 1dk8-1 6cww-d 4oo0-d Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#178 - Oct 2014 Ebola Virus Proteins similarity (2) #85 - Jan 2007 Importins similarity (12) #205 - Jan 2017 Nuclear Pore Complex similarity (3) #99 - Mar 2008 Cadherin similarity (4) #88 - Apr 2007 Clathrin similarity (2)

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Assembly

Deposited unit

A: Membrane-associated protein VP24

B: Membrane-associated protein VP24

C: Membrane-associated protein VP24

D: Importin subunit alpha-6

E: Importin subunit alpha-6

F: Importin subunit alpha-6

hetero molecules

132 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

A: Membrane-associated protein VP24

D: Importin subunit alpha-6

hetero molecules

defined by author&software
Evidence: light scattering
43.9 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

B: Membrane-associated protein VP24

E: Importin subunit alpha-6

hetero molecules

defined by author&software
Evidence: light scattering
43.9 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

C: Membrane-associated protein VP24

F: Importin subunit alpha-6

defined by author&software
Evidence: light scattering
43.9 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	103.925, 103.925, 333.630
Angle α, β, γ (deg.)	90.000, 90.000, 120.000
Int Tables number	152
Space group name H-M	P3₁21

Components on special symmetry positions

ID	Model	Components
1	1	A-301- CL

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
1	1	A
2	1	B
1	2	A
2	2	C
1	3	B
2	3	C
1	4	D
2	4	E
1	5	D
2	5	F
1	6	E
2	6	F

NCS domain segments:

Component-ID: 0 / Refine code: 0

Dom-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	ASP	ASP	ALA	ALA	A	A	16 - 229	1 - 214
2	1	ASP	ASP	ALA	ALA	B	B	16 - 229	1 - 214
1	2	ASP	ASP	THR	THR	A	A	16 - 231	1 - 216
2	2	ASP	ASP	THR	THR	C	C	16 - 231	1 - 216
1	3	ASP	ASP	PHE	PHE	B	B	16 - 230	1 - 215
2	3	ASP	ASP	PHE	PHE	C	C	16 - 230	1 - 215
1	4	ILE	ILE	GLY	GLY	D	D	335 - 506	4 - 175
2	4	ILE	ILE	GLY	GLY	E	E	335 - 506	4 - 175
1	5	ILE	ILE	PHE	PHE	D	D	335 - 505	4 - 174
2	5	ILE	ILE	PHE	PHE	F	F	335 - 505	4 - 174
1	6	VAL	VAL	PHE	PHE	E	E	334 - 505	3 - 174
2	6	VAL	VAL	PHE	PHE	F	F	334 - 505	3 - 174

NCS ensembles :

ID
1
2
3
4
5
6

Details

Biological assembly confirmed by multiangle light scattering

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Components

#1: Protein	Membrane-associated protein VP24 Mass: 24421.334 Da / Num. of mol.: 3 / Fragment: eVP24 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Zaire ebolavirus / Strain: Mayinga-76 / Gene: VP24 / Plasmid: modified pET15b / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: Q05322
#2: Protein	Importin subunit alpha-6 / / Karyopherin subunit alpha-5 Mass: 19477.389 Da / Num. of mol.: 3 / Fragment: KPNA5 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: KPNA5 / Plasmid: modified pET15b / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: O15131
#3: Chemical	ChemComp-CL / CHLORIDE ION / Chloride Mass: 35.453 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Cl
#4: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 24 / Source method: isolated from a natural source / Formula: H₂O

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Experimental details

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.95 Å³/Da / Density % sol: 68.85 %
Crystal grow	Temperature: 298 K / Method: vapor diffusion, hanging drop / pH: 7 / Details: 3.5M ammonium chloride, 0.1 M Bis-Tris propane

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Data collection

Diffraction

Mean temperature: 100 K

Diffraction source

Source:

SYNCHROTRON / Site:

APS

/ Beamline: 19-ID / Wavelength: 0.9792601 Å

Detector

Type: ADSC QUANTUM 315 / Detector: CCD / Date: Feb 17, 2014

Radiation

Monochromator: Rosenbaum-Rock high-resolution double-crystal monochromator
Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 0.9792601 Å / Relative weight: 1

Reflection

Resolution: 3.15→50 Å / Num. obs: 35719 / % possible obs: 96.2 % / Redundancy: 6 % / R_merge(I) obs: 0.091 / Χ²: 0.894 / Net I/av σ(I): 14.839 / Net I/σ(I): 8.1 / Num. measured all: 214292

Reflection shell

Diffraction-ID: 1 / Rejects: 0

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Num. unique all	Χ²	% possible all
3.15-3.2	6	0.953	1735	0.7	98.1
3.2-3.26	6	0.83	1791	0.72	97.2
3.26-3.33	6	0.653	1794	0.72	98.1
3.33-3.39	6	0.576	1762	0.728	97.4
3.39-3.47	5.9	0.469	1788	0.793	97
3.47-3.55	6.1	0.36	1764	0.784	98.3
3.55-3.64	6	0.296	1791	0.819	97.4
3.64-3.73	5.9	0.234	1786	0.902	97.3
3.73-3.84	6	0.188	1794	0.901	97.1
3.84-3.97	6.1	0.165	1774	0.974	97.1
3.97-4.11	6.1	0.132	1787	1.019	96.5
4.11-4.27	6	0.109	1776	1.053	96.8
4.27-4.47	6	0.092	1792	1.072	96.9
4.47-4.7	6	0.09	1790	1.124	96.2
4.7-5	6.1	0.085	1779	1.222	95.3
5-5.38	6	0.075	1789	1.11	96.1
5.38-5.93	6	0.073	1791	0.983	95.6
5.93-6.78	5.9	0.055	1773	0.835	93.4
6.78-8.54	6	0.041	1817	0.788	93.4
8.54-50	5.8	0.032	1846	0.626	89.5

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Processing

Software

Name	Version	Classification
HKL-3000		data reduction
REFMAC	5.7.0029	refinement
PDB_EXTRACT	3.14	data extraction

Refinement

Resolution: 3.153→35.12 Å / Cor.coef. F_o:F_c: 0.92 / Cor.coef. F_o:F_c free: 0.889 / SU B: 38.444 / SU ML: 0.308 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 0.476 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.2492	1555	5 %	RANDOM
R_work	0.2146	29294	-	-
obs	0.2163	30849	83.19 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK

Displacement parameters

B_iso max: 217.56 Å² / B_iso mean: 78.725 Å² / B_iso min: 7.61 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	0.04 Å²	0.04 Å²	-0 Å²
2-	-	0.04 Å²	-0 Å²
3-	-	-	-0.14 Å²

Refinement step

Cycle: final / Resolution: 3.153→35.12 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	9163	0	2	24	9189
B_iso mean	-	-	71.82	28.91	-
Num. residues	-	-	-	-	1162

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.004	0.019	9347
X-RAY DIFFRACTION	r_bond_other_d	0.002	0.02	9231
X-RAY DIFFRACTION	r_angle_refined_deg	0.824	1.961	12673
X-RAY DIFFRACTION	r_angle_other_deg	0.745	3	21197
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	4.318	5	1156
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	30.37	25.061	407
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	13.505	15	1692
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	12.455	15	42
X-RAY DIFFRACTION	r_chiral_restr	0.046	0.2	1485
X-RAY DIFFRACTION	r_gen_planes_refined	0.003	0.02	10479
X-RAY DIFFRACTION	r_gen_planes_other	0.001	0.02	2109

Refine LS restraints NCS

Refine-ID: X-RAY DIFFRACTION / Type: interatomic distance / Weight position: 0.05

Ens-ID	Dom-ID	Auth asym-ID	Number	Rms dev position (Å)
1	1	A	13564	0.05
1	2	B	13564	0.05
2	1	A	13379	0.07
2	2	C	13379	0.07
3	1	B	13356	0.07
3	2	C	13356	0.07
4	1	D	10384	0.08
4	2	E	10384	0.08
5	1	D	10508	0.07
5	2	F	10508	0.07
6	1	E	10577	0.08
6	2	F	10577	0.08

LS refinement shell

Resolution: 3.153→3.234 Å / Total num. of bins used: 20

	R_factor	Num. reflection	% reflection
R_free	0.297	63	-
R_work	0.275	925	-
all	-	988	-
obs	-	-	37.18 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	7.0452	-10.5208	2.1353	31.3168	-1.6491	6.6755	0.4334	-0.2232	0.1388	-0.2048	-0.2994	0.0936	0.0113	-0.4973	-0.134	0.1833	0.0028	0.0476	0.3518	0.008	0.2742	-18.2913	5.0279	-52.1522
2	5.5309	-6.0188	-1.9428	15.3203	4.3094	2.0688	0.0225	0.3235	-0.0564	0.0086	0.2662	-0.2334	0.3586	-0.2883	-0.2887	0.2219	-0.0859	-0.0804	0.2579	0.0035	0.3241	-9.44	-13.8318	-54.2943
3	2.7196	-4.1617	1.9361	9.0277	-4.0522	2.0895	0.0693	0.0873	-0.1473	-0.0584	0.0061	-0.039	0.1132	0.1182	-0.0754	0.183	0.0062	-0.0476	0.2231	-0.0734	0.398	-1.5144	-19.5497	-48.1825
4	20.725	1.4079	8.5895	6.5391	0.2029	3.6436	0.1807	-0.9193	-0.2445	-0.8906	-0.2144	0.5149	0.0958	-0.2637	0.0338	0.1505	0.0265	-0.1717	0.4115	0.1095	0.5025	10.987	-35.0664	-40.1674
5	10.9631	-3.9401	3.5124	3.2795	2.6362	9.3801	-0.3312	-0.2993	0.3066	0.2791	0.2391	-0.2284	0.0439	0.0195	0.092	0.2559	0.0507	-0.1651	0.3112	-0.0069	0.4266	7.5693	-25.4184	-34.2444
6	1.01	-0.8118	0.8012	0.7906	-0.0174	3.7927	0.0353	-0.5402	0.0704	-0.0907	0.4256	-0.1669	0.034	-0.3632	-0.461	0.1941	-0.0022	-0.0495	0.3434	-0.0272	0.4048	-4.2691	-15.966	-38.9646
7	23.2137	-0.6022	-22.795	26.953	-1.3805	22.5321	0.0995	-2.2697	0.8886	2.3352	0.6745	-0.6017	-0.2537	2.2104	-0.7741	0.5284	0.0624	-0.3355	0.5521	-0.1166	0.5241	-2.8579	3.8899	-34.3268
8	14.8076	-18.2193	18.3474	22.42	-22.5752	22.7351	-1.0357	-0.5084	0.2505	1.3219	0.6857	-0.3023	-1.3352	-0.6354	0.35	0.7156	-0.0695	0.1925	0.6724	-0.2396	0.5279	-12.1352	8.048	-33.8842
9	2.7424	0.8673	1.2288	1.5756	1.8803	2.5596	-0.0743	-0.2558	-0.0984	-0.1248	0.33	-0.1983	-0.1476	-0.0578	-0.2557	0.3312	-0.006	-0.0067	0.5386	0.0275	0.3549	-14.8417	-6.97	-40.7772
10	0.0248	0.2092	-0.6573	1.9118	-5.9316	18.449	0.0165	-0.0299	0.0111	0.0467	-0.043	-0.0404	-0.138	0.275	0.0265	0.2493	0.0863	0.0089	0.6065	-0.0302	0.5155	-22.7962	2.8458	-39.1489
11	7.9128	-8.4951	-3.4611	11.6638	7.1836	6.2966	-0.2498	-0.4823	0.4206	0.3001	0.483	-0.5386	-0.0482	-0.0461	-0.2332	0.4332	0.1652	0.0175	0.3686	0.009	0.2792	-9.5087	5.9475	-45.9182
12	3.3366	-6.1404	3.0289	11.4756	-5.6015	2.824	-0.1455	-0.1314	0.5942	-0.1278	-0.0715	-1.018	-0.0887	-0.066	0.217	0.3555	0.0764	0.1258	0.2939	-0.1118	0.6728	4.825	-3.4824	-44.0133
13	34.2344	5.777	-14.4506	0.9751	-2.4386	6.1012	0.5299	-1.1541	0.6768	0.0889	-0.2081	0.1116	-0.2066	0.5003	-0.3219	0.4596	-0.0247	-0.5005	0.6512	-0.0496	0.7762	17.5961	-13.5664	-37.2076
14	26.61	-0.6325	-18.1339	2.1506	-0.7455	13.0748	0.2679	0.3813	0.4452	0.2187	0.0816	-0.1801	-0.3109	-0.37	-0.3495	0.2011	0.0112	-0.0911	0.3628	-0.0578	0.3309	-1.7101	-9.0939	-31.0075
15	8.4497	-1.6155	2.8418	4.3845	5.6059	10.2376	-0.5221	0.1633	-0.0039	0.3905	0.3495	0.0691	0.2313	0.5775	0.1726	0.2744	0.0208	-0.0636	0.1768	-0.0604	0.4233	6.0701	-15.3171	-39.9131
16	3.2415	0.5976	-5.1989	1.3882	3.6092	26.086	0.2675	0.0231	0.0076	0.4158	0.064	-0.2317	0.8298	-0.5433	-0.3315	0.4136	0.1384	-0.1321	0.4784	-0.0989	0.3385	-1.6327	-16.1535	-32.3906
17	11.9667	-15.1248	3.2189	23.2213	-4.3596	0.8873	-0.7628	-0.8989	-0.414	0.8038	0.9283	0.834	-0.1792	-0.2176	-0.1655	0.3014	0.121	-0.1075	0.4128	0.0121	0.2242	1.4768	-21.2233	-22.8045
18	1.8361	-0.1399	-0.7132	3.384	-0.7815	0.489	-0.1994	0.041	-0.385	0.2884	0.1892	0.3058	-0.0111	-0.1002	0.0102	0.3008	0.164	0.0146	0.3209	0.0862	0.5765	-3.2916	-22.8934	-30.6822
19	15.8238	-8.3229	-10.3082	14.0008	-5.6067	19.3581	0.9075	0.3424	0.3919	-0.1785	-0.46	-0.0226	-0.8619	0.1713	-0.4475	0.2475	-0.0136	-0.0041	0.3491	-0.1729	0.343	3.9516	-15.9791	-49.1608
20	44.3065	24.0313	-8.7278	20.1304	0.7078	5.8967	0.2278	-0.2348	-1.5421	0.4811	0.0696	-1.6412	0.1917	0.2353	-0.2974	0.2924	-0.0159	-0.1708	0.4631	0.0155	0.6638	5.8879	-7.5778	-52.4167
21	9.6265	0.5451	0.0802	3.7467	-9.6693	25.2442	0.3969	-0.1487	0.1204	-0.4335	-0.2165	0.0567	1.0853	0.6366	-0.1804	0.3452	0.0016	-0.0006	0.3793	-0.1271	0.2927	57.5065	-45.5156	-11.7921
22	1.6217	-1.9524	1.2297	3.1541	-0.6698	1.7872	-0.0169	-0.2174	-0.0835	0.2883	0.3499	-0.0623	0.2244	0.0018	-0.333	0.344	-0.019	0.0188	0.3563	-0.0847	0.3713	37.6357	-44.1321	-10.6437
23	15.7108	-2.4203	5.4852	1.4258	0.775	4.4889	-0.2445	-0.814	-0.2678	0.1503	-0.0015	0.1424	-0.0084	-0.568	0.246	0.3083	0.0655	-0.0338	0.3335	-0.087	0.3867	34.4895	-38.1571	-10.1062
24	2.5229	-1.3415	7.1202	10.2807	2.1355	24.3606	-0.346	-0.4176	0.0392	0.5857	-0.0657	0.4165	0.0193	-0.9607	0.4117	0.4703	0.2468	0.1078	0.4824	0.15	0.3426	16.8017	-37.9207	-18.307
25	0.182	-1.2626	-1.4936	9.1279	11.0299	13.5315	0.1277	0.1573	-0.2052	-0.7719	-1.1511	1.0484	-0.7562	-1.482	1.0234	0.3568	0.1353	-0.1178	0.6332	0.0522	0.692	8.4999	-34.6951	-24.359
26	15.7509	9.0966	-9.6651	10.9731	-16.2278	25.7653	-0.303	0.5652	1.0525	0.6718	0.6018	0.4613	-1.3964	-0.7694	-0.2988	0.4623	0.2287	-0.0302	0.5234	0.1072	0.5832	14.7496	-28.7851	-27.4175
27	3.1919	-0.6561	3.3946	0.3752	-0.9957	4.0571	0.1919	-0.0095	-0.3288	0.1769	0.1858	0.1898	-0.1389	-0.1129	-0.3777	0.3024	0.0894	-0.0036	0.2595	0.0762	0.4216	24.4666	-39.0515	-26.4826
28	12.0766	-1.7598	6.6973	2.0479	-0.1919	4.0612	0.0812	0.8984	-0.0499	-0.1314	-0.1094	0.1198	-0.062	0.5137	0.0283	0.4287	-0.1475	0.0836	0.467	-0.05	0.3646	42.5121	-33.1248	-24.7898
29	20.4354	1.93	4.2524	32.8234	-2.867	1.2128	0.1953	0.1686	1.3048	-0.8861	-0.5718	-1.0277	0.1493	0.0996	0.3766	0.7828	0.2151	0.0816	0.4664	-0.0713	0.3544	53.5593	-33.9479	-30.2682
30	4.6062	0.4156	-0.2131	5.6922	-1.889	3.0528	-0.0407	-0.2169	0.4166	0.2972	0.2484	0.0347	0.0973	-0.1171	-0.2077	0.2242	-0.0118	-0.0431	0.2445	-0.0696	0.3286	42.7421	-45.6328	-23.5754
31	22.7607	11.0254	-2.8525	6.9882	3.9051	17.3486	0.0262	-1.0037	-0.6686	-0.1323	-0.2982	-0.3044	-0.5243	0.692	0.2721	0.2751	0.1206	-0.2195	0.3902	-0.1213	0.6988	53.723	-49.9393	-26.7198
32	3.4814	-1.4052	-3.1155	14.5059	19.274	26.0781	0.5992	0.6476	0.16	0.634	0.0539	-0.4998	0.5825	-0.1977	-0.6532	0.3612	0.1312	-0.2301	0.7415	0.0557	0.2813	56.9652	-43.2073	-20.2387
33	15.156	-6.1214	7.6447	2.4876	-3.0695	3.9292	0.1627	0.054	0.4347	-0.0842	-0.144	-0.2097	0.0793	0.0128	-0.0188	0.2747	-0.0228	0.0167	0.3858	-0.0409	0.5065	46.9889	-31.9753	-17.4581
34	34.0202	-16.6897	1.6932	17.9856	-2.7928	0.4791	-0.5278	-0.7859	1.0796	-0.0013	0.4984	-0.3354	-0.0075	-0.0684	0.0295	0.6213	0.1712	-0.0898	0.2235	-0.1115	0.3263	33.7997	-22.7527	-19.1078
35	5.5391	-6.7473	1.725	49.8258	29.6381	24.7652	-3.3124	-1.6671	0.7042	1.2258	1.6837	0.842	-3.2619	-0.9525	1.6287	2.5953	1.1344	-0.105	1.3246	-0.0636	0.8176	22.0958	-17.9279	-25.3702
36	4.3859	-2.5441	-5.0289	6.077	6.5498	8.736	0.029	0.3961	0.3938	-0.0946	0.2097	-0.201	-0.1977	-0.1715	-0.2387	0.3036	0.1666	-0.0555	0.1788	0.0481	0.4456	32.6838	-29.781	-28.8228
37	3.3264	1.3919	0.4366	3.1284	5.1971	9.9711	-0.003	-0.0098	0.0549	-0.3514	0.1097	-0.0338	-0.7954	0.1161	-0.1067	0.4575	0.1607	0.0461	0.2434	0.0815	0.3258	25.7787	-31.8613	-22.5634
38	7.2278	-2.9561	0.2962	1.5116	0.0573	0.1198	-0.0273	0.2058	0.2217	-0.2452	-0.0726	0.051	-0.1331	0.0028	0.1	0.4042	-0.042	-0.0981	0.3905	0.1832	0.4054	24.8535	-36.4826	-39.3502
39	2.3963	-1.4322	0.8881	1.4132	-2.628	8.393	-0.145	-0.322	-0.2097	0.2191	0.3291	0.1387	-0.3328	-0.2097	-0.1841	0.319	0.2042	0.0517	0.3579	0.0094	0.3305	26.1909	-35.1321	-18.9853
40	63.8627	27.0871	20.1402	13.5438	5.332	11.3832	-0.4219	0.5835	0.7976	0.7796	0.9963	0.8479	-1.622	-0.9015	-0.5745	0.6674	0.3343	0.1601	0.5453	0.0248	0.2704	33.7965	-29.3837	-10.5485
41	7.5439	8.5625	-3.8817	33.6387	-9.9315	10.2696	-0.2472	-0.004	-0.2244	-0.6474	0.6959	0.1379	0.2059	-0.8399	-0.4487	0.1405	0.0491	-0.066	0.4165	0.0537	0.2844	-13.8969	-74.6586	5.2062
42	2.1774	-0.0139	-0.6003	0.4182	-1.1279	3.23	0.0044	-0.1455	0.0516	0.0922	0.1612	0.075	-0.2364	-0.2739	-0.1656	0.3808	0.1434	0.0209	0.3589	0.0777	0.3403	-8.1771	-56.0453	6.8945
43	1.3594	-1.1847	-1.3453	15.6865	-5.8002	4.6503	0.1451	-0.3258	0.0318	0.8315	-0.1339	-0.1095	-0.5995	0.5334	-0.0111	0.3695	-0.0907	-0.0878	0.3619	-0.0369	0.3197	-1.9205	-52.6585	3.9754
44	3.1127	-1.2799	3.5918	27.9406	-23.3004	21.518	-0.4452	-0.4359	1.4228	1.137	-0.3292	0.5718	-1.3375	-0.0508	0.7744	0.7309	0.0727	-0.0202	0.2645	-0.1815	0.7528	-2.1818	-36.8167	-6.8221
45	9.888	2.4949	5.6436	1.6484	-3.1233	23.5266	-1.3259	0.9491	2.2752	-0.478	0.0101	0.5779	-0.0542	1.4862	1.3158	0.7736	-0.0548	-0.0192	0.4949	0.1257	0.6995	6.0188	-35.2698	-9.9956
46	34.54	14.0233	-10.1749	9.7797	-13.2036	23.3162	-0.3419	-0.5562	0.9605	-0.1776	-0.7718	-0.3114	0.155	1.1104	1.1137	0.4165	0.109	0.0476	0.5068	0.1753	0.4786	3.1002	-42.2073	-16.9651
47	0.9344	0.394	-0.6663	3.4329	-1.5825	1.0317	0.0525	0.0611	0.0199	-0.0975	-0.0485	-0.1137	-0.1136	-0.1104	-0.0041	0.4568	0.1626	0.0006	0.3584	0.095	0.2837	-6.0834	-49.881	-8.9778
48	35.5802	13.3336	-6.9904	8.9798	-3.555	1.5962	-0.6529	1.7788	-1.6185	-1.79	0.5448	0.2578	0.4764	-0.2834	0.1081	0.8768	0.0141	-0.1682	0.6621	-0.1693	0.3376	-1.9384	-68.9919	-13.6186
49	1.4878	-1.0483	-0.9655	2.9489	-3.3094	7.8303	-0.0495	-0.2248	-0.1673	-0.2583	0.0295	0.1844	0.5651	0.395	0.02	0.2312	-0.0172	-0.0296	0.3975	0.0324	0.3882	-11.3404	-70.1194	-10.3967
50	10.9515	2.3777	-0.3859	5.3756	-2.053	0.8339	-0.1315	-0.6197	-0.0928	0.1491	0.2107	0.0231	-0.1447	-0.2056	-0.0792	0.3856	0.1883	0.0072	0.4282	0.14	0.3169	-17.1945	-60.8348	-3.1679
51	13.0667	-5.7895	3.7244	4.7545	-7.6157	17.3284	-1.0149	0.5098	-0.2856	0.4821	0.0868	-0.1964	-0.2357	-0.3174	0.9281	0.4145	-0.1049	-0.1456	0.2879	0.0319	0.5097	-18.9039	-75.2935	-5.9027
52	8.7153	6.347	-2.7257	14.5961	8.5753	12.0346	-0.3595	0.514	-0.4418	-0.0774	0.3553	-0.4626	0.2994	-0.1846	0.0042	0.2596	-0.0007	-0.0717	0.3865	0.0869	0.3197	-4.3627	-74.0247	-0.9934
53	15.8783	7.7745	-1.5564	14.0828	-4.6087	1.5975	-0.0077	0.3218	-0.664	-0.0263	-0.2541	-0.8236	-0.0303	0.1077	0.2618	0.3522	0.0238	-0.0077	0.3493	0.0415	0.268	6.4652	-62.0728	-5.9727
54	70.0433	9.7697	-36.1758	2.8152	-4.3603	19.0218	-0.1893	-0.3483	-1.5426	-0.5189	-0.9888	0.5828	-0.2356	-0.187	1.1781	0.7276	-0.1051	-0.4199	0.9839	-0.2365	0.7731	15.1107	-47.7639	-14.6299
55	5.5187	2.0656	1.5955	1.1751	-0.0285	3.9162	0.0858	-0.0252	-0.2221	-0.1856	-0.0592	-0.2473	-0.3383	-0.0093	-0.0266	0.3711	0.0348	0.0407	0.2722	0.0378	0.2991	2.2302	-54.2287	-13.1042
56	15.7693	-4.9241	-8.9441	18.1392	8.4988	7.0352	0.3825	0.5268	0.4796	-1.3188	-0.1637	0.0539	-0.616	-0.3155	-0.2188	0.5776	-0.0999	-0.1125	0.3444	0.2078	0.3328	-6.4699	-52.2745	-18.0638
57	39.6595	-7.4186	-7.5126	41.4033	4.4386	1.6532	-0.0334	0.4768	0.4666	-0.5987	0.102	0.2629	-0.044	-0.074	-0.0686	0.4623	-0.0474	0.0496	0.4399	0.0506	0.1216	-4.769	-48.8995	-24.3067
58	1.8858	4.2024	-2.8343	12.82	-10.9251	12.7444	-0.2888	-0.0109	0.3263	-0.0674	0.2821	0.188	-0.0698	-0.1137	0.0068	0.6139	0.1596	-0.054	0.3301	0.1212	0.3135	-6.5411	-43.8847	-19.7288
59	4.362	1.3992	5.078	10.8347	-2.5466	30.0132	-0.245	-0.2075	-0.2522	-0.0872	-0.0763	-0.279	-0.1524	0.347	0.3213	0.3589	0.0088	-0.0267	0.2105	-0.0256	0.3252	3.5421	-50.0306	-0.5403
60	0.7172	-0.4437	2.0431	0.2766	-1.2788	9.1556	0.1729	-0.5277	0.6055	-0.1296	0.313	-0.3703	-0.4396	-0.9076	-0.4859	1.012	-0.3004	0.6377	0.7543	-0.6647	2.1188	6.582	-58.0534	2.7363
61	0.4857	0.3258	-3.0074	0.2247	-2.0477	18.8896	0.1808	-0.1254	0.0039	0.0813	-0.0176	0.0489	-0.6459	0.5821	-0.1632	0.6255	-0.1655	-0.0888	0.7919	0.0946	0.6579	-15.0472	-15.3511	2.9937
62	22.7096	28.7935	7.804	37.8765	15.0652	22.8027	1.3272	0.5012	-0.4643	1.7362	0.5905	-0.9801	-0.7915	0.7609	-1.9177	1.0713	0.0654	0.1505	0.6506	-0.0844	0.1445	-11.9486	-7.8473	-1.771
63	1.8632	5.959	-1.4082	45.9054	-16.1562	6.1222	-0.4256	-0.4178	-0.0464	0.2346	-0.4603	-2.1352	-0.3601	-0.083	0.8859	0.7155	0.0105	0.0034	0.7587	0.0401	0.1955	-4.7594	-10.0621	-7.6495
64	14.3733	-9.4722	-12.744	30.4198	3.7399	12.1994	-0.3922	-0.5341	-0.628	1.3277	-0.2187	0.0962	0.115	0.5456	0.6109	0.82	0.0466	0.0821	0.812	0.1094	0.0466	-13.4158	-16.379	-8.3083
65	44.448	-29.3388	-7.6384	29.2826	-1.0646	5.0911	-0.9648	0.0109	-1.2195	1.3352	0.4459	0.2301	-0.1965	-0.3714	0.5189	0.6424	-0.0762	-0.0483	0.611	0.2199	0.1725	-26.3646	-15.6848	-7.2136
66	4.3722	2.2111	-7.3981	3.2587	-8.5711	23.4226	0.3072	-0.2057	-0.6571	-0.1872	-0.0373	0.2984	0.3065	0.2467	-0.2698	0.4572	0.1067	0.1446	0.6709	0.0411	0.522	-27.3783	-10.0774	-3.9838
67	0.0333	0.552	-0.3941	16.4099	-12.8929	10.2456	0.1342	0.0875	0.0212	0.3497	-0.3697	-0.1935	-0.03	0.6403	0.2355	0.8518	0.5597	0.0875	1.1492	0.0127	0.3125	-21.8466	-3.9136	-5.7187
68	4.2996	-2.8214	8.5076	4.2925	-10.509	26.7847	0.1365	-0.7859	0.5319	0.611	-0.3623	0.0556	-1.2013	0.1892	0.2258	0.6328	-0.0311	0.0925	0.6253	-0.2061	0.2982	-13.5927	-4.0314	-15.1539
69	9.2785	9.6756	4.8127	13.3484	0.3501	9.1943	0.2915	0.0187	-0.1923	0.0044	-0.14	-0.1691	0.499	0.2964	-0.1515	0.5283	0.1193	0.0704	0.5764	-0.0876	0.1603	-8.263	-12.1703	-18.0978
70	3.5838	6.4061	-4.5867	24.9191	-8.4581	5.8877	-0.6071	-0.5832	-0.5385	1.005	0.0793	0.3083	0.6347	0.6651	0.5279	0.4732	0.2546	0.1208	0.666	0.2639	0.346	-17.5846	-14.3934	-15.8905
71	15.8843	-0.1166	-2.3439	4.2485	-2.7192	2.1192	0.0065	-0.0264	-0.778	0.3449	0.2666	0.482	-0.2084	-0.3082	-0.2731	0.4733	-0.0214	0.1965	0.973	0.221	0.1925	-30.5791	-9.4351	-13.1603
72	12.971	13.5791	10.1587	14.2419	10.6552	7.9748	-0.0289	-0.7291	1.0534	0.0448	-0.8131	1.1081	0.0579	-0.5711	0.842	0.3728	0.0967	0.1828	0.6948	-0.0287	0.3371	-28.2653	-1.0408	-14.1044
73	12.9319	-10.5076	-9.225	20.6913	16.1245	12.7909	-0.3948	0.1005	0.7289	0.6915	0.6846	-0.139	0.6324	0.339	-0.2898	0.3636	0.0959	-0.0479	0.493	0.165	0.2567	-18.9021	-6.2096	-23.8444
74	12.2392	-5.1846	-3.2868	2.2445	0.8482	8.4297	0.0257	0.268	-0.2731	0.0062	-0.0629	0.1287	0.7167	-0.478	0.0372	0.468	-0.0156	0.0705	0.3442	0.1542	0.2848	-22.8165	-14.7452	-24.5316
75	41.291	-20.484	-20.0365	10.4864	11.8417	20.8705	0.4354	-0.1398	-0.1351	-0.0968	-0.1163	0.0046	0.47	-1.0218	-0.3191	0.2172	-0.0472	0.1808	0.664	0.1217	0.6439	-37.8943	-6.7808	-21.85
76	7.6039	8.1065	-15.2669	47.7643	-24.0121	32.1906	0.1309	-0.9933	-0.2569	-0.8641	-0.5009	0.653	-0.0448	1.8186	0.37	0.1527	-0.0218	0.0138	0.9375	0.0384	0.4904	-42.8015	-0.4116	-24.4673
77	1.0025	-0.0886	-0.2042	2.4819	0.11	0.4811	-0.1397	-0.2664	0.0541	-0.238	0.4543	0.2003	-0.2212	-0.3247	-0.3146	0.331	0.1844	0.1045	0.5357	0.2371	0.4177	-24.7904	-5.6769	-32.0144
78	6.6505	-0.3612	8.6041	16.0229	5.7339	13.5351	0.4509	0.0984	-0.7324	0.0699	0.1047	1.0353	0.6105	0.1635	-0.5556	0.2074	-0.0066	0.009	0.4093	0.0778	0.4343	-22.6616	-22.3205	-33.7499
79	16.2935	3.8566	-1.1909	22.8805	17.4731	14.4396	-0.4307	0.2362	0.1113	0.0312	0.0452	0.5614	0.1312	-0.0136	0.3855	0.2244	0.0198	0.1058	0.4606	0.1168	0.5797	-29.8552	-16.5128	-33.3471
80	3.7436	-2.8737	7.165	2.2114	-5.5094	13.736	0.4811	-0.615	-0.3981	-0.3768	0.3909	0.33	0.9264	-1.0867	-0.872	0.4005	-0.1178	0.1312	1.2501	0.0099	0.6947	-33.9888	-9.3114	-33.6031
81	70.4608	-49.8406	-46.3557	56.9587	34.3532	30.6559	1.1357	-3.868	-1.7205	-6.2566	-1.966	0.1539	-1.0897	2.1075	0.8303	1.5556	0.8843	-0.0688	1.4519	0.6972	0.7203	31.7295	-41.847	-67.9658
82	0.5677	1.2457	-4.6189	2.9542	-11.7877	50.2139	-0.0608	-0.1499	-0.1443	0.1993	-0.2798	-0.1718	-2.0865	0.5467	0.3406	1.1047	0.214	0.1127	0.6483	-0.1486	0.3998	42.5302	-43.3602	-65.0016
83	3.7032	1.7212	6.3207	22.4562	16.4091	19.1698	-0.5866	0.6063	0.1188	-0.6288	0.3662	0.0715	-1.1912	1.0871	0.2204	0.6327	0.006	0.227	0.4255	0.2097	0.3539	39.705	-34.8261	-58.8924
84	15.4468	-12.0829	21.1076	29.8982	-25.8221	33.085	-0.5356	-0.3022	0.2514	1.4659	0.5294	0.563	-1.2418	-0.5545	0.0062	0.6292	0.0857	0.0317	0.3965	0.1155	0.2558	34.7307	-36.4756	-54.148
85	5.8781	1.3522	-2.5164	15.9503	6.135	3.9609	0.1679	0.5972	0.0506	0.053	-0.1178	-0.1896	-0.0387	-0.4056	-0.0501	0.3804	0.0469	-0.0123	0.4234	0.0257	0.1914	35.2483	-48.34	-57.0729
86	27.2798	-16.7517	-8.0887	10.3019	4.9514	2.4148	0.0325	0.8328	-1.194	0.0149	-0.3908	0.7554	-0.0411	-0.3565	0.3583	0.7125	0.0358	-0.167	0.8212	0.1312	0.6019	42.295	-58.8878	-60.3622
87	7.9543	-4.0973	-3.7123	2.1173	1.9118	1.7328	0.1481	-0.6007	1.1953	-0.0808	0.3951	-0.6048	-0.0504	0.275	-0.5432	0.7313	-0.1721	0.1653	0.8361	0.0182	0.2356	48.0277	-51.6471	-61.6684
88	6.3772	-3.7708	2.1071	21.2829	-1.5676	17.9283	-0.0483	0.1634	0.1969	-1.4568	-0.6835	-0.891	-0.4533	0.2562	0.7318	0.3139	0.0158	0.1311	0.2236	-0.0032	0.3145	47.1237	-45.211	-54.9261
89	9.3805	-2.6552	-5.7021	8.6943	-3.3397	8.8988	0.7267	-0.2081	-0.0655	-0.1008	-0.1411	-0.197	-1.2617	-0.084	-0.5856	0.426	0.0509	0.1112	0.2438	0.0895	0.3399	39.0537	-40.28	-46.4805
90	1.2598	-3.8139	-3.2574	12.2044	11.5038	13.315	0.0585	0.1708	-0.0761	-0.1164	-0.1197	0.06	-0.1462	0.0556	0.0612	0.3052	-0.0151	-0.0024	0.5276	-0.1179	0.3538	39.5918	-52.3628	-49.7099
91	2.9953	7.6676	-2.7433	20.2358	-7.0275	2.5126	-0.3748	0.2337	-0.0905	-1.4946	0.3012	-0.591	0.3384	-0.2128	0.0735	0.6112	0.2233	0.2927	0.361	0.0129	0.4138	48.604	-59.9915	-53.544
92	2.2575	0.3203	-2.4646	5.2714	0.622	2.8826	0.2715	-0.1098	0.0406	-0.242	-0.1905	-0.659	-0.3177	0.0609	-0.0809	0.1639	0.0351	0.0616	0.306	-0.0555	0.4401	47.456	-49.6308	-43.8803
93	10.4669	-10.5753	-4.3381	14.1877	2.0519	3.3656	0.0966	0.1287	-0.2941	-0.225	-0.1432	0.2596	-0.0155	-0.0638	0.0466	0.1885	-0.0296	-0.0061	0.2577	0.0096	0.4001	36.8362	-53.5065	-40.5731
94	14.8387	-12.1094	-1.1096	18.0446	10.9986	28.133	0.0184	-0.0546	-1.1064	0.798	-0.2584	0.5365	1.7782	-0.1204	0.2399	0.1523	-0.0129	-0.0754	0.2319	0.0167	0.3699	49.4865	-64.0168	-43.4732
95	17.3784	6.25	-1.1196	5.4604	2.4055	2.5279	0.7156	-1.2573	-1.4242	-0.5666	0.1042	-1.5802	-0.7535	0.5504	-0.8198	0.5927	0.1222	0.2087	0.8621	-0.3913	0.707	57.9896	-67.6435	-44.4369
96	2.2551	-1.4591	5.3638	2.2712	-3.3981	12.857	0.5464	0.6103	-0.0478	-0.2199	-0.182	-0.0878	1.1985	1.4658	-0.3644	0.3465	0.3004	0.1562	0.6382	-0.12	0.7071	57.071	-61.8896	-39.1462
97	1.1201	3.8572	0.9618	13.3689	3.3356	0.8329	-0.1453	0.0986	-0.2776	-0.2132	0.4819	-1.0163	-0.0565	0.1402	-0.3366	0.3297	0.0286	-0.0512	0.5709	-0.0859	0.4228	51.1035	-51.3393	-33.5481
98	22.8138	11.2508	-1.0418	11.7118	2.6741	7.3705	0.1028	-0.7522	0.3092	0.6251	-0.3228	0.1585	0.245	0.0202	0.2201	0.242	0.0292	-0.0171	0.1838	-0.0096	0.2269	38.4676	-53.4348	-28.8982
99	8.3388	0.4247	0.0058	1.0629	-1.7974	4.0872	0.2898	0.5196	-0.7435	-0.1611	0.0525	0.3566	0.9818	-0.2477	-0.3422	0.5317	-0.1015	0.092	0.2316	-0.0563	0.4999	35.9827	-60.6067	-32.4919
100	11.1769	-5.7454	-3.1449	13.2532	-13.8943	24.3087	-0.4375	-0.7138	-1.2137	0.1067	0.5466	0.8602	0.3327	0.0864	-0.1091	0.377	-0.0339	-0.0804	0.4278	0.011	0.5356	47.2904	-64.3311	-32.945
101	41.3132	22.0729	26.0496	53.6824	49.5645	46.7608	2.0042	-1.9019	1.6127	-0.0777	-2.9642	0.6751	0.245	-2.9235	0.96	0.8309	-0.0977	-0.0543	0.7648	0.2633	0.264	-19.1333	-44.8449	-45.9309
102	18.7996	4.0951	-24.1468	0.9516	-5.318	31.1146	-0.3332	1.2024	0.4023	-0.1916	0.5725	0.0311	0.7506	-1.5918	-0.2393	1.0621	-0.1361	-0.1686	1.5265	0.4487	0.9551	-24.089	-59.455	-48.066
103	26.9167	9.7854	17.4319	19.5907	-7.2355	22.801	-0.5295	0.2018	-1.2183	-1.8763	1.2223	-0.5462	1.0376	-0.7444	-0.6928	0.741	0.0164	-0.126	0.6827	-0.1391	0.1367	-16.0627	-61.6564	-43.7308
104	33.1988	-4.1572	-32.0825	29.3844	-19.0687	49.4742	-0.0938	1.3901	0.295	0.555	-0.8143	-1.7623	-0.5261	-0.9528	0.9082	0.4709	-0.0538	0.0273	0.6617	0.0262	0.4954	-10.3582	-56.2601	-39.5407
105	17.3562	7.4815	-11.813	50.1948	-14.4263	9.8965	0.6699	2.0974	-0.1032	0.1875	-0.5762	0.7275	-0.4564	-1.1505	-0.0937	0.628	0.0434	-0.0904	0.6684	0.1095	0.0791	-18.8645	-52.0863	-37.2284
106	0.341	2.4243	1.1964	18.5868	9.2201	4.576	0.0576	0.0931	0.0169	-0.4364	-0.0666	0.0522	-0.2331	-0.0727	0.009	0.6666	0.2011	-0.2495	0.8951	0.3786	0.5346	-31.0076	-55.6967	-37.3166
107	6.5645	-2.8068	2.4826	14.2266	13.7979	17.8955	0.1391	-0.2319	0.4315	-0.7475	-0.4025	-0.0899	-0.6777	-0.6861	0.2634	0.5463	-0.0082	-0.0742	0.7315	0.0259	0.2589	-32.0591	-63.2477	-40.7718
108	10.4436	-11.4963	-6.9717	15.6221	6.1283	5.4893	-0.4419	0.5653	0.177	0.991	0.1349	-0.4305	0.5364	-0.5676	0.307	0.8031	0.1633	0.049	0.578	-0.0911	0.1924	-20.8641	-65.3995	-35.06
109	22.7983	-14.0543	-0.2472	11.6957	-0.7685	0.2832	1.1345	0.6143	-0.3834	-1.0162	-1.0099	0.5426	0.0592	0.1805	-0.1246	0.522	-0.0659	-0.1038	0.5163	0.0083	0.1172	-14.0574	-57.6468	-29.1064
110	7.2097	1.2485	-4.8404	0.6012	-2.0509	7.1389	-0.2297	1.1365	0.1072	0.1163	-0.0155	-0.0321	-0.4522	-0.0759	0.2452	0.3586	0.0317	-0.1899	0.5062	0.0486	0.3576	-30.9587	-60.1916	-30.1608
111	21.6199	-9.6149	4.4867	8.243	1.85	4.6836	0.1665	0.3631	-0.2916	0.2361	-0.1209	0.1282	0.3527	0.0006	-0.0456	0.3075	0.0055	-0.0327	0.4285	0.0926	0.3601	-30.3184	-69.3839	-30.4868
112	11.0865	1.9125	7.558	0.3874	1.0503	6.3312	0.0011	-0.0425	-0.1499	0.0148	-0.0608	-0.0417	-0.1865	0.2748	0.0596	0.3926	0.0421	-0.0434	0.3734	0.0675	0.2953	-21.0791	-64.756	-21.9204
113	13.8663	7.4568	1.6479	6.7106	-1.3366	2.0442	-0.7091	0.1487	0.3569	-0.0534	0.3667	-0.024	-0.3911	-0.1514	0.3423	0.3441	0.0899	-0.0843	0.409	0.0502	0.3102	-22.2523	-54.6073	-19.575
114	12.5922	-8.2952	14.5849	5.4711	-9.6151	16.9018	-0.2326	-0.5768	-0.5162	0.342	0.6003	0.3487	-0.5776	-0.6827	-0.3676	0.3437	-0.0364	-0.0575	0.9149	-0.1499	0.4457	-36.3411	-64.5094	-20.7119
115	2.6891	-0.4941	10.4779	0.1137	-1.9465	40.8782	1.0039	0.2654	-0.2841	-0.1724	0.129	0.0767	3.6449	0.9695	-1.1329	0.6417	-0.0569	-0.0193	0.9476	-0.0604	0.9948	-43.5012	-74.1888	-20.8027
116	0.1575	0.4066	0.6191	7.9643	4.0827	3.3331	0.149	-0.2895	0.1026	0.0609	-0.3602	-0.1668	0.4499	-1.0411	0.2112	0.3979	-0.1657	0.0456	0.799	-0.0249	0.375	-33.4665	-73.2796	-16.7851
117	7.0514	-2.786	4.1445	5.5926	1.7085	4.944	0.5224	-0.2666	-0.1454	0.0763	-0.4003	-0.0895	0.4088	-0.6154	-0.1221	0.3262	0.0568	-0.0584	0.4627	0.1451	0.2578	-22.702	-64.6369	-11.3894
118	11.8104	-9.6	-0.4943	8.0013	-1.0329	14.6908	0.5442	-0.8121	0.5428	-0.4216	0.5675	-0.2083	-0.7229	0.09	-1.1117	0.2774	-0.0115	-0.0197	0.5213	0.0086	0.5049	-25.2346	-49.9768	-10.3718
119	9.8749	7.913	4.9038	26.0674	20.5333	16.4113	-0.1961	-0.3411	0.6995	-0.3265	-0.578	1.1056	-0.2508	-0.4235	0.7741	0.2137	0.222	-0.1117	0.7255	0.1054	0.3853	-32.1417	-56.556	-10.5781
120	35.2436	4.1331	-14.4534	0.5533	-1.6956	5.9365	1.1256	0.2044	1.8404	0.259	-0.2594	0.1467	-0.4722	-0.062	-0.8662	0.5563	-0.1943	-0.1665	0.9743	0.0877	0.6086	-34.7295	-64.1042	-10.2061

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	16 - 25
2	X-RAY DIFFRACTION	2	A	26 - 40
3	X-RAY DIFFRACTION	3	A	41 - 63
4	X-RAY DIFFRACTION	4	A	64 - 70
5	X-RAY DIFFRACTION	5	A	71 - 80
6	X-RAY DIFFRACTION	6	A	81 - 104
7	X-RAY DIFFRACTION	7	A	105 - 110
8	X-RAY DIFFRACTION	8	A	111 - 115
9	X-RAY DIFFRACTION	9	A	116 - 135
10	X-RAY DIFFRACTION	10	A	136 - 143
11	X-RAY DIFFRACTION	11	A	144 - 155
12	X-RAY DIFFRACTION	12	A	156 - 167
13	X-RAY DIFFRACTION	13	A	168 - 176
14	X-RAY DIFFRACTION	14	A	177 - 186
15	X-RAY DIFFRACTION	15	A	187 - 197
16	X-RAY DIFFRACTION	16	A	198 - 204
17	X-RAY DIFFRACTION	17	A	205 - 212
18	X-RAY DIFFRACTION	18	A	213 - 220
19	X-RAY DIFFRACTION	19	A	221 - 226
20	X-RAY DIFFRACTION	20	A	227 - 231
21	X-RAY DIFFRACTION	21	B	16 - 22
22	X-RAY DIFFRACTION	22	B	23 - 42
23	X-RAY DIFFRACTION	23	B	43 - 51
24	X-RAY DIFFRACTION	24	B	52 - 60
25	X-RAY DIFFRACTION	25	B	61 - 70
26	X-RAY DIFFRACTION	26	B	71 - 75
27	X-RAY DIFFRACTION	27	B	76 - 96
28	X-RAY DIFFRACTION	28	B	97 - 107
29	X-RAY DIFFRACTION	29	B	108 - 115
30	X-RAY DIFFRACTION	30	B	116 - 135
31	X-RAY DIFFRACTION	31	B	136 - 141
32	X-RAY DIFFRACTION	32	B	142 - 147
33	X-RAY DIFFRACTION	33	B	148 - 161
34	X-RAY DIFFRACTION	34	B	162 - 168
35	X-RAY DIFFRACTION	35	B	169 - 174
36	X-RAY DIFFRACTION	36	B	175 - 193
37	X-RAY DIFFRACTION	37	B	194 - 201
38	X-RAY DIFFRACTION	38	B	202 - 217
39	X-RAY DIFFRACTION	39	B	218 - 225
40	X-RAY DIFFRACTION	40	B	226 - 230
41	X-RAY DIFFRACTION	41	C	16 - 26
42	X-RAY DIFFRACTION	42	C	27 - 42
43	X-RAY DIFFRACTION	43	C	43 - 55
44	X-RAY DIFFRACTION	44	C	56 - 62
45	X-RAY DIFFRACTION	45	C	63 - 73
46	X-RAY DIFFRACTION	46	C	74 - 78
47	X-RAY DIFFRACTION	47	C	79 - 102
48	X-RAY DIFFRACTION	48	C	103 - 109
49	X-RAY DIFFRACTION	49	C	110 - 126
50	X-RAY DIFFRACTION	50	C	127 - 136
51	X-RAY DIFFRACTION	51	C	137 - 146
52	X-RAY DIFFRACTION	52	C	147 - 155
53	X-RAY DIFFRACTION	53	C	156 - 168
54	X-RAY DIFFRACTION	54	C	169 - 173
55	X-RAY DIFFRACTION	55	C	174 - 199
56	X-RAY DIFFRACTION	56	C	200 - 204
57	X-RAY DIFFRACTION	57	C	205 - 210
58	X-RAY DIFFRACTION	58	C	211 - 220
59	X-RAY DIFFRACTION	59	C	221 - 225
60	X-RAY DIFFRACTION	60	C	226 - 231
61	X-RAY DIFFRACTION	61	D	335 - 342
62	X-RAY DIFFRACTION	62	D	343 - 348
63	X-RAY DIFFRACTION	63	D	349 - 356
64	X-RAY DIFFRACTION	64	D	357 - 363
65	X-RAY DIFFRACTION	65	D	364 - 371
66	X-RAY DIFFRACTION	66	D	372 - 377
67	X-RAY DIFFRACTION	67	D	378 - 384
68	X-RAY DIFFRACTION	68	D	385 - 392
69	X-RAY DIFFRACTION	69	D	393 - 398
70	X-RAY DIFFRACTION	70	D	399 - 405
71	X-RAY DIFFRACTION	71	D	406 - 417
72	X-RAY DIFFRACTION	72	D	418 - 422
73	X-RAY DIFFRACTION	73	D	423 - 435
74	X-RAY DIFFRACTION	74	D	436 - 452
75	X-RAY DIFFRACTION	75	D	453 - 458
76	X-RAY DIFFRACTION	76	D	459 - 466
77	X-RAY DIFFRACTION	77	D	467 - 488
78	X-RAY DIFFRACTION	78	D	489 - 494
79	X-RAY DIFFRACTION	79	D	495 - 500
80	X-RAY DIFFRACTION	80	D	501 - 506
81	X-RAY DIFFRACTION	81	E	334 - 339
82	X-RAY DIFFRACTION	82	E	340 - 345
83	X-RAY DIFFRACTION	83	E	346 - 352
84	X-RAY DIFFRACTION	84	E	353 - 357
85	X-RAY DIFFRACTION	85	E	358 - 368
86	X-RAY DIFFRACTION	86	E	369 - 374
87	X-RAY DIFFRACTION	87	E	375 - 380
88	X-RAY DIFFRACTION	88	E	381 - 387
89	X-RAY DIFFRACTION	89	E	388 - 400
90	X-RAY DIFFRACTION	90	E	401 - 409
91	X-RAY DIFFRACTION	91	E	410 - 417
92	X-RAY DIFFRACTION	92	E	418 - 435
93	X-RAY DIFFRACTION	93	E	436 - 450
94	X-RAY DIFFRACTION	94	E	451 - 457
95	X-RAY DIFFRACTION	95	E	458 - 462
96	X-RAY DIFFRACTION	96	E	463 - 471
97	X-RAY DIFFRACTION	97	E	472 - 480
98	X-RAY DIFFRACTION	98	E	481 - 489
99	X-RAY DIFFRACTION	99	E	490 - 501
100	X-RAY DIFFRACTION	100	E	502 - 506
101	X-RAY DIFFRACTION	101	F	332 - 338
102	X-RAY DIFFRACTION	102	F	339 - 344
103	X-RAY DIFFRACTION	103	F	345 - 350
104	X-RAY DIFFRACTION	104	F	351 - 356
105	X-RAY DIFFRACTION	105	F	357 - 361
106	X-RAY DIFFRACTION	106	F	362 - 371
107	X-RAY DIFFRACTION	107	F	372 - 380
108	X-RAY DIFFRACTION	108	F	381 - 390
109	X-RAY DIFFRACTION	109	F	391 - 400
110	X-RAY DIFFRACTION	110	F	401 - 415
111	X-RAY DIFFRACTION	111	F	416 - 425
112	X-RAY DIFFRACTION	112	F	426 - 432
113	X-RAY DIFFRACTION	113	F	433 - 447
114	X-RAY DIFFRACTION	114	F	448 - 457
115	X-RAY DIFFRACTION	115	F	458 - 462
116	X-RAY DIFFRACTION	116	F	463 - 474
117	X-RAY DIFFRACTION	117	F	475 - 486
118	X-RAY DIFFRACTION	118	F	487 - 494
119	X-RAY DIFFRACTION	119	F	495 - 500
120	X-RAY DIFFRACTION	120	F	501 - 506

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Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)

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Yorodumi